J. David Castle


  • BA, Carleton College, Northfield, MN
  • PhD, Rockefeller University, New York, NY
  • Postdoc, Yale Univ. Sch. of Med., New Haven, CT
  • Postdoc, Univ. of California, Berkeley, CA

Primary Appointment

  • Professor, Cell Biology


Research Interest(s)

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Research Description

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Selected Publications

  • Schiel J, Simon G, Zaharris C, Weisz J, Castle D, Wu C, Prekeris R. FIP3-endosome-dependent formation of the secondary ingression mediates ESCRT-III recruitment during cytokinesis. Nature cell biology. 2012;14(10): 1068-78. PMID: 23000966
  • Falguières T, Castle D, Gruenberg J. Regulation of the MVB pathway by SCAMP3. Traffic (Copenhagen, Denmark). 2011;13(1): 131-42. PMID: 21951651
  • Zhang J, Castle D. Regulation of fusion pore closure and compound exocytosis in neuroendocrine PC12 cells by SCAMP1. Traffic (Copenhagen, Denmark). 2011;12(5): 600-14. PMID: 21272170 | PMCID: PMC3085939
  • Sturek J, Castle J, Trace A, Page L, Castle A, Evans-Molina C, Parks J, Mirmira R, Hedrick C. An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells. The Journal of clinical investigation. 2010;120(7): 2575-89. PMID: 20530872 | PMCID: PMC2898593
  • Aoh Q, Castle A, Hubbard C, Katsumata O, Castle J. SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling. Molecular biology of the cell. 2009;20(6): 1816-32. PMID: 19158374 | PMCID: PMC2655259
  • Liao H, Zhang J, Shestopal S, Szabo G, Castle A, Castle D. Nonredundant function of secretory carrier membrane protein isoforms in dense core vesicle exocytosis. American journal of physiology. Cell physiology. 2008;294(3): C797-809. PMID: 18171723
  • Balasubramanian N, Scott D, Castle J, Casanova J, Schwartz M. Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts. Nature cell biology. 2007;9(12): 1381-91. PMID: 18026091 | PMCID: PMC2715295
  • Liao H, Ellena J, Liu L, Szabo G, Cafiso D, Castle D. Secretory carrier membrane protein SCAMP2 and phosphatidylinositol 4,5-bisphosphate interactions in the regulation of dense core vesicle exocytosis. Biochemistry. 2007;46(38): 10909-20. PMID: 17713930
  • Castle A, Castle D. Ubiquitously expressed secretory carrier membrane proteins (SCAMPs) 1-4 mark different pathways and exhibit limited constitutive trafficking to and from the cell surface. Journal of cell science. 2005;118 3769-80. PMID: 16105885
  • Liu L, Liao H, Castle A, Zhang J, Casanova J, Szabo G, Castle D. SCAMP2 interacts with Arf6 and phospholipase D1 and links their function to exocytotic fusion pore formation in PC12 cells. Molecular biology of the cell. 2005;16(10): 4463-72. PMID: 16030257 | PMCID: PMC1237056