Ira G. Schulman

Education

  • PhD, Baylor College of Medicine

Primary Appointment

  • Associate Professor, Pharmacology

Contact

Research Interest(s)

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Research Description

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Selected Publications

  • Breevoort S, Angdisen J, Schulman I. Macrophage-independent regulation of reverse cholesterol transport by liver X receptors. Arteriosclerosis, thrombosis, and vascular biology. 2014;34(8): 1650-60. PMID: 24947527 | PMCID: PMC4107336
  • Ignatova I, Schulman I. Liver X receptors and atherosclerosis: it is not all cholesterol. Arteriosclerosis, thrombosis, and vascular biology. 2014;34(2): 242-3. PMID: 24431422 | PMCID: PMC3966182
  • Kick E, Martin R, Xie Y, Flatt B, Schweiger E, Wang T, Busch B, Nyman M, Gu X, Yan G, Wagner B, Nanao M, Nguyen L, Stout T, Plonowski A, Schulman I, Ostrowski J, Kirchgessner T, Wexler R, Mohan R. Liver X Receptor (LXR) partial agonists: Biaryl pyrazoles and imidazoles displaying a preference for LXRβ Bioorganic & medicinal chemistry letters. 2014. PMID: 25435151
  • Ignatova I, Angdisen J, Moran E, Schulman I. Differential regulation of gene expression by LXRs in response to macrophage cholesterol loading. Molecular endocrinology (Baltimore, Md.). 2013;27(7): 1036-47. PMID: 23686114 | PMCID: PMC3706843
  • Leitinger N, Schulman I. Phenotypic polarization of macrophages in atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology. 2013;33(6): 1120-6. PMID: 23640492 | PMCID: PMC3745999
  • Zhang Y, Breevoort S, Angdisen J, Fu M, Schmidt D, Holmstrom S, Kliewer S, Mangelsdorf D, Schulman I. Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice. The Journal of clinical investigation. 2012;122(5): 1688-99. PMID: 22484817 | PMCID: PMC3336978
  • Cheng F, Theodorescu D, Schulman I, Lee J. In vitro transcriptomic prediction of hepatotoxicity for early drug discovery. Journal of theoretical biology. 2011;290 27-36. PMID: 21884709 | PMCID: PMC3386613
  • Nuclear receptors as drug targets for metabolic disease. Advanced drug delivery reviews. 2010;62(13): 1307-15. PMID: 20655343 | PMCID: PMC2987515
  • Bischoff E, Daige C, Petrowski M, Dedman H, Pattison J, Juliano J, Li A, Schulman I. Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice. Journal of lipid research. 2010;51(5): 900-6. PMID: 20388921 | PMCID: PMC2853457
  • Huang H, Schulman I. Regulation of metabolism by nuclear hormone receptors. Progress in molecular biology and translational science. 2010;87 1-51. PMID: 20374700
  • Cholesterol worships a new idol. Journal of molecular cell biology. 2009;1(2): 75-6. PMID: 19783832
  • Flatt B, Martin R, Wang T, Mahaney P, Murphy B, Gu X, Foster P, Li J, Pircher P, Petrowski M, Schulman I, Westin S, Wrobel J, Yan G, Bischoff E, Daige C, Mohan R. Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR). Journal of medicinal chemistry. 2009;52(4): 904-7. PMID: 19159286
  • Levin N, Bischoff E, Daige C, Thomas D, Vu C, Heyman R, Tangirala R, Schulman I. Macrophage liver X receptor is required for antiatherogenic activity of LXR agonists. Arteriosclerosis, thrombosis, and vascular biology. 2004;25(1): 135-42. PMID: 15539622
  • Li J, Pircher P, Schulman I, Westin S. Regulation of complement C3 expression by the bile acid receptor FXR. The Journal of biological chemistry. 2004;280(9): 7427-34. PMID: 15590640
  • Mootha V, Handschin C, Arlow D, Xie X, St Pierre J, Sihag S, Yang W, Altshuler D, Puigserver P, Patterson N, Willy P, Schulman I, Heyman R, Lander E, Spiegelman B. Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proceedings of the National Academy of Sciences of the United States of America. 2004;101(17): 6570-5. PMID: 15100410 | PMCID: PMC404086
  • Schulman I, Heyman R. The flip side: Identifying small molecule regulators of nuclear receptors. Chemistry & biology. 2004;11(5): 639-46. PMID: 15157874
  • Willy P, Murray I, Qian J, Busch B, Stevens W, Martin R, Mohan R, Zhou S, Ordentlich P, Wei P, Sapp D, Horlick R, Heyman R, Schulman I. Regulation of PPARgamma coactivator 1alpha (PGC-1alpha) signaling by an estrogen-related receptor alpha (ERRalpha) ligand. Proceedings of the National Academy of Sciences of the United States of America. 2004;101(24): 8912-7. PMID: 15184675 | PMCID: PMC428446
  • Pircher P, Kitto J, Petrowski M, Tangirala R, Bischoff E, Schulman I, Westin S. Farnesoid X receptor regulates bile acid-amino acid conjugation. The Journal of biological chemistry. 2003;278(30): 27703-11. PMID: 12754200
  • Wagner B, Valledor A, Shao G, Daige C, Bischoff E, Petrowski M, Jepsen K, Baek S, Heyman R, Rosenfeld M, Schulman I, Glass C. Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression. Molecular and cellular biology. 2003;23(16): 5780-9. PMID: 12897148 | PMCID: PMC166346
  • Muscat G, Wagner B, Hou J, Tangirala R, Bischoff E, Rohde P, Petrowski M, Li J, Shao G, Macondray G, Schulman I. Regulation of cholesterol homeostasis and lipid metabolism in skeletal muscle by liver X receptors. The Journal of biological chemistry. 2002;277(43): 40722-8. PMID: 12193599
  • Tangirala R, Bischoff E, Joseph S, Wagner B, Walczak R, Laffitte B, Daige C, Thomas D, Heyman R, Mangelsdorf D, Wang X, Lusis A, Tontonoz P, Schulman I. Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America. 2002;99(18): 11896-901. PMID: 12193651 | PMCID: PMC129365
  • Osburn D, Shao G, Seidel H, Schulman I. Ligand-dependent degradation of retinoid X receptors does not require transcriptional activity or coactivator interactions. Molecular and cellular biology. 2001;21(15): 4909-18. PMID: 11438648 | PMCID: PMC87210
  • Shao G, Heyman R, Schulman I. Three amino acids specify coactivator choice by retinoid X receptors. Molecular endocrinology (Baltimore, Md.). 2000;14(8): 1198-209. PMID: 10935544
  • Schulman I, Shao G, Heyman R. Transactivation by retinoid X receptor-peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimers: intermolecular synergy requires only the PPARgamma hormone-dependent activation function. Molecular and cellular biology. 1998;18(6): 3483-94. PMID: 9584188 | PMCID: PMC108929
  • Schulman I, Evans R. Retinoid receptors in development and disease. Leukemia. 1997;11 376-7. PMID: 9209395
  • Schulman I, Li C, Schwabe J, Evans R. The phantom ligand effect: allosteric control of transcription by the retinoid X receptor. Genes & development. 1997;11(3): 299-308. PMID: 9030683
  • Chakravarti D, LaMorte V, Nelson M, Nakajima T, Schulman I, Juguilon H, Montminy M, Evans R. Role of CBP/P300 in nuclear receptor signalling. Nature. 1996;383(6595): 99-103. PMID: 8779723
  • Lala D, Mukherjee R, Schulman I, Koch S, Dardashti L, Nadzan A, Croston G, Evans R, Heyman R. Activation of specific RXR heterodimers by an antagonist of RXR homodimers. Nature. 1996;383(6599): 450-3. PMID: 8837780
  • Schulman I, Juguilon H, Evans R. Activation and repression by nuclear hormone receptors: hormone modulates an equilibrium between active and repressive states. Molecular and cellular biology. 1996;16(7): 3807-13. PMID: 8668198 | PMCID: PMC231377
  • Schulman I, Chakravarti D, Juguilon H, Romo A, Evans R. Interactions between the retinoid X receptor and a conserved region of the TATA-binding protein mediate hormone-dependent transactivation. Proceedings of the National Academy of Sciences of the United States of America. 1995;92(18): 8288-92. PMID: 7667283 | PMCID: PMC41142
  • Schulman I, Bloom K. Genetic dissection of centromere function. Molecular and cellular biology. 1993;13(6): 3156-66. PMID: 8497246 | PMCID: PMC359754
  • Schulman I, Bloom K. Centromeres: an integrated protein/DNA complex required for chromosome movement. Annual review of cell biology. 1991;7 311-36. PMID: 1809349