James W. Mandell


  • AB, Cornell University
  • PhD, Cornell University
  • MD, Cornell University
  • Postdoc, University of Virginia

Primary Appointment

  • Associate Professor, Pathology


Research Interest(s)

Mechanisms of Brain Astroglial Activation in Neural Injury

Research Description

Selected Publications

  • Louis R, Yen C, Mohila C, Mandell J, Sheehan J. A rare intraosseous arteriovenous malformation of the spine. Journal of neurosurgery. Spine. 2011;15(3): 336-9. PMID: 21663404
  • Sokolowski J, Mandell J. Phagocytic clearance in neurodegeneration. The American journal of pathology. 2011;178(4): 1416-28. PMID: 21435432 | PMCID: PMC3078427
  • Bourne T, Elias W, Lopes M, Mandell J. WT1 is not a reliable marker to distinguish reactive from neoplastic astrocyte populations in the central nervous system. Brain pathology (Zurich, Switzerland). 2010;20(6): 1090-5. PMID: 20576027
  • Daubert E, Heffron D, Mandell J, Condron B. Serotonergic dystrophy induced by excess serotonin. Molecular and cellular neurosciences. 2010;44(3): 297-306. PMID: 20394820 | PMCID: PMC2878889
  • Sokolowski J, Nobles S, Heffron D, Park D, Ravichandran K, Mandell J. Brain-specific angiogenesis inhibitor-1 expression in astrocytes and neurons: implications for its dual function as an apoptotic engulfment receptor. Brain, behavior, and immunity. 2010;25(5): 915-21. PMID: 20888903 | PMCID: PMC3033447
  • Crowley R, Sansur C, Sheehan J, Mandell J, Kassell N, Dumont A. Intracranial plasmacytoma with apoplectic presentation and spontaneous intracerebral hemorrhage: Case report and review of the literature. Clinical neurology and neurosurgery. 2009;112(2): 172-5. PMID: 20031303
  • Glass G, Papin J, Mandell J. SIMPLE: a sequential immunoperoxidase labeling and erasing method. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2009;57(10): 899-905. PMID: 19365090 | PMCID: PMC2746723
  • Heffron D, Landreth G, Samuels I, Mandell J. Brain-specific deletion of extracellular signal-regulated kinase 2 mitogen-activated protein kinase leads to aberrant cortical collagen deposition. The American journal of pathology. 2009;175(6): 2586-99. PMID: 19893051 | PMCID: PMC2789603
  • Mandell J, Glass G, Gianchandani E, Locke C, Amos S, Bourne T, Schiff D, Papin J. Dephosphorylation of beta-arrestin 1 in glioblastomas. Journal of neuropathology and experimental neurology. 2009;68(5): 535-41. PMID: 19404096
  • Immunohistochemical assessment of protein phosphorylation state: the dream and the reality. Histochemistry and cell biology. 2008;130(3): 465-71. PMID: 18648845 | PMCID: PMC2522329
  • Correa-Cerro L, Mandell J. Molecular mechanisms of astrogliosis: new approaches with mouse genetics. Journal of neuropathology and experimental neurology. 2007;66(3): 169-76. PMID: 17356378
  • Favero C, Mandell J. A pharmacological activator of AMP-activated protein kinase (AMPK) induces astrocyte stellation. Brain research. 2007;1168 1-10. PMID: 17706943 | PMCID: PMC2000700
  • Park D, Tosello-Trampont A, Elliott M, Lu M, Haney L, Ma Z, Klibanov A, Mandell J, Ravichandran K. BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature. 2007;450(7168): 430-4. PMID: 17960134
  • Policarpio-Nicolas M, Le B, Mandell J, Lopes M. Granular cell tumor of the neurohypophysis: report of a case with intraoperative cytologic diagnosis. Diagnostic cytopathology. 2007;36(1): 58-63. PMID: 18064694
  • Bourne T, Mandell J, Matsumoto J, Jane J, Lopes M. Primary disseminated leptomeningeal oligodendroglioma with 1p deletion. Case report. Journal of neurosurgery. 2006;105(6): 465-9. PMID: 17184079
  • Hamilton D, Bourne T, Ahmed H, Cousar J, Mandell J, Sheehan J. Follicular lymphoma of the dura: case report. Neurosurgery. 2006;59(3): E703-4; discussion E703-4. PMID: 16955025
  • McFarland K, Wilkes S, Koss S, Ravichandran K, Mandell J. Neural-specific inactivation of ShcA results in increased embryonic neural progenitor apoptosis and microencephaly. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006;26(30): 7885-97. PMID: 16870734