K. Kevin Pfister

Education

  • BA, University of Virginia
  • PhD, Princeton University
  • Postdoc, University of California, Berkeley
  • Postdoc, University of Texas Southwestern Medical Center

Primary Appointment

  • Associate Professor, Cell Biology

Contact

Research Interest(s)

Structure, Function, and Regulation of Cytoplasmic Dynein: Its Role in Intracellular Microtubule-based Transport, Membrane Bounded Organelle Trafficking, Axonal Transport and Mitosis

Research Description

Selected Publications

  • Blasier K, Humsi M, Ha J, Ross M, Smiley W, Inamdar N, Mitchell D, Lo K, Pfister K. Live cell imaging reveals differential modifications to cytoplasmic dynein properties by phospho- and dephosphomimic mutations of the intermediate chain 2C S84. Journal of neuroscience research. 2014;92(9): 1143-54. PMID: 24798412 | PMCID: PMC4107179
  • Mitchell D, Blasier K, Jeffery E, Ross M, Pullikuth A, Suo D, Park J, Smiley W, Lo K, Shabanowitz J, Deppmann C, Trinidad J, Hunt D, Catling A, Pfister K. Trk activation of the ERK1/2 kinase pathway stimulates intermediate chain phosphorylation and recruits cytoplasmic dynein to signaling endosomes for retrograde axonal transport. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012;32(44): 15495-510. PMID: 23115187 | PMCID: PMC3500848
  • Ha J, Lo K, Myers K, Carr T, Humsi M, Rasoul B, Segal R, Pfister K. A neuron-specific cytoplasmic dynein isoform preferentially transports TrkB signaling endosomes. The Journal of cell biology. 2008;181(6): 1027-39. PMID: 18559670 | PMCID: PMC2426944
  • Lo K, Kogoy J, Pfister K. The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3. The Journal of biological chemistry. 2007;282(15): 11205-12. PMID: 17289665
  • Lo K, Kan H, Pfister K. Identification of a novel region of the cytoplasmic Dynein intermediate chain important for dimerization in the absence of the light chains. The Journal of biological chemistry. 2006;281(14): 9552-9. PMID: 16452477