Gordon W. Laurie


  • BS, McMaster University
  • MS, McGill University, Montreal, P.Q., CANADA
  • PhD, McGill University, Montreal, P.Q., CANADA

Primary Appointment

  • Professor, Cell Biology


Research Interest(s)

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Research Description

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Selected Publications

  • McKown R, Coleman Frazier E, Zadrozny K, Deleault A, Raab R, Ryan D, Sia R, Lee J, Laurie G. A cleavage-potentiated fragment of tear lacritin is bactericidal. The Journal of biological chemistry. 2014;289(32): 22172-82. PMID: 24942736 | PMCID: PMC4139230
  • Vijmasi T, Chen F, Balasubbu S, Gallup M, McKown R, Laurie G, McNamara N. Topical administration of lacritin is a novel therapy for aqueous-deficient dry eye disease. Investigative ophthalmology & visual science. 2014;55(8): 5401-9. PMID: 25034600 | PMCID: PMC4148924
  • McKown R, Raab R, Kachelries P, Caldwell S, Laurie G. Conserved regional 3' grouping of rare codons in the coding sequence of ocular prosecretory mitogen lacritin. Investigative ophthalmology & visual science. 2013;54(3): 1979-87. PMID: 23422824 | PMCID: PMC3604909
  • Velez V F, Romano J, McKown R, Green K, Zhang L, Raab R, Ryan D, Hutnik C, Frierson H, Laurie G. Tissue transglutaminase is a negative regulator of monomeric lacritin bioactivity. Investigative ophthalmology & visual science. 2013;54(3): 2123-32. PMID: 23425695 | PMCID: PMC3621506
  • Wang N, Zimmerman K, Raab R, McKown R, Hutnik C, Talla V, Tyler M, Lee J, Laurie G. Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism. The Journal of biological chemistry. 2013;288(25): 18146-61. PMID: 23640897 | PMCID: PMC3689958
  • Zhang Y, Wang N, Raab R, McKown R, Irwin J, Kwon I, van Kuppevelt T, Laurie G. Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity. The Journal of biological chemistry. 2013;288(17): 12090-101. PMID: 23504321 | PMCID: PMC3636894
  • Laurie D, Splan R, Green K, Still K, McKown R, Laurie G. Detection of prosecretory mitogen lacritin in nonprimate tears primarily as a C-terminal-like fragment. Investigative ophthalmology & visual science. 2012;53(10): 6130-6. PMID: 22871838 | PMCID: PMC3441044
  • Seifert K, Gandia N, Wilburn J, Bower K, Sia R, Ryan D, Deaton M, Still K, Vassilev V, Laurie G, McKown R. Tear lacritin levels by age, sex, and time of day in healthy adults. Investigative ophthalmology & visual science. 2012;53(10): 6610-6. PMID: 22918641 | PMCID: PMC3460390
  • Samudre S, Lattanzio F, Lossen V, Hosseini A, Sheppard J, McKown R, Laurie G, Williams P. Lacritin, a novel human tear glycoprotein, promotes sustained basal tearing and is well tolerated. Investigative ophthalmology & visual science. 2010;52(9): 6265-70. PMID: 21087963 | PMCID: PMC3176019
  • Ma P, Beck S, Raab R, McKown R, Coffman G, Utani A, Chirico W, Rapraeger A, Laurie G. Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin. The Journal of cell biology. 2006;174(7): 1097-106. PMID: 16982797 | PMCID: PMC1666580
  • Wang J, Wang N, Xie J, Walton S, McKown R, Raab R, Ma P, Beck S, Coffman G, Hussaini I, Laurie G. Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways. The Journal of cell biology. 2006;174(5): 689-700. PMID: 16923831 | PMCID: PMC1761701
  • Ozyildirim A, Wistow G, Gao J, Wang J, Dickinson D, Frierson H, Laurie G. The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts. Investigative ophthalmology & visual science. 2005;46(5): 1572-80. PMID: 15851553
  • Faisal Khan K, Laurie G, McCaffrey T, Falcone D. Exposure of cryptic domains in the alpha 1-chain of laminin-1 by elastase stimulates macrophages urokinase and matrix metalloproteinase-9 expression. The Journal of biological chemistry. 2002;277(16): 13778-86. PMID: 11827968
  • Sanghi S, Kumar R, Lumsden A, Dickinson D, Klepeis V, Trinkaus-Randall V, Frierson H, Laurie G. cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland. Journal of molecular biology. 2001;310(1): 127-39. PMID: 11419941
  • Wang W, Jashnani A, Aluri S, Gustafson J, Hsueh P, Yarber F, McKown R, Laurie G, Hamm-Alvarez S, MacKay J. A thermo-responsive protein treatment for dry eyes J Control Release. 199 156-167. PMCID: PMC4456095