Edward Perez-Reyes


  • BA, University of North Carolina
  • PhD, University of Colorado, Denver
  • Research Fellowship, Stanford University

Primary Appointment

  • Professor, Pharmacology


Research Interest(s)

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Research Description

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Selected Publications

  • Dey D, Eckle V, Vitko I, Sullivan K, Lasiecka Z, Winckler B, Stornetta R, Williamson J, Kapur J, Perez-Reyes E. A potassium leak channel silences hyperactive neurons and ameliorates status epilepticus. Epilepsia. 2013;55(2): 203-13. PMID: 24299204 | PMCID: PMC4161023
  • Eckle V, Shcheglovitov A, Vitko I, Dey D, Yap C, Winckler B, Perez-Reyes E. Mechanisms by which a CACNA1H mutation in epilepsy patients increases seizure susceptibility. The Journal of physiology. 2013;592 795-809. PMID: 24277868 | PMCID: PMC3934715
  • Shcheglovitov A, Vitko I, Lazarenko R, Orestes P, Todorovic S, Perez-Reyes E. Molecular and biophysical basis of glutamate and trace metal modulation of voltage-gated Ca(v)2.3 calcium channels. The Journal of general physiology. 2012;139(3): 219-34. PMID: 22371363 | PMCID: PMC3289959
  • Hargus N, Jennings C, Perez-Reyes E, Bertram E, Patel M. Enhanced actions of adenosine in medial entorhinal cortex layer II stellate neurons in temporal lobe epilepsy are mediated via A(1)-receptor activation. Epilepsia. 2011;53(1): 168-76. PMID: 22126400 | PMCID: PMC3253213
  • Characterization of the gating brake in the I-II loop of CaV3 T-type calcium channels. Channels (Austin, Tex.). 2010;4(6): 453-8. PMID: 21099341 | PMCID: PMC3052245
  • Arias-Olguín I, Vitko I, Fortuna M, Baumgart J, Sokolova S, Shumilin I, Van Deusen A, Soriano-García M, Gomora J, Perez-Reyes E. Characterization of the gating brake in the I-II loop of Ca(v)3.2 T-type Ca(2+) channels. The Journal of biological chemistry. 2008;283(13): 8136-44. PMID: 18218623 | PMCID: PMC2276388
  • Baumgart J, Vitko I, Bidaud I, Kondratskyi A, Lory P, Perez-Reyes E. I-II loop structural determinants in the gating and surface expression of low voltage-activated calcium channels. PloS one. 2008;3(8): e2976. PMID: 18714336 | PMCID: PMC2495038
  • Shcheglovitov A, Vitko I, Bidaud I, Baumgart J, Navarro-Gonzalez M, Grayson T, Lory P, Hill C, Perez-Reyes E. Alternative splicing within the I-II loop controls surface expression of T-type Ca(v)3.1 calcium channels. FEBS letters. 2008;582(27): 3765-70. PMID: 18930057 | PMCID: PMC2614674
  • Vitko I, Shcheglovitov A, Baumgart J, Arias-Olguín I, Murbartián J, Arias J, Perez-Reyes E. Orientation of the calcium channel beta relative to the alpha(1)2.2 subunit is critical for its regulation of channel activity. PloS one. 2008;3(10): e3560. PMID: 18958281 | PMCID: PMC2570331
  • Vitko I, Chen Y, Arias J, Shen Y, Wu X, Perez-Reyes E. Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005;25(19): 4844-55. PMID: 15888660