Judith A. Woodfolk

Education

  • MBChB, Sheffield University
  • PhD, University of Virginia

Primary Appointment

  • Professor, Medicine- Asthma, Allergy and Immunology

Contact

Research Interest(s)

Cellular and molecular mechanisms of allergic disease in humans.

Research Description

Research in my lab focuses on improving our understanding of how the human immune system responds to environmental triggers of allergic disease. The prevalence of allergic diseases, including asthma, has risen dramatically in the last few decades. Exposure to rhinovirus, the major cause of common cold, is an important risk factor for acute asthma episodes. The primary objective of my work is to gain new insight into cellular mechanisms that promote pathogenic and protective responses to allergens and rhinovirus in humans.

Current projects include: (1) Mechanisms of cross-protective adaptive immunity to human rhinovirus in an experimental human infection model; (2) Mechanisms of T-cell dysregulation in rhinovirus-induced asthma; and (3) The role of the TSLP pathway in allergic inflammation.

Ongoing work uses novel tools and state-of-the-art technologies to provide a systems biology perspective of immune activation in humans. Our approach involves a high degree of collaboration with clinical specialists in adult and pediatric allergy/respiratory medicine, as well as with basic scientists in the fields of virology, biochemistry, genetics, transcriptomics, and single-cell analytics.

Selected Publications

  • Heymann P, Nguyen H, Steinke J, Turner R, Woodfolk J, Platts-Mills T, Martin L, He H, Biagini Myers J, Lindsey M, Sivaprasad U, Medvedovic M, Mahi N, Carper H, Murphy D, Patrie J, Khurana Hershey G. Rhinovirus infection results in stronger and more persistent genomic dysregulation: Evidence for altered innate immune response in asthmatics at baseline, early in infection, and during convalescence. PloS one. 2017;12(5): e0178096. PMID: 28552993 | PMCID: PMC5446117
  • Muehling L, Lawrence M, Woodfolk J. Pathogenic CD4(+) T cells in patients with asthma. The Journal of allergy and clinical immunology. 2017. PMID: 28442213
  • Platts-Mills T, Woodfolk J. Mite Avoidance as a Logical Treatment for Severe Asthma in Childhood. Why Not? American journal of respiratory and critical care medicine. 2017;196(2): 119-121. PMID: 28707970
  • Turner R, Woodfolk J, Borish L, Steinke J, Patrie J, Muehling L, Lahtinen S, Lehtinen M. Effect of probiotic on innate inflammatory response and viral shedding in experimental rhinovirus infection - a randomised controlled trial. Beneficial microbes. 2017;8(2): 207-215. PMID: 28343401
  • Wisniewski J, Muehling L, Eccles J, Capaldo B, Agrawal R, Shirley D, Patrie J, Workman L, Schuyler A, Lawrence M, Teague W, Woodfolk J. TH1 signatures are present in the lower airways of children with severe asthma, regardless of allergic status. The Journal of allergy and clinical immunology. 2017. PMID: 28939412
  • Benign TH2 immunity in children: A fresh perspective on control of the allergic response. The Journal of allergy and clinical immunology. 2016;137(2): 388-9. PMID: 26853130
  • Lawrence M, Woodfolk J, Schuyler A, Stillman L, Chapman M, Platts-Mills T. Half-life of IgE in serum and skin: Consequences for anti-IgE therapy in patients with allergic disease. The Journal of allergy and clinical immunology. 2016;139(2): 422-428.e4. PMID: 27496596 | PMCID: PMC5405770
  • Muehling L, Mai D, Kwok W, Heymann P, Pomés A, Woodfolk J. Circulating Memory CD4+ T Cells Target Conserved Epitopes of Rhinovirus Capsid Proteins and Respond Rapidly to Experimental Infection in Humans. Journal of immunology (Baltimore, Md. : 1950). 2016;197(8): 3214-3224. PMID: 27591323 | PMCID: PMC5101128
  • Platts-Mills T, Heymann P, Commins S, Woodfolk J. The discovery of IgE 50 years later. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2016;116(3): 179-82. PMID: 26945493
  • Platts-Mills T, Schuyler A, Erwin E, Commins S, Woodfolk J. IgE in the diagnosis and treatment of allergic disease. The Journal of allergy and clinical immunology. 2016;137(6): 1662-1670. PMID: 27264001 | PMCID: PMC5406226
  • Roberts G, Boyle R, Bryce P, Crane J, Hogan S, Saglani S, Wickman M, Woodfolk J. Developments in the field of allergy mechanisms in 2015 through the eyes of Clinical & Experimental Allergy. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2016;46(10): 1248-57. PMID: 27682977
  • Roberts G, Boyle R, Bryce P, Crane J, Hogan S, Saglani S, Wickman M, Woodfolk J. Developments in the field of clinical allergy in 2015 through the eyes of Clinical and Experimental Allergy. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2016;46(11): 1389-1397. PMID: 27748974
  • Wisniewski J, Commins S, Agrawal R, Hulse K, Yu M, Cronin J, Heymann P, Pomes A, Platts-Mills T, Workman L, Woodfolk J. Analysis of cytokine production by peanut-reactive T cells identifies residual Th2 effectors in highly allergic children who received peanut oral immunotherapy. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2015;45(7): 1201-13. PMID: 25823600 | PMCID: PMC4472497
  • Woodfolk J, Commins S, Schuyler A, Erwin E, Platts-Mills T. Allergens, sources, particles, and molecules: Why do we make IgE responses? Allergology international : official journal of the Japanese Society of Allergology. 2015;64(4): 295-303. PMID: 26433525
  • Woodfolk J, Glesner J, Wright P, Kepley C, Li M, Himly M, Muehling L, Gustchina A, Wlodawer A, Chapman M, Pomés A. Antigenic Determinants of the Bilobal Cockroach Allergen Bla g 2. The Journal of biological chemistry. 2015;291(5): 2288-301. PMID: 26644466 | PMCID: PMC4732212
  • Agrawal R, Hulse K, Woodfolk J. Targeting antibody receptors as an approach towards immunotherapy. Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut fur Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen. 2014;97 153-6. PMID: 24912330
  • Agrawal R, Wisniewski J, Yu M, Kennedy J, Platts-Mills T, Heymann P, Woodfolk J. Infection with human rhinovirus 16 promotes enhanced IgE responsiveness in basophils of atopic asthmatics. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2014;44(10): 1266-73. PMID: 25113532 | PMCID: PMC4191843
  • Agrawal R, Woodfolk J. Skin barrier defects in atopic dermatitis. Current allergy and asthma reports. 2014;14(5): 433. PMID: 24633617 | PMCID: PMC4034059
  • Allakhverdi Z, Comeau M, Armant M, Agrawal R, Woodfolk J, Sehmi R, Howie K, Gauvreau G, Delespesse G. Mast Cell-Activated Bone Marrow Mesenchymal Stromal Cells Regulate Proliferation and Lineage Commitment of CD34(+) Progenitor Cells. Frontiers in immunology. 2014;4 461. PMID: 24381572 | PMCID: PMC3865761
  • Erwin E, Woodfolk J, James H, Satinover S, Platts-Mills T. Changes in cat specific IgE and IgG antibodies with decreased cat exposure. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2014;112(6): 545-550.e1. PMID: 24726651
  • Romeo M, Agrawal R, Pomés A, Woodfolk J. Reply: To PMID 24084078. The Journal of allergy and clinical immunology. 2014;134(3): 762-3. PMID: 25042745 | PMCID: PMC4547453
  • Romeo M, Agrawal R, Pomés A, Woodfolk J. A molecular perspective on TH2-promoting cytokine receptors in patients with allergic disease. The Journal of allergy and clinical immunology. 2013;133(4): 952-60. PMID: 24084078 | PMCID: PMC3969406
  • Wisniewski J, Agrawal R, Minnicozzi S, Xin W, Patrie J, Heymann P, Workman L, Platts-Mills T, Song T, Moloney M, Woodfolk J. Sensitization to food and inhalant allergens in relation to age and wheeze among children with atopic dermatitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2013;43(10): 1160-70. PMID: 24074334 | PMCID: PMC3801418
  • Platts-Mills T, Woodfolk J. Allergens and their role in the allergic immune response. Immunological reviews. 2011;242(1): 51-68. PMID: 21682738
  • Hulse K, Reefer A, Engelhard V, Patrie J, Ziegler S, Chapman M, Woodfolk J. Targeting allergen to FcgammaRI reveals a novel T(H)2 regulatory pathway linked to thymic stromal lymphopoietin receptor. The Journal of allergy and clinical immunology. 2010;125(1): 247-56.e1-8. PMID: 20109752 | PMCID: PMC2814452
  • Reefer A, Hulse K, Lannigan J, Solga M, Wright P, Kelly L, Patrie J, Chapman M, Woodfolk J. Flow cytometry imaging identifies rare T(H)2 cells expressing thymic stromal lymphopoietin receptor in a "proallergic" milieu. The Journal of allergy and clinical immunology. 2010;126(5): 1049-58, 1058.e1-10. PMID: 20888036 | PMCID: PMC3034251