James W. Mandell


  • AB, Cornell University
  • PhD, Cornell University
  • MD, Cornell University
  • Postdoc, University of Virginia

Primary Appointment

  • Associate Professor, Pathology


Research Interest(s)

Identification of Novel Biomarkers for Inflammatory Myopathies

Research Description

Selected Publications

  • Sokolowski J, Chabanon-Hicks C, Han C, Heffron D, Mandell J. Fractalkine is a "find-me" signal released by neurons undergoing ethanol-induced apoptosis. Frontiers in cellular neuroscience. 2014;8 360. PMID: 25426022 | PMCID: PMC4224129
  • Sokolowski J, Gamage K, Heffron D, Leblanc A, Deppmann C, Mandell J. Caspase-mediated cleavage of actin and tubulin is a common feature and sensitive marker of axonal degeneration in neural development and injury. Acta neuropathologica communications. 2014;2 16. PMID: 24507707 | PMCID: PMC3996144
  • Hochreiter-Hufford A, Lee C, Kinchen J, Sokolowski J, Arandjelovic S, Call J, Klibanov A, Yan Z, Mandell J, Ravichandran K. Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion. Nature. 2013;497(7448): 263-7. PMID: 23615608 | PMCID: PMC3773542
  • Sokolowski J, Mandell J. Phagocytic clearance in neurodegeneration. The American journal of pathology. 2011;178(4): 1416-28. PMID: 21435432 | PMCID: PMC3078427
  • Daubert E, Heffron D, Mandell J, Condron B. Serotonergic dystrophy induced by excess serotonin. Molecular and cellular neurosciences. 2010;44(3): 297-306. PMID: 20394820 | PMCID: PMC2878889
  • Sokolowski J, Nobles S, Heffron D, Park D, Ravichandran K, Mandell J. Brain-specific angiogenesis inhibitor-1 expression in astrocytes and neurons: implications for its dual function as an apoptotic engulfment receptor. Brain, behavior, and immunity. 2010;25(5): 915-21. PMID: 20888903 | PMCID: PMC3033447
  • Glass G, Papin J, Mandell J. SIMPLE: a sequential immunoperoxidase labeling and erasing method. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2009;57(10): 899-905. PMID: 19365090 | PMCID: PMC2746723
  • Heffron D, Landreth G, Samuels I, Mandell J. Brain-specific deletion of extracellular signal-regulated kinase 2 mitogen-activated protein kinase leads to aberrant cortical collagen deposition. The American journal of pathology. 2009;175(6): 2586-99. PMID: 19893051 | PMCID: PMC2789603
  • Immunohistochemical assessment of protein phosphorylation state: the dream and the reality. Histochemistry and cell biology. 2008;130(3): 465-71. PMID: 18648845 | PMCID: PMC2522329
  • Correa-Cerro L, Mandell J. Molecular mechanisms of astrogliosis: new approaches with mouse genetics. Journal of neuropathology and experimental neurology. 2007;66(3): 169-76. PMID: 17356378
  • Favero C, Mandell J. A pharmacological activator of AMP-activated protein kinase (AMPK) induces astrocyte stellation. Brain research. 2007;1168 1-10. PMID: 17706943 | PMCID: PMC2000700
  • Park D, Tosello-Trampont A, Elliott M, Lu M, Haney L, Ma Z, Klibanov A, Mandell J, Ravichandran K. BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature. 2007;450(7168): 430-4. PMID: 17960134
  • Bourne T, Mandell J, Matsumoto J, Jane J, Lopes M. Primary disseminated leptomeningeal oligodendroglioma with 1p deletion. Case report. Journal of neurosurgery. 2006;105(6): 465-9. PMID: 17184079
  • Hamilton D, Bourne T, Ahmed H, Cousar J, Mandell J, Sheehan J. Follicular lymphoma of the dura: case report. Neurosurgery. 2006;59(3): E703-4; discussion E703-4. PMID: 16955025
  • McFarland K, Wilkes S, Koss S, Ravichandran K, Mandell J. Neural-specific inactivation of ShcA results in increased embryonic neural progenitor apoptosis and microencephaly. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006;26(30): 7885-97. PMID: 16870734