Our Faculty > Hui Zong

Hui Zong

Hui Zong

Education

  • PhD, University of Indiana

Primary Appointment

  • Associate Professor, Microbiology, Immunology, and Cancer Biology

Contact

Research Interest(s)

Mouse models of brain cancers

Research Description

Challenges in cancer biology

Cancer is the second leading cause of death in the United States. Malignant tumors are difficult to treat due to multiple molecular and cellular aberrations and their ability to undergo metastasis. These challenges demand studies on cancer as a dynamic process, with an increased focus on understanding tumor initiation and progression mechanisms. Information from such studies will allow the detection of pre-cancerous lesions to move the first line of defense prior to full-blown malignancy.

Selected Publications

  • Zong H, Raman N, Mickelson-Young L, Atkinson S, Quilliam L. Loop 6 of RhoA confers specificity for effector binding, stress fiber formation, and cellular transformation. The Journal of biological chemistry. 1999;274(8): 4551-60. PMID: 9988689
  • Zong H, Kaibuchi K, Quilliam L. The insert region of RhoA is essential for Rho kinase activation and cellular transformation. Molecular and cellular biology. 2001;21(16): 5287-98. PMID: 11463812 | PMCID: PMC87252
  • Luo L, Zong H. Single neuron labeling and genetic manipulation. Nature neuroscience. 2001;4 1158-9. PMID: 11687823
  • Muzumdar M, Luo L, Zong H. Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM). Proceedings of the National Academy of Sciences of the United States of America. 2007;104(11): 4495-500. PMID: 17360552 | PMCID: PMC1810340
  • Hippenmeyer S, Youn Y, Moon H, Miyamichi K, Zong H, Wynshaw-Boris A, Luo L. Genetic mosaic dissection of Lis1 and Ndel1 in neuronal migration. Neuron. 2010;68(4): 695-709. PMID: 21092859 | PMCID: PMC3044607
  • Liu C, Sage J, Miller M, Verhaak R, Hippenmeyer S, Vogel H, Foreman O, Bronson R, Nishiyama A, Luo L, Zong H. Mosaic analysis with double markers reveals tumor cell of origin in glioma. Cell. 2011;146(2): 209-21. PMID: 21737130 | PMCID: PMC3143261
  • Papagiannakopoulos T, Friedmann-Morvinski D, Neveu P, Dugas J, Gill R, Huillard E, Liu C, Zong H, Rowitch D, Barres B, Verma I, Kosik K. Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases. Oncogene. 2011;31(15): 1884-95. PMID: 21874051
  • Foo L, Allen N, Bushong E, Ventura P, Chung W, Zhou L, Cahoy J, Daneman R, Zong H, Ellisman M, Barres B. Development of a method for the purification and culture of rodent astrocytes. Neuron. 2011;71(5): 799-811. PMID: 21903074 | PMCID: PMC3172573
  • Tasic B, Hippenmeyer S, Wang C, Gamboa M, Zong H, Chen-Tsai Y, Luo L. Site-specific integrase-mediated transgenesis in mice via pronuclear injection. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(19): 7902-7. PMID: 21464299 | PMCID: PMC3093482
  • Liu C, Zong H. Developmental origins of brain tumors. Current opinion in neurobiology. 2012;22(5): 844-9. PMID: 22560511 | PMCID: PMC3432164
  • Zong H, Verhaak R, Canolk P. The cellular origin for malignant glioma and prospects for clinical advancements. Expert review of molecular diagnostics. 2012;12(4): 383-94. PMID: 22616703 | PMCID: PMC3368274
  • Tasic B, Miyamichi K, Hippenmeyer S, Dani V, Zeng H, Joo W, Zong H, Chen-Tsai Y, Luo L. Extensions of MADM (mosaic analysis with double markers) in mice. PloS one. 2012;7(3): e33332. PMID: 22479386 | PMCID: PMC3314016
  • Gay L, Miller M, Ventura P, Devasthali V, Vue Z, Thompson H, Temple S, Zong H, Cleary M, Stankunas K, Doe C. Mouse TU tagging: a chemical/genetic intersectional method for purifying cell type-specific nascent RNA. Genes & development. 2013;27(1): 98-115. PMID: 23307870