Helmy M. Siragy


  • Fellowship, The University of Texas Health Science Center at San Antonio
  • Fellowship, University of Virginia
  • Residency, University of Texas, Galveston
  • MD, Tanta University

Primary Appointment

  • Professor, Medicine- Endocrinology and Metabolism


Research Interest(s)

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Research Description

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Selected Publications

  • Quadri S, Siragy H. Regulation of (pro)renin receptor expression in mIMCD via the GSK-3β-NFAT5-SIRT-1 signaling pathway. American journal of physiology. Renal physiology. 2014;307(5): F593-600. PMID: 24990896
  • Huang J, Ledford K, Pitkin W, Russo L, Najjar S, Siragy H. Targeted deletion of murine CEACAM 1 activates PI3K-Akt signaling and contributes to the expression of (Pro)renin receptor via CREB family and NF-κB transcription factors. Hypertension. 2013;62(2): 317-23. PMID: 23734002 | PMCID: PMC3793251
  • Matavelli L, Huang J, Siragy H. In vivo regulation of renal expression of (pro)renin receptor by a low-sodium diet. American journal of physiology. Renal physiology. 2012;303(12): F1652-7. PMID: 23077099 | PMCID: PMC3532474
  • Matavelli L, Siragy H. Reduction of aldosterone production improves renal oxidative stress and fibrosis in diabetic rats. Journal of cardiovascular pharmacology. 2012;61(1): 17-22. PMID: 23011470 | PMCID: PMC3538933
  • Waeber B, Siragy H. Mild hypertension: to treat or not to treat? Current hypertension reports. 2012;15(1): 1-2. PMID: 23152161
  • A current evaluation of the safety of angiotensin receptor blockers and direct renin inhibitors. Vascular health and risk management. 2011;7 297-313. PMID: 21633727 | PMCID: PMC3104607
  • Rationale for combining a direct renin inhibitor with other renin- angiotensin system blockers. Focus on aliskiren and combinations. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. 2011;25(1): 87-97. PMID: 21213120
  • To ACCELERATE hypertension control. Current hypertension reports. 2011;13(4): 259-61. PMID: 21494776
  • Abadir P, Walston J, Carey R, Siragy H. Angiotensin II Type-2 receptors modulate inflammation through signal transducer and activator of transcription proteins 3 phosphorylation and TNFα production. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2011;31(6): 471-4. PMID: 21288138 | PMCID: PMC3104285
  • Huang J, Matavelli L, Siragy H. Renal (pro)renin receptor contributes to development of diabetic kidney disease through transforming growth factor-β1-connective tissue growth factor signalling cascade. Clinical and experimental pharmacology & physiology. 2011;38(4): 215-21. PMID: 21265872 | PMCID: PMC3077929
  • Huang J, Siragy H. Sodium depletion enhances renal expression of (pro)renin receptor via cyclic GMP-protein kinase G signaling pathway. Hypertension. 2011;59(2): 317-23. PMID: 22203739 | PMCID: PMC3266459
  • Matavelli L, Huang J, Siragy H. Combined aliskiren and amlodipine reduce albuminuria via reduction in renal inflammation in diabetic rats. Journal of cardiovascular pharmacology. 2011;59(3): 281-7. PMID: 22075749 | PMCID: PMC3296909