Erik L. Hewlett


  • BA, Westminster College, Missouri
  • MD, Johns Hopkins University School of Medicine

Primary Appointment

  • Professor, Medicine- Infectious Diseases and International Health


Research Interest(s)

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Selected Publications

  • Hewlett E, Burns D, Cotter P, Harvill E, Merkel T, Quinn C, Stibitz E. Pertussis pathogenesis--what we know and what we don't know. The Journal of infectious diseases. 2014;209(7): 982-5. PMID: 24626533
  • D'Auria K, Kolling G, Donato G, Warren C, Gray M, Hewlett E, Papin J. In vivo physiological and transcriptional profiling reveals host responses to Clostridium difficile toxin A and toxin B. Infection and immunity. 2013;81(10): 3814-24. PMID: 23897615 | PMCID: PMC3811747
  • Eby J, Gray M, Warfel J, Paddock C, Jones T, Day S, Bowden J, Poulter M, Donato G, Merkel T, Hewlett E. Quantification of the adenylate cyclase toxin of Bordetella pertussis in vitro and during respiratory infection. Infection and immunity. 2013;81(5): 1390-8. PMID: 23429530 | PMCID: PMC3648026
  • Masin J, Fiser R, Linhartova I, Osicka R, Bumba L, Hewlett E, Benz R, Sebo P. Differences in Purinergic Amplification of Osmotic Cell Lysis by the Pore-Forming RTX Toxins Bordetella pertussis CyaA and Actinobacillus pleuropneumoniae ApxIA: The Role of Pore Size. Infection and immunity. 2013. PMID: 24082076 | PMCID: PMC3837988
  • Chavali A, D'Auria K, Hewlett E, Pearson R, Papin J. A metabolic network approach for the identification and prioritization of antimicrobial drug targets. Trends in microbiology. 2012;20(3): 113-23. PMID: 22300758 | PMCID: PMC3299924
  • D'Auria K, Donato G, Gray M, Kolling G, Warren C, Cave L, Solga M, Lannigan J, Papin J, Hewlett E. Systems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control. BMC systems biology. 2012;6 2. PMID: 22225989 | PMCID: PMC3266197
  • Donato G, Goldsmith C, Paddock C, Eby J, Gray M, Hewlett E. Delivery of Bordetella pertussis adenylate cyclase toxin to target cells via outer membrane vesicles. FEBS letters. 2012;586(4): 459-65. PMID: 22289177 | PMCID: PMC3288663
  • Henderson M, Inatsuka C, Sheets A, Williams C, Benaron D, Donato G, Gray M, Hewlett E, Cotter P. Contribution of Bordetella filamentous hemagglutinin and adenylate cyclase toxin to suppression and evasion of interleukin-17-mediated inflammation. Infection and immunity. 2012;80(6): 2061-75. PMID: 22473603 | PMCID: PMC3370597
  • Eby J, Gray M, Mangan A, Donato G, Hewlett E. Role of CD11b/CD18 in the process of intoxication by the adenylate cyclase toxin of Bordetella pertussis. Infection and immunity. 2011;80(2): 850-9. PMID: 22144488 | PMCID: PMC3264305