John H. Bushweller

Education

  • BA, Dartmouth College, Hanover, NH
  • PhD, University of California, Berkeley, CA
  • Postdoc, Eidgenössische Technische Hochschule, Zürich, Switzerland

Primary Appointment

  • Professor, Molecular Physiology and Biological Physics

Contact

Research Interest(s)

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Research Description

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Selected Publications

  • Regan M, Horanyi P, Pryor E, Sarver J, Cafiso D, Bushweller J. Structural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibited. Proceedings of the National Academy of Sciences of the United States of America. 2013;110(33): 13374-9. PMID: 23898196 | PMCID: PMC3746864
  • Leach B, Kuntimaddi A, Schmidt C, Cierpicki T, Johnson S, Bushweller J. Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding. Structure (London, England : 1993). 2012;21(1): 176-83. PMID: 23260655 | PMCID: PMC3545106
  • Corpora T, Roudaia L, Oo Z, Chen W, Manuylova E, Cai X, Chen M, Cierpicki T, Speck N, Bushweller J. Structure of the AML1-ETO NHR3-PKA(RIIα) complex and its contribution to AML1-ETO activity. Journal of molecular biology. 2010;402(3): 560-77. PMID: 20708017 | PMCID: PMC2945414
  • Kamikubo Y, Zhao L, Wunderlich M, Corpora T, Hyde R, Paul T, Kundu M, Garrett L, Compton S, Huang G, Wolff L, Ito Y, Bushweller J, Mulloy J, Liu P. Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1. Cancer cell. 2010;17(5): 455-68. PMID: 20478528 | PMCID: PMC2874204
  • Park S, Osmers U, Raman G, Schwantes R, Diaz M, Bushweller J. The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression . Biochemistry. 2010;49(31): 6576-86. PMID: 20677832 | PMCID: PMC2916634
  • Cierpicki T, Bielnicki J, Zheng M, Gruszczyk J, Kasterka M, Petoukhov M, Zhang A, Fernandez E, Svergun D, Derewenda U, Bushweller J, Derewenda Z. The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA. Protein science : a publication of the Protein Society. 2009;18(10): 2067-79. PMID: 19670212 | PMCID: PMC2786971
  • Cierpicki T, Risner L, Grembecka J, Lukasik S, Popovic R, Omonkowska M, Shultis D, Zeleznik-Le N, Bushweller J. Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia. Nature structural & molecular biology. 2009;17(1): 62-8. PMID: 20010842 | PMCID: PMC2908503
  • Park S, Chen W, Cierpicki T, Tonelli M, Cai X, Speck N, Bushweller J. Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity. Blood. 2009;113(15): 3558-67. PMID: 19204326 | PMCID: PMC2668852
  • Park S, Speck N, Bushweller J. The role of CBFbeta in AML1-ETO's activity. Blood. 2009;114(13): 2849-50. PMID: 19779050
  • Roudaia L, Cheney M, Manuylova E, Chen W, Morrow M, Park S, Lee C, Kaur P, Williams O, Bushweller J, Speck N. CBFbeta is critical for AML1-ETO and TEL-AML1 activity. Blood. 2009;113(13): 3070-9. PMID: 19179469 | PMCID: PMC2662647
  • Zheng M, Cierpicki T, Momotani K, Artamonov M, Derewenda U, Bushweller J, Somlyo A, Derewenda Z. On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF. BMC structural biology. 2009;9 36. PMID: 19460155 | PMCID: PMC2695464
  • Erfurth F, Popovic R, Grembecka J, Cierpicki T, Theisler C, Xia Z, Stuart T, Diaz M, Bushweller J, Zeleznik-Le N. MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression. Proceedings of the National Academy of Sciences of the United States of America. 2008;105(21): 7517-22. PMID: 18483194 | PMCID: PMC2396713
  • Zhou Y, Cierpicki T, Jimenez R, Lukasik S, Ellena J, Cafiso D, Kadokura H, Beckwith J, Bushweller J. NMR solution structure of the integral membrane enzyme DsbB: functional insights into DsbB-catalyzed disulfide bond formation. Molecular cell. 2008;31(6): 896-908. PMID: 18922471 | PMCID: PMC2622435
  • Gorczynski M, Grembecka J, Zhou Y, Kong Y, Roudaia L, Douvas M, Newman M, Bielnicka I, Baber G, Corpora T, Shi J, Sridharan M, Lilien R, Donald B, Speck N, Brown M, Bushweller J. Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFbeta. Chemistry & biology. 2007;14(10): 1186-97. PMID: 17961830
  • Liu Y, Chen W, Gaudet J, Cheney M, Roudaia L, Cierpicki T, Klet R, Hartman K, Laue T, Speck N, Bushweller J. Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity. Cancer cell. 2007;11(6): 483-97. PMID: 17560331 | PMCID: PMC1978186
  • Matheny C, Speck M, Cushing P, Zhou Y, Corpora T, Regan M, Newman M, Roudaia L, Speck C, Gu T, Griffey S, Bushweller J, Speck N. Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles. The EMBO journal. 2007;26(4): 1163-75. PMID: 17290219 | PMCID: PMC1852839
  • Cierpicki T, Kim M, Cooper D, Derewenda U, Bushweller J, Derewenda Z. The DC-module of doublecortin: dynamics, domain boundaries, and functional implications. Proteins. 2006;64(4): 874-82. PMID: 16835924
  • Cierpicki T, Liang B, Tamm L, Bushweller J. Increasing the accuracy of solution NMR structures of membrane proteins by application of residual dipolar couplings. High-resolution structure of outer membrane protein A. Journal of the American Chemical Society. 2006;128(21): 6947-51. PMID: 16719475 | PMCID: PMC2527590
  • Grembecka J, Cierpicki T, Devedjiev Y, Derewenda U, Kang B, Bushweller J, Derewenda Z. The binding of the PDZ tandem of syntenin to target proteins. Biochemistry. 2006;45(11): 3674-83. PMID: 16533050
  • Li Z, Lukasik S, Liu Y, Grembecka J, Bielnicka I, Bushweller J, Speck N. A mutation in the S-switch region of the Runt domain alters the dynamics of an allosteric network responsible for CBFbeta regulation. Journal of molecular biology. 2006;364(5): 1073-83. PMID: 17059830 | PMCID: PMC1783549
  • Liang B, Bushweller J, Tamm L. Site-directed parallel spin-labeling and paramagnetic relaxation enhancement in structure determination of membrane proteins by solution NMR spectroscopy. Journal of the American Chemical Society. 2006;128(13): 4389-97. PMID: 16569016 | PMCID: PMC3199951
  • Liu Y, Cheney M, Gaudet J, Chruszcz M, Lukasik S, Sugiyama D, Lary J, Cole J, Dauter Z, Minor W, Speck N, Bushweller J. The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity. Cancer cell. 2006;9(4): 249-60. PMID: 16616331