Ku-Lung Hsu

Primary Appointment

  • Assistant Professor, Chemistry

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Research Interest(s)

Lipid Metabolism in Inflammation and Immunity

Research Description

Professor Hsu’s research program aims to integrate chemical biology and mass spectrometry-based technologies to address fundamental challenges associated with studying regulation of metabolism in vivo. His goal is to develop new chemical and bioanalytical methods to understand pathways of metabolic regulation and translate these findings into new therapeutic strategies for inflammatory and metabolic disease. To achieve his goals, Professor Hsu’s group synthesizes and applies small molecule probes and inhibitors to detect and inactivate metabolic enzymes and pathways in complex biological systems in vivo.

Selected Publications

  • Franks C, Campbell S, Purow B, Harris T, Hsu K. The Ligand Binding Landscape of Diacylglycerol Kinases. Cell chemical biology. 2017;24(7): 870-880.e5. PMID: 28712745 | PMCID: PMC5551460
  • Shin M, Snyder H, Donvito G, Schurman L, Fox T, Lichtman A, Kester M, Hsu K. Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo. Molecular pharmaceutics. 2017. PMID: 28901776
  • Chang J, Zuhl A, Speers A, Niessen S, Brown S, Mulvihill M, Fan Y, Spicer T, Southern M, Scampavia L, Fernandez-Vega V, Dix M, Cameron M, Hodder P, Rosen H, Nomura D, Kwon O, Hsu K, Cravatt B. Selective Inhibitor of Platelet-Activating Factor Acetylhydrolases 1b2 and 1b3 That Impairs Cancer Cell Survival. ACS chemical biology. 2015. PMID: 25602368