- MSc, CCMB, Jawaharlal Nehru University, New Delhi, Indi
- PhD, State University of New York at Stony Brook
- Assistant Professor, Medicine- Infectious Diseases and International Health
- Phone: 434-243-7243
- Email: firstname.lastname@example.org
Iron-uptake mechanisms and Virulence Factors of Francisella tularensis; Microbial Pathogenesis
Tularemia is a plague-like disease caused by the bacterium Francisella tularensis. This organism is highly infectious as an aerosol and an effective vaccine for the agent does not currently exist. My major research interest is in mechanisms governing pathogenicity of this intracellular pathogen. Acquisition of iron in the host environment is a challenge for the pathogen, and we are studying the mechanisms for acquisition of iron using a combination of bioinformatics, genetic and proteomic methods. Defining iron uptake and utilization mechanisms could lead to development of vaccine and therapeutic strategies. We are characterizing a siderophore-mediated uptake mechanism, and are also looking at transcriptional regulation of bacterial genes in response to iron.
A second research interest is the histone deacetylases of the protozoan parasite, Entamoeba histolytica. I am interested in studying these enzymes with the goal of therapeutic intervention using specific inhibitors.
Girija Ramakrishnan is an affiliated faculty member of the Microbiology, Immunology and Infectious Diseases program.
- Nazarko T, Ozeki K, Till A, Ramakrishnan G, Lotfi P, Yan M, Subramani S. Peroxisomal Atg37 binds Atg30 or palmitoyl-CoA to regulate phagophore formation during pexophagy. The Journal of cell biology. 2014;204(4): 541-57. PMID: 24535825
- Ramakrishnan G, Sen B. The FupA/B protein uniquely facilitates transport of ferrous iron and siderophore-mediated ferric iron across the outer membrane of Francisella tularensis Live Vaccine Strain. Microbiology (Reading, England). 2013. PMID: 24307666
- Ramakrishnan G, Sen B, Johnson R. Paralogous outer membrane proteins mediate uptake of different forms of iron and synergistically govern virulence in Francisella tularensis tularensis. The Journal of biological chemistry. 2012;287(30): 25191-202. PMID: 22661710 | PMCID: PMC3408188