- Biomedical Sciences Graduate Program | Javier Provencio

Javier Provencio

Primary Appointment

  • Associate Professor, Neurology

Contact

Research Interest(s)

Innate Inflammatory Pathways Associated with Acute Aneurysmal Subarachnoid Hemorrhage

Research Description

We explore the role of myeloid cell recruitment into the central nervous system after subarachnoid hemorrhage and to determine which effector molecules in neutrophils and monocytes are responsible for the brain damage associated with delayed cerebral deterioration. Using a novel murine model of mild subarachnoid hemorrhage that allows evaluation of late cognitive effects, we have been able to show that systemic neutrophils play a role in impaired long term potentiation and memory function after SAH. We therefore have recently focused our attention on elucidating changes to the hippocampal memory mechanism after SAH. Our ultimate goal is to develop targets for treatments in patients with SAH exploiting inflammatory mechanisms.

Selected Publications

  • Le Roux P, Menon D, Citerio G, Vespa P, Bader M, Brophy G, Diringer M, Stocchetti N, Videtta W, Armonda R, Badjatia N, Bösel J, Chesnut R, Chou S, Claassen J, Czosnyka M, De Georgia M, Figaji A, Fugate J, Helbok R, Horowitz D, Hutchinson P, Kumar M, McNett M, Miller C, Naidech A, Oddo M, Olson D, O'Phelan K, Provencio J, Puppo C, Riker R, Roberson C, Schmidt M, Taccone F. The International Multidisciplinary Consensus Conference on Multimodality Monitoring in Neurocritical Care: evidentiary tables: a statement for healthcare professionals from the Neurocritical Care Society and the European Society of Intensive Care Medicine. Neurocritical care. 2015;21 S297-361. PMID: 25608916
  • Tisherman S, Bullock M, Provencio J, Rincon F. Intraoperative temperature management. Therapeutic hypothermia and temperature management. 2015;5(2): 68-72. PMID: 25992665
  • Alexander S, Provencio J. Response. Journal of neurosurgery. 2014;120(2): 384-5. PMID: 24645183
  • Brogan M, Provencio J. Spectrum of catastrophic brain injury: coma and related disorders of consciousness. Journal of critical care. 2014;29(4): 679-82. PMID: 24930368
  • Gomes J, Selim M, Cotleur A, Hussain M, Toth G, Koffman L, Asi K, Provencio J. Brain iron metabolism and brain injury following subarachnoid hemorrhage: iCeFISH-pilot (CSF iron in SAH). Neurocritical care. 2014;21(2): 285-93. PMID: 24710655 | PMCID: PMC4628549
  • Le Roux P, Menon D, Citerio G, Vespa P, Bader M, Brophy G, Diringer M, Stocchetti N, Videtta W, Armonda R, Badjatia N, Böesel J, Chesnut R, Chou S, Claassen J, Czosnyka M, De Georgia M, Figaji A, Fugate J, Helbok R, Horowitz D, Hutchinson P, Kumar M, McNett M, Miller C, Naidech A, Oddo M, Olson D, O'Phelan K, Provencio J, Puppo C, Riker R, Robertson C, Schmidt M, Taccone F. Consensus summary statement of the International Multidisciplinary Consensus Conference on Multimodality Monitoring in Neurocritical Care : a statement for healthcare professionals from the Neurocritical Care Society and the European Society of Intensive Care Medicine. Intensive care medicine. 2014;40(9): 1189-209. PMID: 25138226
  • Le Roux P, Menon D, Citerio G, Vespa P, Bader M, Brophy G, Diringer M, Stocchetti N, Videtta W, Armonda R, Badjatia N, Böesel J, Chesnut R, Chou S, Claassen J, Czosnyka M, De Georgia M, Figaji A, Fugate J, Helbok R, Horowitz D, Hutchinson P, Kumar M, McNett M, Miller C, Naidech A, Oddo M, Olson D, O'Phelan K, Provencio J, Puppo C, Riker R, Robertson C, Schmidt M, Taccone F. Consensus summary statement of the International Multidisciplinary Consensus Conference on Multimodality Monitoring in Neurocritical Care: a statement for healthcare professionals from the Neurocritical Care Society and the European Society of Intensive Care Medicine. Neurocritical care. 2014;21 S1-26. PMID: 25208678
  • Le Roux P, Menon D, Citerio G, Vespa P, Bader M, Brophy G, Diringer M, Stocchetti N, Videtta W, Armonda R, Badjatia N, Bösel J, Chesnut R, Chou S, Claassen J, Czosnyka M, De Georgia M, Figaji A, Fugate J, Helbok R, Horowitz D, Hutchinson P, Kumar M, McNett M, Miller C, Naidech A, Oddo M, Olson D, O'Phelan K, Provencio J, Puppo C, Riker R, Roberson C, Schmidt M, Taccone F. The International Multidisciplinary Consensus Conference on Multimodality Monitoring in Neurocritical Care: a list of recommendations and additional conclusions: a statement for healthcare professionals from the Neurocritical Care Society and the European Society of Intensive Care Medicine. Neurocritical care. 2014;21 S282-96. PMID: 25501689
  • Provencio J, Badjatia N. Monitoring inflammation (including fever) in acute brain injury. Neurocritical care. 2014;21 S177-86. PMID: 25315974
  • Kantor E, Bayır H, Ren D, Provencio J, Watkins L, Crago E, Horowitz M, Ferrell R, Conley Y, Alexander S. Haptoglobin genotype and functional outcome after aneurysmal subarachnoid hemorrhage. Journal of neurosurgery. 2013;120(2): 386-90. PMID: 24286153 | PMCID: PMC4544750
  • Provencio J, Da Silva I, Manno E. Intracerebral hemorrhage: new challenges and steps forward. Neurosurgery clinics of North America. 2013;24(3): 349-59. PMID: 23809030
  • da Silva I, Provencio J. Intracerebral hemorrhage in patients receiving oral anticoagulation therapy. Journal of intensive care medicine. 2013;30(2): 63-78. PMID: 23753250
  • Inflammation in subarachnoid hemorrhage and delayed deterioration associated with vasospasm: a review. Acta neurochirurgica. Supplement. 2012;115 233-8. PMID: 22890674 | PMCID: PMC3597075
  • Smithason S, Moore S, Provencio J. Low-dose lipopolysaccharide injection prior to subarachnoid hemorrhage modulates Delayed Deterioration associated with vasospasm in subarachnoid hemorrhage. Acta neurochirurgica. Supplement. 2012;115 253-8. PMID: 22890677 | PMCID: PMC3597088
  • Smithason S, Moore S, Provencio J. Systemic administration of LPS worsens delayed deterioration associated with vasospasm after subarachnoid hemorrhage through a myeloid cell-dependent mechanism. Neurocritical care. 2011;16(2): 327-34. PMID: 22090172 | PMCID: PMC3314149
  • Spiotta A, Provencio J, Rasmussen P, Manno E. Brain monitoring after subarachnoid hemorrhage: lessons learned. Neurosurgery. 2011;69(4): 755-66; discussion 766. PMID: 21508881
  • Provencio J, Altay T, Smithason S, Moore S, Ransohoff R. Depletion of Ly6G/C(+) cells ameliorates delayed cerebral vasospasm in subarachnoid hemorrhage. Journal of neuroimmunology. 2010;232(1): 94-100. PMID: 21059474 | PMCID: PMC3053416
  • Altay T, Smithason S, Volokh N, Rasmussen P, Ransohoff R, Provencio J. A novel method for subarachnoid hemorrhage to induce vasospasm in mice. Journal of neuroscience methods. 2009;183(2): 136-40. PMID: 19576247 | PMCID: PMC2769994
  • Provencio J, Fu X, Siu A, Rasmussen P, Hazen S, Ransohoff R. CSF neutrophils are implicated in the development of vasospasm in subarachnoid hemorrhage. Neurocritical care. 2009;12(2): 244-51. PMID: 19967568 | PMCID: PMC2844469
  • Mashaly H, Provencio J. Inflammation as a link between brain injury and heart damage: the model of subarachnoid hemorrhage. Cleveland Clinic journal of medicine. 2008;75 S26-30. PMID: 18540142
  • Moskowitz S, Ahrens C, Provencio J, Chow M, Rasmussen P. Prehemorrhage statin use and the risk of vasospasm after aneurysmal subarachnoid hemorrhage. Surgical neurology. 2008;71(3): 311-7, discussion 317-8. PMID: 18423529 | PMCID: PMC2971680
  • Zakaria A, Provencio J, Lopez G. Emerging subspecialties in neurology: neurocritical care. Neurology. 2008;70(18): e68-9. PMID: 18443303
  • Subarachnoid hemorrhage: a model for heart-brain interactions. Cleveland Clinic journal of medicine. 2007;74 S86-90. PMID: 17455552
  • Bell R, Powers B, Brock D, Provencio J, Flanders A, Benetiz R, Rosenwasser R, Strause J, Frazer G, Kramer M, Hesson D, Barnitz J, Osterholm J. Ventriculo-lumbar perfusion in acute ischemic stroke. Neurocritical care. 2006;5(1): 21-9. PMID: 16960290
  • Boissy A, Provencio J, Smith C, Diringer M. Neurointensivists' opinions about death by neurological criteria and organ donation. Neurocritical care. 2005;3(2): 115-21. PMID: 16174879
  • Provencio J, Kivisäkk P, Tucky B, Luciano M, Ransohoff R. Comparison of ventricular and lumbar cerebrospinal fluid T cells in non-inflammatory neurological disorder (NIND) patients. Journal of neuroimmunology. 2005;163(1): 179-84. PMID: 15885320
  • Provencio J, Vora N. Subarachnoid hemorrhage and inflammation: bench to bedside and back. Seminars in neurology. 2005;25(4): 435-44. PMID: 16341999
  • Lessons from the medical and surgical ICU. Cleveland Clinic journal of medicine. 2004;71 S19-21. PMID: 14964476
  • Deogaonkar A, Gupta R, DeGeorgia M, Sabharwal V, Gopakumaran B, Schubert A, Provencio J. Bispectral Index monitoring correlates with sedation scales in brain-injured patients. Critical care medicine. 2004;32(12): 2403-6. PMID: 15599143
  • Patel V, Heinel L, Provencio J, Vinall P, Kramer M, Rosenwasser R. Validation of image analysis for enzyme histochemical and immunocytochemical staining. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2002;77(4): 213-21. PMID: 12503731
  • Provencio J, Bleck T, Connors A. Critical care neurology. American journal of respiratory and critical care medicine. 2001;164(3): 341-5. PMID: 11500331
  • Katsetos C, Kontogeorgos G, Geddes J, Herman M, Tsimara-Papastamatiou H, Yu Y, Sakkas L, Tsokos M, Patchefsky A, Ehya H, Cooper H, Provencio J, Spano A, Frankfurter A. Differential distribution of the neuron-associated class III beta-tubulin in neuroendocrine lung tumors. Archives of pathology & laboratory medicine. 2000;124(4): 535-44. PMID: 10747310
  • Karkavelas G, Katsetos C, Geddes J, Herman M, Vinores S, Cooper H, Provencio J, Frankfurter A. Class III beta-tubulin isotype (beta III) in the adrenal medulla: II. Localization in primary human pheochromocytomas. The Anatomical record. 1998;250(3): 344-50. PMID: 9517851
  • Katsetos C, Karkavelas G, Herman M, Vinores S, Provencio J, Spano A, Frankfurter A. Class III beta-tubulin isotype (beta III) in the adrenal medulla: I. Localization in the developing human adrenal medulla. The Anatomical record. 1998;250(3): 335-43. PMID: 9517850