- Biomedical Sciences Graduate Program | Jogender Tushir Singh

Jogender Tushir Singh

Education

  • PhD, University of Notre Dame
  • Postdoc, University of Massachusetts Medical School
  • Senior Staff Fellowship, AbbVie Inc.
  • Senior Staff Fellowship, Boehringer Ingelheim Pharmaceuticals, Inc.

Primary Appointment

  • Assistant Professor, Biochemistry and Molecular Genetics

Contact

Research Interest(s)

Tailored fit targeting approaches: Cancer Immunotherapy, Bispecific Antibodies, Antibody-siRNA conjugates, Application in Cancer therapeutics

Research Description

1. Cancer Immunotherapy and multi targeting antibodies 2. Antibody Conjugates and their applications in ovarian, triple negative breast, and other solid cancers. 3. Rational antibody design and tailored to fit targeting

Highly motivated students at all levels who are excited to study Antibody engineering, Cancer Biology and their clinical applications are welcome to join our team. Please contact directly via email "jogi@virginia.edu".

visit us

https://sites.google.com/a/virginia.edu/tushir-singh-s-laboratory-at-university-of-virginia/home

Selected Publications

  • Tushir-Singh J, Bhatnagar S. In Vitro Assay to Study Histone Ubiquitination During Transcriptional Regulation. Methods in molecular biology (Clifton, N.J.). 2016;1507 235-244. PMID: 27832544
  • Bhatnagar S, Gazin C, Chamberlain L, Ou J, Zhu X, Tushir J, Virbasius C, Lin L, Zhu L, Wajapeyee N, Green M. TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein. Nature. 2014;516(7529): 116-20. PMID: 25470042 | PMCID: PMC4269325
  • Bharadwaj R, Jiang Y, Mao W, Jakovcevski M, Dincer A, Krueger W, Garbett K, Whittle C, Tushir J, Liu J, Sequeira A, Vawter M, Gardner P, Casaccia P, Rasmussen T, Bunney W, Mirnics K, Futai K, Akbarian S. Conserved chromosome 2q31 conformations are associated with transcriptional regulation of GAD1 GABA synthesis enzyme and altered in prefrontal cortex of subjects with schizophrenia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013;33(29): 11839-51. PMID: 23864674 | PMCID: PMC3713726
  • Tushir J, Akbarian S. Chromatin-bound RNA and the neurobiology of psychiatric disease. Neuroscience. 2013;264 131-41. PMID: 23831425 | PMCID: PMC3844067
  • Shulha H, Crisci J, Reshetov D, Tushir J, Cheung I, Bharadwaj R, Chou H, Houston I, Peter C, Mitchell A, Yao W, Myers R, Chen J, Preuss T, Rogaev E, Jensen J, Weng Z, Akbarian S. Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. PLoS biology. 2012;10(11): e1001427. PMID: 23185133 | PMCID: PMC3502543
  • Seitz H, Tushir J, Zamore P. A 5'-uridine amplifies miRNA/miRNA* asymmetry in Drosophila by promoting RNA-induced silencing complex formation. Silence. 2011;2 4. PMID: 21649885 | PMCID: PMC3127740
  • Tushir J, Clancy J, Warren A, Wrobel C, Brugge J, D'Souza-Schorey C. Unregulated ARF6 activation in epithelial cysts generates hyperactive signaling endosomes and disrupts morphogenesis. Molecular biology of the cell. 2010;21(13): 2355-66. PMID: 20462959 | PMCID: PMC2893997
  • Tushir J, Zamore P, Zhang Z. SnapShot: Fly piRNAs, PIWI proteins, and the ping-pong cycle. Cell. 2009;139(3): 634, 634.e1. PMID: 19879848
  • Tushir J, Zamore P, Zhang Z. SnapShot: mouse piRNAs, PIWI proteins, and the ping-pong cycle. Cell. 2009;139(4): 830-830.e1. PMID: 19914174
  • Tushir J, D'Souza-Schorey C. ARF6-dependent activation of ERK and Rac1 modulates epithelial tubule development. The EMBO journal. 2007;26(7): 1806-19. PMID: 17363898 | PMCID: PMC1847670
  • Palacios F, Tushir J, Fujita Y, D'Souza-Schorey C. Lysosomal targeting of E-cadherin: a unique mechanism for the down-regulation of cell-cell adhesion during epithelial to mesenchymal transitions. Molecular and cellular biology. 2004;25(1): 389-402. PMID: 15601859 | PMCID: PMC538771
  • Antibody-siRNA conjugates: drugging the undruggable for anti-leukemic therapy. Expert Opin Biol Ther.. . PMCID: 27977315