Gilbert Kinsey

Education

  • PhD, Medical University of South Carolina
  • PharmD, Medical University of South Carolina

Primary Appointment

  • Assistant Professor, Medicine- Nephrology

Contact

Research Interest(s)

Acute Kidney Injury, Regulatory T Cells, Innate Immune Response

Research Description

The goal of our laboratory is to develop treatments that will either prevent or treat acute kidney injury (AKI). AKI by itself is detrimental in terms of morbidity and mortality and increases the likelihood of chronic and end-stage renal disease. An uncontrolled immune response (inflammation) in the injured kidney is a common mechanism leading to AKI. Our recent studies have demonstrated that anti-inflammatory cells of the immune system called regulatory T cells (Tregs) protect the kidney from AKI in an animal model. We are currently exploring the mechanisms used by Tregs to protect the kidney with the intention of discovering or developing therapies that mimic the beneficial actions of Tregs in kidney injury.

Selected Publications

  • Myeloid Cell HO-ming in AKI. Journal of the American Society of Nephrology : JASN. 2015. PMID: 25677391
  • Bajwa A, Rosin D, Chroscicki P, Lee S, Dondeti K, Ye H, Kinsey G, Stevens B, Jobin K, Kenwood B, Hoehn K, Lynch K, Okusa M. Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury. Journal of the American Society of Nephrology : JASN. 2014. PMID: 25145931
  • Jaworska K, Ratajczak J, Huang L, Whalen K, Yang M, Stevens B, Kinsey G. Both PD-1 ligands protect the kidney from ischemia reperfusion injury. Journal of immunology (Baltimore, Md. : 1950). 2014;194(1): 325-33. PMID: 25404361 | PMCID: PMC4272874
  • Macrophage dynamics in AKI to CKD progression. Journal of the American Society of Nephrology : JASN. 2013;25(2): 209-11. PMID: 24309186 | PMCID: PMC3904577
  • Kinsey G, Okusa M. Expanding role of T cells in acute kidney injury. Current opinion in nephrology and hypertension. 2013;23(1): 9-16. PMID: 24231312 | PMCID: PMC3909711
  • Kinsey G, Sharma R, Okusa M. Regulatory T cells in AKI. Journal of the American Society of Nephrology : JASN. 2013;24(11): 1720-6. PMID: 24136922 | PMCID: PMC3810092
  • Kinsey G, Huang L, Jaworska K, Khutsishvili K, Becker D, Ye H, Lobo P, Okusa M. Autocrine adenosine signaling promotes regulatory T cell-mediated renal protection. Journal of the American Society of Nephrology : JASN. 2012;23(9): 1528-37. PMID: 22835488 | PMCID: PMC3431416
  • Kinsey G, Okusa M. Role of leukocytes in the pathogenesis of acute kidney injury. Critical care (London, England). 2012;16(2): 214. PMID: 22429752 | PMCID: PMC3681359
  • Li L, Huang L, Ye H, Song S, Bajwa A, Lee S, Moser E, Jaworska K, Kinsey G, Day Y, Linden J, Lobo P, Rosin D, Okusa M. Dendritic cells tolerized with adenosine A₂AR agonist attenuate acute kidney injury. The Journal of clinical investigation. 2012;122(11): 3931-42. PMID: 23093781 | PMCID: PMC3484444
  • Awad A, Kinsey G, Khutsishvili K, Gao T, Bolton W, Okusa M. Monocyte/macrophage chemokine receptor CCR2 mediates diabetic renal injury. American journal of physiology. Renal physiology. 2011;301(6): F1358-66. PMID: 21880831 | PMCID: PMC3233863
  • Blum J, Kinsey G, Monian P, Sun B, Cummings B, McHowat J, Schnellmann R. Profiling of fatty acids released during calcium-induced mitochondrial permeability transition in isolated rabbit kidney cortex mitochondria. Toxicology in vitro : an international journal published in association with BIBRA. 2011;25(5): 1001-6. PMID: 21443943 | PMCID: PMC3109228
  • Kinsey G, Okusa M. Pathogenesis of acute kidney injury: foundation for clinical practice. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2011;58(2): 291-301. PMID: 21530035 | PMCID: PMC3144267
  • Kinsey G, Huang L, Vergis A, Li L, Okusa M. Regulatory T cells contribute to the protective effect of ischemic preconditioning in the kidney. Kidney international. 2010;77(9): 771-80. PMID: 20164824 | PMCID: PMC2912287
  • Bajwa A, Kinsey G, Okusa M. Immune mechanisms and novel pharmacological therapies of acute kidney injury. Current drug targets. 2009;10(12): 1196-204. PMID: 19715538 | PMCID: PMC2941672
  • Kinsey G, Sharma R, Huang L, Li L, Vergis A, Ye H, Ju S, Okusa M. Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury. Journal of the American Society of Nephrology : JASN. 2009;20(8): 1744-53. PMID: 19497969 | PMCID: PMC2723989
  • Kinsey G, Blum J, Covington M, Cummings B, McHowat J, Schnellmann R. Decreased iPLA2gamma expression induces lipid peroxidation and cell death and sensitizes cells to oxidant-induced apoptosis. Journal of lipid research. 2008;49(7): 1477-87. PMID: 18398221 | PMCID: PMC2431104
  • Kinsey G, Li L, Okusa M. Inflammation in acute kidney injury. Nephron. Experimental nephrology. 2008;109(4): e102-7. PMID: 18802372 | PMCID: PMC2614446
  • Zhuang S, Kinsey G, Rasbach K, Schnellmann R. Heparin-binding epidermal growth factor and Src family kinases in proliferation of renal epithelial cells. American journal of physiology. Renal physiology. 2008;294(3): F459-68. PMID: 18171996
  • Zhuang S, Kinsey G, Yan Y, Han J, Schnellmann R. Extracellular signal-regulated kinase activation mediates mitochondrial dysfunction and necrosis induced by hydrogen peroxide in renal proximal tubular cells. The Journal of pharmacology and experimental therapeutics. 2008;325(3): 732-40. PMID: 18339970
  • Kinsey G, McHowat J, Patrick K, Schnellmann R. Role of Ca2+-independent phospholipase A2gamma in Ca2+-induced mitochondrial permeability transition. The Journal of pharmacology and experimental therapeutics. 2007;321(2): 707-15. PMID: 17312185
  • Kinsey G, McHowat J, Beckett C, Schnellmann R. Identification of calcium-independent phospholipase A2gamma in mitochondria and its role in mitochondrial oxidative stress. American journal of physiology. Renal physiology. 2006;292(2): F853-60. PMID: 17047165
  • Lock E, Reed C, Kinsey G, Schnellmann R. Caspase-dependent and -independent induction of phosphatidylserine externalization during apoptosis in human renal carcinoma Cak(1)-1 and A-498 cells. Toxicology. 2006;229(1): 79-90. PMID: 17097791
  • Kinsey G, Cummings B, Beckett C, Saavedra G, Zhang W, McHowat J, Schnellmann R. Identification and distribution of endoplasmic reticulum iPLA2. Biochemical and biophysical research communications. 2005;327(1): 287-93. PMID: 15629460
  • Cummings B, Gelasco A, Kinsey G, McHowat J, Schnellmann R. Inactivation of endoplasmic reticulum bound Ca2+-independent phospholipase A2 in renal cells during oxidative stress. Journal of the American Society of Nephrology : JASN. 2004;15(6): 1441-51. PMID: 15153555
  • Cummings B, Kinsey G, Bolchoz L, Schnellmann R. Identification of caspase-independent apoptosis in epithelial and cancer cells. The Journal of pharmacology and experimental therapeutics. 2004;310(1): 126-34. PMID: 15028782