- Biomedical Sciences Graduate Program | Heather Ferris

Heather Ferris

Education

  • PhD, University of Virginia
  • MD, University of Virginia
  • Residency, University of Pittsburgh Medical Center
  • Clinical Fellowship, Beth Israel Deaconess Medical Center

Primary Appointment

  • Clinician and Investigator, Medicine- Endocrinology and Metabolism

Contact

Research Interest(s)

The Role of Diabetes in Cognitive Decline

Research Description

People living with both Type 1 and Type 2 diabetes are at increased risk for cognitive decline and Alzheimer's disease. Our research uses both cell and animal models to study the impact of diabetes on the brain. In particular, we are interested in:

1. How insulin regulates cholesterol synthesis in the different cell types of the brain and how this impacts brain energetics. 2. The potential role of oxidized lipids in the brain in diabetes. 3. Understanding the role of insulin in the pathogenesis of Alzheimer's disease.

Selected Publications

  • Ferris H, Isganaitis E, Brown F. Time for an End to Juice in the Special Supplemental Nutrition Program for Women, Infants, and Children. JAMA pediatrics. 2017. PMID: 28437541
  • Ferris H, Perry R, Moreira G, Shulman G, Horton J, Kahn C. Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism. Proceedings of the National Academy of Sciences of the United States of America. 2017;114(5): 1189-1194. PMID: 28096339 | PMCID: PMC5293102
  • Ferris H, Kahn C. Unraveling the Paradox of Selective Insulin Resistance in the Liver: the Brain-Liver Connection. Diabetes. 2016;65(6): 1481-3. PMID: 27222392 | PMCID: PMC4878421
  • Fukui K, Ferris H, Kahn C. Effect of cholesterol reduction on receptor signaling in neurons. The Journal of biological chemistry. 2016;291(30): 15910. PMID: 27451432 | PMCID: PMC4957072
  • Fukui K, Ferris H, Kahn C. Effect of cholesterol reduction on receptor signaling in neurons. The Journal of biological chemistry. 2015;290(44): 26383-92. PMID: 26370080 | PMCID: PMC4646295
  • Kleinridders A, Ferris H, Cai W, Kahn C. Insulin action in brain regulates systemic metabolism and brain function. Diabetes. 2014;63(7): 2232-43. PMID: 24931034 | PMCID: PMC4066341
  • Ferris H, Williams G, Parker J, Garber J. Therapeutic implications of diffuse hepatic uptake following I-131 therapy for differentiated thyroid cancer. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2013;19(2): 263-7. PMID: 23529347
  • Suzuki R, Ferris H, Chee M, Maratos-Flier E, Kahn C. Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function. PLoS biology. 2013;11(4): e1001532. PMID: 23585733 | PMCID: PMC3621654
  • Ferris H, Kahn C. New mechanisms of glucocorticoid-induced insulin resistance: make no bones about it. The Journal of clinical investigation. 2012;122(11): 3854-7. PMID: 23093783 | PMCID: PMC3484465
  • Ferris H, Hunt S. Destination ventricular assist devices for heart failure #205. Journal of palliative medicine. 2009;12(10): 956-7. PMID: 19807242
  • Ferris H, Walsh H, Stevens J, Fallest P, Shupnik M. Luteinizing hormone beta promoter stimulation by adenylyl cyclase and cooperation with gonadotropin-releasing hormone 1 in transgenic mice and LBetaT2 Cells. Biology of reproduction. 2007;77(6): 1073-80. PMID: 17699734
  • Ferris H, Shupnik M. Mechanisms for pulsatile regulation of the gonadotropin subunit genes by GNRH1. Biology of reproduction. 2006;74(6): 993-8. PMID: 16481592