James P. Nataro

Education

  • MD, University of Maryland
  • PhD, University of Maryland
  • MBA, University of Maryland

Primary Appointment

  • Professor, Pediatrics

Contact

Research Interest(s)

Pathogenesis of diarrheagenic Escherichia coli and Shigella.

Research Description

Dr. Nataro's multi-disciplinary research program focuses on enteric bacterial infections, principally diarrheagenic E. coli and Shigella spp. His seminal observations include the discovery of enteroaggregative and diffusely adherent E. coli pathotypes, the introduction of the first molecular probe for enteropathogenic E. coli, the discovery of a large number of virulence factors and mechanisms, and the construction of several vaccine candidates. He has made pivotal contributions to understanding the roles of diarrheagenic E. coli in human disease. Dr. Nataro has trained a large number of undergraduate, graduate, medical (including three MD/PhD students), as well as many post-doctoral fellows and junior faculty. While Head, Division of Infectious Diseases and Tropical Pediatrics at the University of Maryland, he mentored several young faculty to their first NIH awards.

Selected Publications

  • Donnenberg M, Hazen T, Farag T, Panchalingam S, Antonio M, Hossain A, Mandomando I, Ochieng J, Ramamurthy T, Tamboura B, Zaidi A, Levine M, Kotloff K, Rasko D, Nataro J. Bacterial Factors Associated with Lethal Outcome of Enteropathogenic Escherichia coli Infection: Genomic Case-Control Studies. PLoS neglected tropical diseases. 2015;9(5): e0003791. PMID: 25978422 | PMCID: PMC4433268
  • Boisen N, Hansen A, Melton-Celsa A, Zangari T, Mortensen N, Kaper J, O'Brien A, Nataro J. The presence of the pAA plasmid in the German O104:H4 Shiga toxin type 2a (Stx2a)-producing enteroaggregative Escherichia coli strain promotes the translocation of Stx2a across an epithelial cell monolayer. The Journal of infectious diseases. 2014;210(12): 1909-19. PMID: 25038258 | PMCID: PMC4296181
  • Mullick S, Mukherjee A, Ghosh S, Pazhani G, Sur D, Manna B, Nataro J, Levine M, Ramamurthy T, Chawla-Sarkar M. Community based case-control study of rotavirus gastroenteritis among young children during 2008-2010 reveals vast genetic diversity and increased prevalence of G9 strains in Kolkata. PloS one. 2014;9(11): e112970. PMID: 25401757 | PMCID: PMC4234499
  • Bolick D, Roche J, Hontecillas R, Bassaganya-Riera J, Nataro J, Guerrant R. Enteroaggregative Escherichia coli strain in a novel weaned mouse model: exacerbation by malnutrition, biofilm as a virulence factor and treatment by nitazoxanide. Journal of medical microbiology. 2013;62 896-905. PMID: 23475903 | PMCID: PMC3709553
  • Boll E, Struve C, Sander A, Demma Z, Nataro J, McCormick B, Krogfelt K. The fimbriae of enteroaggregative Escherichia coli induce epithelial inflammation in vitro and in a human intestinal xenograft model. The Journal of infectious diseases. 2012;206(5): 714-22. PMID: 22723643
  • Del Canto F, Botkin D, Valenzuela P, Popov V, Ruiz-Perez F, Nataro J, Levine M, Stine O, Pop M, Torres A, Vidal R. Identification of Coli Surface Antigen 23, a novel adhesin of enterotoxigenic Escherichia coli. Infection and immunity. 2012;80(8): 2791-801. PMID: 22645287
  • Boisen N, Scheutz F, Rasko D, Redman J, Persson S, Simon J, Kotloff K, Levine M, Sow S, Tamboura B, Toure A, Malle D, Panchalingam S, Krogfelt K, Nataro J. Genomic characterization of enteroaggregative Escherichia coli from children in Mali. The Journal of infectious diseases. 2011;205(3): 431-44. PMID: 22184729
  • Ruiz-Perez F, Wahid R, Faherty C, Kolappaswamy K, Rodriguez L, Santiago A, Murphy E, Cross A, Sztein M, Nataro J. Serine protease autotransporters from Shigella flexneri and pathogenic Escherichia coli target a broad range of leukocyte glycoproteins. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(31): 12881-6. PMID: 21768350