Howard C. Kutchai


  • PhD, University of Virginia

Primary Appointment

  • Professor, Molecular Physiology and Biological Physics


Research Interest(s)

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Research Description

buy viagraa online canada We are studying the effects of novel synthetic compounds that significantly increase the activity of SERCA2a.  We will characterize the effects of these compounds on contractility in hearts of normal mice and in mice subjected to experimental myocardial infarction and determine whether the compounds can ameliorate the rhythm disturbances that occur following heart attack.

Selected Publications

  • Mahaney J, Albers R, Waggoner J, Kutchai H, Froehlich J. Intermolecular conformational coupling and free energy exchange enhance the catalytic efficiency of cardiac muscle SERCA2a following the relief of phospholamban inhibition. Biochemistry. 2005;44(21): 7713-24. PMID: 15909986
  • Rembold C, Ripley M, Meeks M, Geddis L, Kutchai H, Marassi F, Cheung J, Moorman J. Serine 68 phospholemman phosphorylation during forskolin-induced swine carotid artery relaxation. Journal of vascular research. 2005;42(6): 483-91. PMID: 16155364 | PMCID: PMC1266286
  • Reddy S, Mistry D, Wang Q, Geddis L, Kutchai H, Moorman J, Mounsey J. Effects of age and gene dose on skeletal muscle sodium channel gating in mice deficient in myotonic dystrophy protein kinase. Muscle & nerve. 2002;25(6): 850-7. PMID: 12115974