J. Julius Zhu

Education

  • BS, Beijing University
  • MS, Shanghai Brain Research Institute
  • PhD, University of Wisconsin Medical School

Primary Appointment

  • Associate Professor, Pharmacology

Contact

Research Interest(s)

Neural circuit mechanisms of behavior and diseases

Research Description

My students and I are interested in central neural circuits and synapses. We enjoy developing new experimental approaches that combine cutting-edge techniques, including rapid recombinant DNA delivery and replacement, multiple whole-cell recordings, two photon laser scanning and immunoelectron microscopy. These technologies allow us to decipher the molecular and cellular regulations (e.g., nanoscale Ras/MAPK signaling) of synapses in neural circuits, as well as the organization and functions (e.g., salience selection) of neural circuits. Genetic defects of many signaling molecules are linked to a number of cognitive disorders, e.g., Akt/PKB and calcineurin with schizophrenia, BRaf with cardio-facio-cutaneous syndrome, Brag/IQSec with nonsyndromic X-linked mental retardation, CaMKII with Angelman syndrome, H-Ras with Costello syndrome, p38MAPK and JNK with Alzheimer's disease, PI3K with fragile X syndrome, PTEN with autism, Cowden and Bannayan-Riley-Ruvalcaba syndromes, RasGap NF1 with neurofibromatosis, Rsk with Coffin-Lowry syndrome and X-linked mental retardation, SHP-2 with Noonan syndrome, and tuberin with tuberous sclerosis. Altered interneuronal function is a common mechanism contributing to various neurological, mental and psychiatric disorders, including autisms, epilepsy, depression, Huntington’s disease, neurofibromatosis, schizophrenia, Tourette’s syndrome and trauma. Therefore, the findings from our research should guide the future development of treatments for these insidious diseases.

Selected Publications

  • Lim C, Hoang E, Viar K, Stornetta R, Scott M, Zhu J. Pharmacological rescue of Ras signaling, GluA1-dependent synaptic plasticity, and learning deficits in a fragile X model. Genes & development. 2014;28(3): 273-89. PMID: 24493647
  • Jiang X, Wang G, Lee A, Stornetta R, Zhu J. The organization of two new cortical interneuronal circuits. Nature neuroscience. 2013;16(2): 210-8. PMID: 23313910 | PMCID: PMC3589105
  • Stornetta R, Zhu J. Ras and Rap signaling in synaptic plasticity and mental disorders. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2010;17(1): 54-78. PMID: 20431046 | PMCID: PMC3119507
  • Kielland A, Bochorishvili G, Corson J, Zhang L, Rosin D, Heggelund P, Zhu J. Activity patterns govern synapse-specific AMPA receptor trafficking between deliverable and synaptic pools. Neuron. 2009;62(1): 84-101. PMID: 19376069 | PMCID: PMC2682220
  • Hu H, Qin Y, Bochorishvili G, Zhu Y, van Aelst L, Zhu J. Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008;28(31): 7847-62. PMID: 18667617 | PMCID: PMC2553221
  • Qin Y, Zhu Y, Baumgart J, Stornetta R, Seidenman K, Mack V, van Aelst L, Zhu J. State-dependent Ras signaling and AMPA receptor trafficking. Genes & development. 2005;19(17): 2000-15. PMID: 16107614 | PMCID: PMC1199571
  • Lee A, Wang G, Jiang X, Johnson S, Hoang E, Lanté F, Stornetta R, Beenhakker M, Shen Y, Zhu J. Canonical organization of layer 1 neuron-led cortical inhibitory and disinhibitory interneuronal circuits Cerebral Cortex (Epub ahead of print). .