- Phone: (434)924-4292
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Cell Biology and Parasitology.
Research in the Güler Malaria Lab focuses on the human-infective malaria parasite, Plasmodium falciparum. Some of our projects are described below:
·We are interested in underlying mechanisms that drive genetic change in parasites during the development of antimalarial resistance. Our studies in this area utilize a range of cellular, biochemical and molecular techniques to uncover pathways that are important for this process.
·Some genetic alterations that arise during antimalarial exposure drive metabolic adaptation in the parasite. By employing metabolite profiling to investigate these slight adjustments, we aim to reveal unique pathways that enhance parasite survival.
·We partner with researchers that work in endemic countries to apply our predictions from lab-based models to investigations with patient-isolated parasites. These studies inform our knowledge of general parasite adaptation and its effect on disease severity.
- Guler J, White J, Phillips M, Rathod P. Atovaquone tolerance in Plasmodium falciparum parasites selected for high-level resistance to a dihydroorotate dehydrogenase inhibitor. Antimicrobial agents and chemotherapy. 2014;59(1): 686-9. PMID: 25331708 | PMCID: PMC4291421
- Guler J, Freeman D, Ahyong V, Patrapuvich R, White J, Gujjar R, Phillips M, DeRisi J, Rathod P. Asexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplifications. PLoS pathogens. 2013;9(5): e1003375. PMID: 23717205 | PMCID: PMC3662640
- Narayanasamy K, Chery L, Basu A, Duraisingh M, Escalante A, Fowble J, Guler J, Herricks T, Kumar A, Majumder P, Maki J, Mascarenhas A, Rodrigues J, Roy B, Sen S, Shastri J, Smith J, Valecha N, White J, Rathod P. Malaria evolution in South Asia: knowledge for control and elimination. Acta tropica. 2012;121(3): 256-66. PMID: 22266213 | PMCID: PMC3894252
- Clayton A, Guler J, Povelones M, Gluenz E, Gull K, Smith T, Jensen R, Englund P. Depletion of mitochondrial acyl carrier protein in bloodstream-form Trypanosoma brucei causes a kinetoplast segregation defect. Eukaryotic cell. 2011;10(3): 286-92. PMID: 21239625 | PMCID: PMC3067480
- Autio K, Guler J, Kastaniotis A, Englund P, Hiltunen J. The 3-hydroxyacyl-ACP dehydratase of mitochondrial fatty acid synthesis in Trypanosoma brucei. FEBS letters. 2008;582(5): 729-33. PMID: 18258193
- Guler J, Kriegova E, Smith T, Lukes J, Englund P. Mitochondrial fatty acid synthesis is required for normal mitochondrial morphology and function in Trypanosoma brucei. Molecular microbiology. 2008;67(5): 1125-42. PMID: 18221265 | PMCID: PMC3776142