James E. Casanova

Education

  • BS, Southern Connecticut State University
  • PhD, Wesleyan Univeristy
  • Postdoc, Whitehead Institute
  • Postdoc, University of California, San Francisco

Primary Appointment

  • Professor, Cell Biology

Contact

Research Interest(s)

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Research Description

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viagra for cheap from canada Cell-based studies of Salmonella infection: Salmonellae penetrate the intestinal epithelium by injecting an array of effector proteins into the cytoplasm of epithelial cells that trigger phagocytic uptake of attached bacteria. We are interested in defining the cellular targets of these effector proteins, and how their manipulation by the bacteria promotes their internalization and intracellular survival. Using yeast two-hybrid screens and shRNA screens, we have identified a number of host proteins that either interact directly with bacterial effectors or are necessary for bacterial uptake or intracellular proliferation. We recently reported that the tip of the bacterial translocation apparatus (Type III secretion system), a protein called SipC, interacts with components of the host vesicular transport machinery (the Exocyst) and directs secretory vesicles to sites of bacterial attachment, where the membrane is used to build the phagocytic apparatus. We are currently looking for graduate students/postdocs to further analyze the "hits" from these screens and determine their function in Salmonella pathogenesis.

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Selected Publications

  • Mingo R, Simmons J, Shoemaker C, Nelson E, Schornberg K, D'Souza R, Casanova J, White J. Ebola virus and severe acute respiratory syndrome coronavirus display late cell entry kinetics: evidence that transport to NPC1+ endolysosomes is a rate-defining step. Journal of virology. 2015;89(5): 2931-43. PMID: 25552710 | PMCID: PMC4325712
  • D'Souza R, Semus R, Billings E, Meyer C, Conger K, Casanova J. Rab4 Orchestrates a Small GTPase Cascade for Recruitment of Adaptor Proteins to Early Endosomes. Current biology : CB. 2014;24(11): 1187-98. PMID: 24835460 | PMCID: PMC4059052
  • Hallstrom K, Srikanth C, Agbor T, Dumont C, Peters K, Paraoan L, Casanova J, Boll E, McCormick B. PERP, a host tetraspanning membrane protein, is required for Salmonella-induced inflammation. Cellular microbiology. 2014;17(6): 843-59. PMID: 25486861
  • Owen K, Meyer C, Bouton A, Casanova J. Activation of focal adhesion kinase by Salmonella suppresses autophagy via an Akt/mTOR signaling pathway and promotes bacterial survival in macrophages. PLoS pathogens. 2014;10(6): e1004159. PMID: 24901456 | PMCID: PMC4047085
  • Casanova J, Hsu V, Jackson C, Kahn R, Roy C, Stow J, Wandinger-Ness A, Sztul E. Meeting report - Arf and Rab family G proteins. Journal of cell science. 2013;126 5313-6. PMID: 24293329
  • Moravec R, Conger K, D'Souza R, Allison A, Casanova J. BRAG2/GEP100/IQSec1 Interacts with Clathrin and Regulates α5β1 Integrin Endocytosis through Activation of ADP Ribosylation Factor 5 (Arf5). The Journal of biological chemistry. 2012;287(37): 31138-47. PMID: 22815487 | PMCID: PMC3438945
  • Myers K, Wang G, Sheng Y, Conger K, Casanova J, Zhu J. Arf6-GEF BRAG1 Regulates JNK-Mediated Synaptic Removal of GluA1-Containing AMPA Receptors: A New Mechanism for Nonsyndromic X-Linked Mental Disorder. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012;32(34): 11716-26. PMID: 22915114 | PMCID: PMC3459061
  • Das S, Owen K, Ly K, Park D, Black S, Wilson J, Sifri C, Ravichandran K, Ernst P, Casanova J. Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(5): 2136-41. PMID: 21245295 | PMCID: PMC3033312
  • Owen K, Abshire M, Tilghman R, Casanova J, Bouton A. FAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing. PloS one. 2011;6(8): e23123. PMID: 21887232 | PMCID: PMC3160839
  • Matto M, Sklan E, David N, Melamed-Book N, Casanova J, Glenn J, Aroeti B. Role for ADP ribosylation factor 1 in the regulation of hepatitis C virus replication. Journal of virology. 2010;85(2): 946-56. PMID: 21068255 | PMCID: PMC3020004
  • Kitt K, Hernández-Deviez D, Ballantyne S, Spiliotis E, Casanova J, Wilson J. Rab14 regulates apical targeting in polarized epithelial cells. Traffic (Copenhagen, Denmark). 2008;9(7): 1218-31. PMID: 18429929 | PMCID: PMC2773667
  • Ly K, Casanova J. Abelson tyrosine kinase facilitates Salmonella enterica serovar Typhimurium entry into epithelial cells. Infection and immunity. 2008;77(1): 60-9. PMID: 18936177 | PMCID: PMC2612273
  • Myers K, Casanova J. Regulation of actin cytoskeleton dynamics by Arf-family GTPases. Trends in cell biology. 2008;18(4): 184-92. PMID: 18328709 | PMCID: PMC2885709
  • PARtitioning numb. EMBO reports. 2007;8(3): 233-5. PMID: 17330067 | PMCID: PMC1808048
  • Balasubramanian N, Scott D, Castle J, Casanova J, Schwartz M. Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts. Nature cell biology. 2007;9(12): 1381-91. PMID: 18026091 | PMCID: PMC2715295
  • Cuthbert E, Davis K, Casanova J. Substrate specificities and activities of AZAP family Arf GAPs in vivo. American journal of physiology. Cell physiology. 2007;294(1): C263-70. PMID: 18003747
  • Hall B, McLean M, Davis K, Casanova J, Sligar S, Schwartz M. A fluorescence resonance energy transfer activation sensor for Arf6. Analytical biochemistry. 2007;374(2): 243-9. PMID: 18162163 | PMCID: PMC2277471
  • Ma Z, Nie Z, Luo R, Casanova J, Ravichandran K. Regulation of Arf6 and ACAP1 signaling by the PTB-domain-containing adaptor protein GULP. Current biology : CB. 2007;17(8): 722-7. PMID: 17398097 | PMCID: PMC1930157
  • There goes the neighborhood. Focus on "localized PtdIns 3,5-P2 synthesis to regulate early endosome dynamics and fusion". American journal of physiology. Cell physiology. 2006;291(2): C231-3. PMID: 16825602
  • Dunphy J, Moravec R, Ly K, Lasell T, Melancon P, Casanova J. The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins. Current biology : CB. 2006;16(3): 315-20. PMID: 16461286 | PMCID: NIHMS437917
  • Hurtado-Lorenzo A, Skinner M, El Annan J, Futai M, Sun-Wada G, Bourgoin S, Casanova J, Wildeman A, Bechoua S, Ausiello D, Brown D, Marshansky V. V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway. Nature cell biology. 2006;8(2): 124-36. PMID: 16415858
  • Shi J, Casanova J. Invasion of host cells by Salmonella typhimurium requires focal adhesion kinase and p130Cas. Molecular biology of the cell. 2006;17(11): 4698-708. PMID: 16914515 | PMCID: PMC1635395
  • Shmuel M, Santy L, Frank S, Avrahami D, Casanova J, Altschuler Y. ARNO through its coiled-coil domain regulates endocytosis at the apical surface of polarized epithelial cells. The Journal of biological chemistry. 2006;281(19): 13300-8. PMID: 16484220
  • Yoon H, Miura K, Cuthbert E, Davis K, Ahvazi B, Casanova J, Randazzo P. ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP. Journal of cell science. 2006;119 4650-66. PMID: 17077126