Jing Yu

Primary Appointment

  • Assistant Professor, Cell Biology

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Research Interest(s)

Mammalian kidney development

Research Description

Proper formation of epithelial architecture is integral for development and function of most organs. Research interests in the Yu laboratory focus on epithelial morphogenesis during organogenesis, using the mammalian kidney as the model system. The formation and organization of renal epithelia involves multiple mechanisms commonly employed in the formation of epithelial organs, thus provides an excellent model for the study of epithelial morphogenesis. We have recently identified that Wnt7b signaling plays critical roles in the regulation of renal collecting duct epithelium morphogenesis underlying renal cortico-medullary patterning. We will take advantage of a combination of genetic, in vitro organ and cell culture, cell biology and biochemical approaches to dissect the inter- and intra-cellular machineries mediating Wnt7b signaling in renal epithelial morphogenesis. It is our hope that our study will extend the knowledge of molecular circuits orchestrating epithelial morphogenesis and provide tools for prevention, detection and treatment of renal diseases arising from defective epithelial formation or maintenance.

Selected Publications

  • Pierzchalski K, Yu J, Norman V, Kane M. CrbpI regulates mammary retinoic acid homeostasis and the mammary microenvironment. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2013. PMID: 23362116
  • Yang F, Ser W, Yu J, Foo D, Yeo D, Chia P, Wong J. Lung water detection using acoustic techniques. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. 2013;2012 4258-61. PMID: 23366868
  • Yu J, Mu X, Li R. A case of invasive pulmonary aspergillosis due to Emericella nidulans var.echinulata, successfully cured by voriconazole and micafungin. Journal of clinical microbiology. 2013. PMID: 23363828
  • Yu J, Pan Y, Ang K, Guan C, Leamy D. Prefrontal cortical activation during arithmetic processing differentiated by cultures: A preliminary fNIRS study. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. 2013;2012 4716-9. PMID: 23366981
  • Yu W, Sheng M, Xu R, Yu J, Cui K, Tong J, Shi L, Ren H, Du H. Berberine protects human renal proximal tubular cells from hypoxia/reoxygenation injury via inhibiting endoplasmic reticulum and mitochondrial stress pathways. Journal of translational medicine. 2013;11(1): 24. PMID: 23360542