Jeffrey W. Holmes

Primary Appointment

  • Associate Professor, Biomedical Engineering


Research Interest(s)

Healing after myocardial infarction, cardiac growth and remodeling, and image-based modeling and diagnosis.

Research Description

The Cardiac Biomechanics Group focuses on the interactions between mechanics, function, and growth and remodeling in the heart. The mechanical properties of normal and diseased myocardium are important determinants of overall heart function. These mechanical properties change during growth, remodeling or disease, often in part as a response to changes in the mechanical environment. Our group studies this interplay between mechanical environment, tissue response, and heart function, not only to better understand the basis for heart disease but also to identify new opportunities to intervene.

Current Projects:

Currently, most of our projects are related to myocardial infarction (MI):

1. a translational effort to help prevent MI by developing new quantitative measures of heart wall motion that improve screening for coronary artery disease;

2. a basic biomechanics project focused on understanding how the structure of a healing infarct gives rise to its mechanical properties and how those mechanical properties influence overall heart function; and

3. longer-term efforts to determine how mechanical factors regulate both cardiac wound healing and remodeling of non-infarcted myocardium in post-MI patients

Selected Publications

  • Parker K, Clark A, Goodman N, Glover D, Holmes J. Comparison of Quantitative Wall-Motion Analysis and Strain for Detection of Coronary Stenosis with Three-Dimensional Dobutamine Stress Echocardiography. Echocardiography (Mount Kisco, N.Y.). 2014. PMID: 24815588 | PMCID: PMC4415736
  • Rouillard A, Holmes J. Mechanical boundary conditions bias fibroblast invasion in a collagen-fibrin wound model. Biophysical journal. 2014;106(4): 932-43. PMID: 24559996 | PMCID: PMC3945786
  • Haggart C, Ames E, Lee J, Holmes J. Effects of stretch and shortening on gene expression in intact myocardium. Physiological genomics. 2013;46(2): 57-65. PMID: 24302644 | PMCID: PMC3921349
  • Fomovsky G, Clark S, Parker K, Ailawadi G, Holmes J. Anisotropic reinforcement of acute anteroapical infarcts improves pump function. Circulation. Heart failure. 2012;5(4): 515-22. PMID: 22665716 | PMCID: PMC3412161
  • Fomovsky G, Rouillard A, Holmes J. Regional mechanics determine collagen fiber structure in healing myocardial infarcts. Journal of molecular and cellular cardiology. 2012;52(5): 1083-90. PMID: 22418281 | PMCID: PMC3328210
  • Rouillard A, Holmes J. Mechanical regulation of fibroblast migration and collagen remodelling in healing myocardial infarcts. The Journal of physiology. 2012;590 4585-602. PMID: 22495588 | PMCID: PMC3477759
  • Holmes J, Vande Geest J. Cardiovascular solid mechanics grows and remodels. Journal of biomechanics. 2011;45(5): 727. PMID: 22153750
  • Duan Q, Parker K, Lorsakul A, Angelini E, Hyodo E, Homma S, Holmes J, Laine A. QUANTITATIVE VALIDATION OF OPTICAL FLOW BASED MYOCARDIAL STRAIN MEASURES USING SONOMICROMETRY. Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical Imaging. 2010;2009 454-457. PMID: 20694163 | PMCID: PMC2916658
  • Fomovsky G, Macadangdang J, Ailawadi G, Holmes J. Model-based design of mechanical therapies for myocardial infarction. Journal of cardiovascular translational research. 2010;4(1): 82-91. PMID: 21088945 | PMCID: PMC3328213
  • Holmes J, Williams M. Methicillin-resistant staphylococcus aureus screening and eradication in the surgical intensive care unit: Is it worth it? American journal of surgery. 2010;200(6): 827-30; discussion 830-1. PMID: 21146028
  • Fomovsky G, Holmes J. Evolution of scar structure, mechanics, and ventricular function after myocardial infarction in the rat. American journal of physiology. Heart and circulatory physiology. 2009;298(1): H221-8. PMID: 19897714 | PMCID: PMC2806135
  • Fomovsky G, Thomopoulos S, Holmes J. Contribution of extracellular matrix to the mechanical properties of the heart. Journal of molecular and cellular cardiology. 2009;48(3): 490-6. PMID: 19686759 | PMCID: PMC2823835
  • Quinn T, Cabreriza S, Richmond M, Weinberg A, Holmes J, Spotnitz H. Simultaneous variation of ventricular pacing site and timing with biventricular pacing in acute ventricular failure improves function by interventricular assist. American journal of physiology. Heart and circulatory physiology. 2009;297(6): H2220-6. PMID: 19855057 | PMCID: PMC2793134
  • Lee W, Ingrassia C, Fung-Kee-Fung S, Costa K, Holmes J, Konofagou E. Theoretical quality assessment of myocardial elastography with in vivo validation. IEEE transactions on ultrasonics, ferroelectrics, and frequency control. 2007;54(11): 2233-45. PMID: 18051158