Kevin R. Lynch


  • MS, University of Rhode Island, Kingston, RI
  • BS, Pennsylvania State University, University Park, PA
  • PhD, University of Rhode Island, Kingston, RI
  • Postdoc, Columbia University, New York, NY

Primary Appointment

  • Professor, Pharmacology


Research Interest(s) order viagra online canada mastercard

Research Description

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Selected Publications

  • Bajwa A, Rosin D, Chroscicki P, Lee S, Dondeti K, Ye H, Kinsey G, Stevens B, Jobin K, Kenwood B, Hoehn K, Lynch K, Okusa M. Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury. Journal of the American Society of Nephrology : JASN. 2014. PMID: 25145931
  • Kenwood B, Weaver J, Bajwa A, Poon I, Byrne F, Murrow B, Calderone J, Huang L, Divakaruni A, Tomsig J, Okabe K, Lo R, Cameron Coleman G, Columbus L, Yan Z, Saucerman J, Smith J, Holmes J, Lynch K, Ravichandran K, Uchiyama S, Santos W, Rogers G, Okusa M, Bayliss D, Hoehn K. Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Molecular metabolism. 2014;3(2): 114-23. PMID: 24634817 | PMCID: PMC3953706
  • Building a better sphingosine kinase-1 inhibitor. The Biochemical journal. 2012;444(1): e1-2. PMID: 22533672
  • Bajwa A, Huang L, Ye H, Dondeti K, Song S, Rosin D, Lynch K, Lobo P, Li L, Okusa M. Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury. Journal of immunology (Baltimore, Md. : 1950). 2012;189(5): 2584-96. PMID: 22855711 | PMCID: PMC3433235
  • Gellett A, Kharel Y, Sunkara M, Morris A, Lynch K. Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases. Biochemical and biophysical research communications. 2012;422(4): 758-63. PMID: 22627129 | PMCID: PMC3377814
  • Kharel Y, Raje M, Gao M, Gellett A, Tomsig J, Lynch K, Santos W. Sphingosine kinase type¬†2 inhibition elevates circulating sphingosine 1-phosphate. The Biochemical journal. 2012;447(1): 149-57. PMID: 22747486 | PMCID: PMC3443596
  • Knott K, Kharel Y, Raje M, Lynch K, Santos W. Effect of alkyl chain length on sphingosine kinase 2 selectivity. Bioorganic & medicinal chemistry letters. 2012;22(22): 6817-20. PMID: 22321213 | PMCID: PMC3394931
  • Awad A, Rouse M, Khutsishvili K, Huang L, Bolton W, Lynch K, Okusa M. Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes. Kidney international. 2011;79(10): 1090-8. PMID: 21289599 | PMCID: PMC3155206
  • East J, Carter K, Kennedy P, Schulte N, Toews M, Lynch K, Macdonald T. Development of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist. MedChemComm. 2011;2(4): 325-330. PMID: 22180836 | PMCID: PMC3237054
  • Kennedy A, Mathews T, Kharel Y, Field S, Moyer M, East J, Houck J, Lynch K, Macdonald T. Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. Journal of medicinal chemistry. 2011;54(10): 3524-48. PMID: 21495716 | PMCID: PMC3119570
  • Kennedy P, Zhu R, Huang T, Tomsig J, Mathews T, David M, Peyruchaud O, Macdonald T, Lynch K. Characterization of a sphingosine 1-phosphate receptor antagonist prodrug. The Journal of pharmacology and experimental therapeutics. 2011;338(3): 879-89. PMID: 21632869 | PMCID: PMC3164350
  • Kharel Y, Mathews T, Gellett A, Tomsig J, Kennedy P, Moyer M, Macdonald T, Lynch K. Sphingosine kinase type¬†1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate. The Biochemical journal. 2011;440(3): 345-53. PMID: 21848514 | PMCID: PMC3443603
  • Kharel Y, Mathews T, Kennedy A, Houck J, Macdonald T, Lynch K. A rapid assay for assessment of sphingosine kinase inhibitors and substrates. Analytical biochemistry. 2011;411(2): 230-5. PMID: 21216217 | PMCID: PMC3049835
  • Raje M, Knott K, Kharel Y, Bissel P, Lynch K, Santos W. Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors. Bioorganic & medicinal chemistry. 2011;20(1): 183-94. PMID: 22137932 | PMCID: NIHMS338841
  • Bajwa A, Jo S, Ye H, Huang L, Dondeti K, Rosin D, Haase V, Macdonald T, Lynch K, Okusa M. Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury. Journal of the American Society of Nephrology : JASN. 2010;21(6): 955-65. PMID: 20338995 | PMCID: PMC2900956
  • East J, Kennedy A, Tomsig J, De Leon A, Lynch K, Macdonald T. Synthesis and structure-activity relationships of tyrosine-based inhibitors of autotaxin (ATX). Bioorganic & medicinal chemistry letters. 2010;20(23): 7132-6. PMID: 20951039 | PMCID: PMC2975792
  • Mathews T, Kennedy A, Kharel Y, Kennedy P, Nicoara O, Sunkara M, Morris A, Wamhoff B, Lynch K, Macdonald T. Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors. Journal of medicinal chemistry. 2010;53(7): 2766-78. PMID: 20205392 | PMCID: PMC2875079
  • Foss F, Mathews T, Kharel Y, Kennedy P, Snyder A, Davis M, Lynch K, Macdonald T. Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs. Bioorganic & medicinal chemistry. 2009;17(16): 6123-36. PMID: 19632123 | PMCID: PMC2793099
  • Okusa M, Lynch K. Targeting sphingosine 1 phosphate receptor type 1 receptors in acute kidney injury. Drug discovery today. Disease mechanisms. 2009;4(1): 55-59. PMID: 19448841 | PMCID: PMC2682423
  • Petrie Aronin C, Sefcik L, Tholpady S, Tholpady A, Sadik K, Macdonald T, Peirce S, Wamhoff B, Lynch K, Ogle R, Botchwey E. FTY720 promotes local microvascular network formation and regeneration of cranial bone defects. Tissue engineering. Part A. 2009;16(6): 1801-9. PMID: 20038198 | PMCID: PMC2949231
  • Tomsig J, Snyder A, Berdyshev E, Skobeleva A, Mataya C, Natarajan V, Brindley D, Lynch K. Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acid in vivo. The Biochemical journal. 2009;419(3): 611-8. PMID: 19215222 | PMCID: PMC2677185
  • Hughes J, Srinivasan S, Lynch K, Proia R, Ferdek P, Hedrick C. Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages. Circulation research. 2008;102(8): 950-8. PMID: 18323526 | PMCID: PMC2875063
  • Jo S, Bajwa A, Awad A, Lynch K, Okusa M. Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease. Kidney international. 2008;73(11): 1220-30. PMID: 18322542 | PMCID: PMC2614447
  • Jo S, Bajwa A, Ye H, Vergis A, Awad A, Kharel Y, Lynch K, Okusa M. Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury. Kidney international. 2008;75(2): 167-75. PMID: 18971925 | PMCID: PMC2646633
  • Lynch K, Macdonald T. Sphingosine 1-phosphate chemical biology. Biochimica et biophysica acta. 2008;1781(9): 508-12. PMID: 18638568 | PMCID: PMC3412363
  • Rivera-Lopez C, Tucker A, Lynch K. Lysophosphatidic acid (LPA) and angiogenesis. Angiogenesis. 2008;11(3): 301-10. PMID: 18504643 | PMCID: PMC2677190
  • Wamhoff B, Lynch K, Macdonald T, Owens G. Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype. Arteriosclerosis, thrombosis, and vascular biology. 2008;28(8): 1454-61. PMID: 18535287 | PMCID: PMC2605659
  • Cui P, McCalmont W, Tomsig J, Lynch K, Macdonald T. alpha- and beta-substituted phosphonate analogs of LPA as autotaxin inhibitors. Bioorganic & medicinal chemistry. 2007;16(5): 2212-25. PMID: 18082408 | PMCID: PMC2907913
  • Cui P, Tomsig J, McCalmont W, Lee S, Becker C, Lynch K, Macdonald T. Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors. Bioorganic & medicinal chemistry letters. 2007;17(6): 1634-40. PMID: 17257836 | PMCID: NIHMS20052
  • Srinivasan S, Bolick D, Lukashev D, Lappas C, Sitkovsky M, Lynch K, Hedrick C. Sphingosine-1-phosphate reduces CD4+ T-cell activation in type 1 diabetes through regulation of hypoxia-inducible factor short isoform I.1 and CD69. Diabetes. 2007;57(2): 484-93. PMID: 18003758
  • Zhu R, Snyder A, Kharel Y, Schaffter L, Sun Q, Kennedy P, Lynch K, Macdonald T. Asymmetric synthesis of conformationally constrained fingolimod analogues--discovery of an orally active sphingosine 1-phosphate receptor type-1 agonist and receptor type-3 antagonist. Journal of medicinal chemistry. 2007;50(25): 6428-35. PMID: 17994678 | PMCID: PMC2895489
  • Awad A, Ye H, Huang L, Li L, Foss F, Macdonald T, Lynch K, Okusa M. Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney. American journal of physiology. Renal physiology. 2006;290(6): F1516-24. PMID: 16403835
  • Foss F, Snyder A, Davis M, Rouse M, Okusa M, Lynch K, Macdonald T. Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorganic & medicinal chemistry. 2006;15(2): 663-77. PMID: 17113298 | PMCID: PMC1963459