Inchan Kwon

Education

  • PhD, California Institute of Technology

Primary Appointment

  • Assistant Professor, Chemical Engineering

Contact

Research Interest(s)

Amyloid inhibitors for Alzheimer’s disease, protein engineering, viral gene therapy, stem cell engineering, bio-inspired nanomaterials

Research Description



Proteins play important roles in all kinds of biological systems from viruses to human being. Therefore, understanding the function and structure of proteins in biological systems is a very interesting and challenging area for engineers as well as scientists. Recent advances in protein engineering tools, such as rational design, unnatural amino acid mutagenesis and high-throughput screening of proteins, facilitate design of proteins with novel structures and functions. Therefore, our research focuses on application of proteing engineering tools to design novel genetically engineered peptide/proteins that will be used to cure diseases, deliver drugs, and produce novel biomaterials.

Our group is currently working with amyloids proteins and viral gene delivery vehicles. Amyloids are featured by cross-stacked beta-sheet structure and associated with neurodegenerative diseases, such as Alzheimer's diseases and Parkinson's diseases. Our group is trying to modulate amyloid formation, which is very important for both therapeutic means to neurodegenerative diseases and understanding molecular mechanism of amyloid formation. Another main interest of our group is to engineer adeno-associated virus (AAV)-based gene delivery vehicles. AAV has been widely used in both basic research and clinical studies, due to its several favorable features including lack of pathogenicity, efficient infection of both divining- and non-dividing cells, and long-term maintenance. However, AAV-based vectors should be modified further to be used in more diverse applications. Therefore, our group is working to design more effective AAV-based vectors and to evaluate delivery of novel genes for gene therapy application.

Selected Publications

  • Jang J, Koerber J, Kim J, Asuri P, Vazin T, Bartel M, Keung A, Kwon I, Park K, Schaffer D. An evolved adeno-associated viral variant enhances gene delivery and gene targeting in neural stem cells. Molecular therapy : the journal of the American Society of Gene Therapy. 2011;19(4): 667-75. PMID: 21224831 | PMCID: PMC3070092
  • Kwon I, Choe H, Son G, Kim K. Mammalian molecular clocks. Experimental neurobiology. 2011;20(1): 18-28. PMID: 22110358 | PMCID: PMC3213736
  • Park E, Iaccarino C, Lee J, Kwon I, Baik S, Kim M, Seong J, Son G, Borrelli E, Kim K. Regulatory roles of heterogeneous nuclear ribonucleoprotein M and Nova-1 protein in alternative splicing of dopamine D2 receptor pre-mRNA. The Journal of biological chemistry. 2011;286(28): 25301-8. PMID: 21622564 | PMCID: PMC3137101
  • Takasu A, Kondo S, Ito A, Furukawa Y, Higuchi M, Kinoshita T, Kwon I. Artificial extracellular matrix proteins containing phenylalanine analogues biosynthesized in bacteria using T7 expression system and the PEGylation. Biomacromolecules. 2011;12(10): 3444-52. PMID: 21823658 | PMCID: NIHMS328250
  • Wong H, Kwon I. Xanthene food dye, as a modulator of Alzheimer's disease amyloid-beta peptide aggregation and the associated impaired neuronal cell function. PloS one. 2011;6(10): e25752. PMID: 21998691 | PMCID: PMC3187789
  • Zheng S, Kwon I. Manipulation of enzyme properties by noncanonical amino acid incorporation. Biotechnology journal. 2011;7(1): 47-60. PMID: 22121038
  • Chae S, Kwon I, Kim C, Jang J. Analysis of weight control in Korean adolescents using the transtheoretical model. Western journal of nursing research. 2010;32(4): 511-29. PMID: 20685908
  • Lee Y, Lee J, Kwon I, Nakajima Y, Ohmiya Y, Son G, Lee K, Kim K. Coactivation of the CLOCK-BMAL1 complex by CBP mediates resetting of the circadian clock. Journal of cell science. 2010;123 3547-57. PMID: 20930143
  • Mo H, Kwon I. Korean attitudes to Xenotransplantation: a survey conducted in 2009. Xenotransplantation. 2010;17(5): 391-5. PMID: 20955295