Judith A. Woodfolk

Education

  • MD, Sheffield University
  • PhD, University of Virginia
  • MBChB, Sheffield University

Contact

Research Interest(s)

Cellular mechanisms of allergic disease in humans.

Research Description

My research is driven by theories which challenge current concepts, and by novel ideas, related to the role of T cells, dendritic cells and basophils in allergic disease. The primary objective of my work is to gain new insight into cellular mechanisms that initiate and promote allergic responses in humans. My foray into cellular immunology began during my thesis work which focused on defining major T cell epitopes of allergens in humans.

Current projects include: (1) analysis of the role of effector and regulatory T cells in severe allergic disease; (2) cellular and molecular studies on the role of TSLP and its receptor in allergic disease; (3) investigation of the role of extracellular matrix molecules in atopic dermatitis; and (4) immune mechanisms of rhinovirus-induced asthma exacerbations. Our work involves a high degree of collaboration with clinical specialists in adult and pediatric allergy and pediatric respiratory medicine, as well as with basic scientists in the fields of murine immunology, virology, biochemistry, genetics, epigenetics, and molecular biology. By focusing on human-based systems, we aim to accelerate the transition of experimental findings from the bench to the bedside.

Selected Publications

  • Allakhverdi Z, Comeau M, Armant M, Agrawal R, Woodfolk J, Sehmi R, Howie K, Gauvreau G, Delespesse G. Mast Cell-Activated Bone Marrow Mesenchymal Stromal Cells Regulate Proliferation and Lineage Commitment of CD34(+) Progenitor Cells. Frontiers in immunology. 2014;4 461. PMID: 24381572 | PMCID: PMC3865761
  • Romeo M, Agrawal R, Pomés A, Woodfolk J. A molecular perspective on TH2-promoting cytokine receptors in patients with allergic disease. The Journal of allergy and clinical immunology. 2013;133(4): 952-60. PMID: 24084078 | PMCID: PMC3969406
  • Commins S, Kelly L, Rönmark E, James H, Pochan S, Peters E, Lundbäck B, Nganga L, Cooper P, Hoskins J, Eapen S, Matos L, McBride D, Heymann P, Woodfolk J, Perzanowski M, Platts-Mills T. Galactose-α-1,3-galactose-specific IgE is associated with anaphylaxis but not asthma. American journal of respiratory and critical care medicine. 2012;185(7): 723-30. PMID: 22281828 | PMCID: PMC3326422
  • Agrawal R, Wisniewski J, Woodfolk J. The role of regulatory T cells in atopic dermatitis. Current problems in dermatology. 2011;41 112-24. PMID: 21576952
  • Erwin E, Woodfolk J, Ronmark E, Perzanowski M, Platts-Mills T. The long-term protective effects of domestic animals in the home. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2011;41(7): 920-2. PMID: 21668815
  • Platts-Mills T, Woodfolk J. Allergens and their role in the allergic immune response. Immunological reviews. 2011;242(1): 51-68. PMID: 21682738
  • Hulse K, Reefer A, Engelhard V, Patrie J, Ziegler S, Chapman M, Woodfolk J. Targeting allergen to FcgammaRI reveals a novel T(H)2 regulatory pathway linked to thymic stromal lymphopoietin receptor. The Journal of allergy and clinical immunology. 2010;125(1): 247-56.e1-8. PMID: 20109752 | PMCID: PMC2814452
  • Reefer A, Hulse K, Lannigan J, Solga M, Wright P, Kelly L, Patrie J, Chapman M, Woodfolk J. Flow cytometry imaging identifies rare T(H)2 cells expressing thymic stromal lymphopoietin receptor in a "proallergic" milieu. The Journal of allergy and clinical immunology. 2010;126(5): 1049-58, 1058.e1-10. PMID: 20888036 | PMCID: PMC3034251
  • Platts-Mills T, Erwin E, Heymann P, Woodfolk J. Pro: The evidence for a causal role of dust mites in asthma. American journal of respiratory and critical care medicine. 2009;180(2): 109-13; discussion 120-1. PMID: 19395504
  • Platts-Mills T, Woodfolk J. Trichophyton asthma. Chest. 2009;135(4): 887-8. PMID: 19349392