- Biomedical Sciences Graduate Program | John A. Hossack

John A. Hossack

Primary Appointment

  • Professor, Biomedical Engineering


Research Interest(s)

Diagnostic Ultrasound Transducers; Beam Forming and Imaging. Breast Ultrasound; Obstructive Sleep Apnea; 3D Ultrasound and Microbubbles

Research Description

This research work focuses primarily on improving the diagnostic confidence of medical ultrasound by improving image quality.

It involves improved transducers, beamforming, and image processing and is ultimately directed toward the measurement of physiologically significant parameters such as vessel elasticity.

The performance of an imaging system is limited by the weakest link in the image formation system. The recent advent of harmonic imaging has caused transducer bandwidth to become a critical issue. Increasing transducer bandwidth is one important element of this research. As transducer bandwidth improves, a number of new image signal processing schemes may be enabled. For example, images acquired using independent frequency bands may be combined so that the ultrasound speckle in each of the two images averages out to produce a reduced speckle and a more diagnostically useful image.

Another area of interest is three-dimensional imaging, which has important diagnostic relevance since it makes diagnosis more accurate and reliable. In particular, we are interested in extending work on a new method of 3-D ultrasound image acquisition which involves a modified transducer array and image motion tracking in each of three image planes to determine the position and orientation of acquired 2-D images in 3-D space.

Selected Publications

  • Wang S, Dhanaliwala A, Chen J, Hossack J. Production rate and diameter analysis of spherical monodisperse microbubbles from two-dimensional, expanding-nozzle flow-focusing microfluidic devices. Biomicrofluidics. 2014;7(1): 14103. PMID: 24403995 | PMCID: PMC3562342
  • Dixon A, Dhanaliwala A, Chen J, Hossack J. Enhanced intracellular delivery of a model drug using microbubbles produced by a microfluidic device. Ultrasound in medicine & biology. 2013;39(7): 1267-76. PMID: 23643062 | PMCID: PMC3674153
  • Wang S, Mauldin F, Klibanov A, Hossack J. Shear forces from flow are responsible for a distinct statistical signature of adherent microbubbles in large vessels. Molecular imaging. 2013;12(6): 396-408. PMID: 23981785 | PMCID: PMC4061764
  • Mauldin F, Dhanaliwala A, Patil A, Hossack J. Real-time targeted molecular imaging using singular value spectra properties to isolate the adherent microbubble signal. Physics in medicine and biology. 2012;57(16): 5275-93. PMID: 22853933 | PMCID: PMC3440015
  • Li Y, Garson C, Xu Y, Helm P, Hossack J, French B. Serial ultrasound evaluation of intramyocardial strain after reperfused myocardial infarction reveals that remote zone dyssynchrony develops in concert with left ventricular remodeling. Ultrasound in medicine & biology. 2011;37(7): 1073-86. PMID: 21640480 | PMCID: PMC3119373
  • Patil A, Rychak J, Klibanov A, Hossack J. Real-time technique for improving molecular imaging and guiding drug delivery in large blood vessels: in vitro and ex vivo results. Molecular imaging. 2011;10(4): 238-47. PMID: 21521555 | PMCID: PMC3127411
  • Phillips L, Klibanov A, Wamhoff B, Hossack J. Localized ultrasound enhances delivery of rapamycin from microbubbles to prevent smooth muscle proliferation. Journal of controlled release : official journal of the Controlled Release Society. 2011;154(1): 42-9. PMID: 21549778 | PMCID: PMC3148278
  • Phillips L, Klibanov A, Wamhoff B, Hossack J. Targeted gene transfection from microbubbles into vascular smooth muscle cells using focused, ultrasound-mediated delivery. Ultrasound in medicine & biology. 2010;36(9): 1470-80. PMID: 20800174 | PMCID: PMC2930891
  • Tlaxca J, Anderson C, Klibanov A, Lowrey B, Hossack J, Alexander J, Lawrence M, Rychak J. Analysis of in vitro transfection by sonoporation using cationic and neutral microbubbles. Ultrasound in medicine & biology. 2010;36(11): 1907-18. PMID: 20800945 | PMCID: PMC2996233
  • Patil A, Rychak J, Allen J, Klibanov A, Hossack J. Dual frequency method for simultaneous translation and real-time imaging of ultrasound contrast agents within large blood vessels. Ultrasound in medicine & biology. 2009;35(12): 2021-30. PMID: 19828229 | PMCID: PMC2790010
  • Phillips L, Klibanov A, Bowles D, Ragosta M, Hossack J, Wamhoff B. Focused in vivo delivery of plasmid DNA to the porcine vascular wall via intravascular ultrasound destruction of microbubbles. Journal of vascular research. 2009;47(3): 270-4. PMID: 19923850 | PMCID: PMC2865392
  • Song J, Klibanov A, Hossack J, Price R. Acoustic attenuation by contrast agent microbubbles in superficial tissue markedly diminishes petechiae bioeffects in deep tissue. Investigative radiology. 2008;43(5): 322-9. PMID: 18424953 | PMCID: PMC2714264
  • French B, Li Y, Klibanov A, Yang Z, Hossack J. 3D perfusion mapping in post-infarct mice using myocardial contrast echocardiography. Ultrasound in medicine & biology. 2006;32(6): 805-15. PMID: 16785003