Edward H. Egelman


  • BA, Brandeis University, Waltham, MA
  • PhD, Brandeis University, Waltham, MA
  • Postdoc, MRC Lab. of Mol. Biology, Cambridge, UK

Primary Appointment

  • Professor, Biochemistry and Molecular Genetics


Research Interest(s)

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Research Description

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Selected Publications

  • Lu A, Magupalli V, Ruan J, Yin Q, Atianand M, Vos M, Schröder G, Fitzgerald K, Wu H, Egelman E. Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell. 2014;156(6): 1193-206. PMID: 24630722 | PMCID: PMC4000066
  • Pang X, Fan J, Zhang Y, Zhang K, Gao B, Ma J, Li J, Deng Y, Zhou Q, Egelman E, Hsu V, Sun F. A PH Domain in ACAP1 Possesses Key Features of the BAR Domain in Promoting Membrane Curvature. Developmental cell. 2014;31(1): 73-86. PMID: 25284369 | PMCID: PMC4198613
  • Wu B, Peisley A, Tetrault D, Li Z, Egelman E, Magor K, Walz T, Penczek P, Hur S. Molecular imprinting as a signal-activation mechanism of the viral RNA sensor RIG-I. Molecular cell. 2014;55(4): 511-23. PMID: 25018021 | PMCID: PMC4142144
  • Qiao Q, Yang C, Zheng C, Fontán L, David L, Yu X, Bracken C, Rosen M, Melnick A, Egelman E, Wu H. Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly. Molecular cell. 2013;51(6): 766-79. PMID: 24074955 | PMCID: PMC3929958
  • Berke I, Yu X, Modis Y, Egelman E. MDA5 assembles into a polar helical filament on dsRNA. Proceedings of the National Academy of Sciences of the United States of America. 2012;109(45): 18437-41. PMID: 23090998 | PMCID: PMC3494895
  • Galkin V, Orlova A, Egelman E. Actin filaments as tension sensors. Current biology : CB. 2012;22(3): R96-101. PMID: 22321312 | PMCID: PMC3277726
  • Galkin V, Orlova A, Egelman E. Are ParM Filaments Polar or Bipolar? Journal of molecular biology. 2012;423(4): 482-5. PMID: 22922064 | PMCID: PMC3467344
  • Yu X, Goforth C, Meyer C, Rachel R, Wirth R, Schröder G, Egelman E. Filaments from Ignicoccus hospitalis show diversity of packing in proteins containing N-terminal type IV pilin helices. Journal of molecular biology. 2012;422(2): 274-81. PMID: 22659006 | PMCID: PMC3599786
  • Galkin V, Orlova A, Kudryashov D, Solodukhin A, Reisler E, Schröder G, Egelman E. Remodeling of actin filaments by ADF/cofilin proteins. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(51): 20568-72. PMID: 22158895 | PMCID: PMC3251117
  • Orlova A, Galkin V, Jeffries C, Egelman E, Trewhella J. The N-terminal domains of myosin binding protein C can bind polymorphically to F-actin. Journal of molecular biology. 2011;412(3): 379-86. PMID: 21821050 | PMCID: PMC3167005
  • Implications of the RecA structure. F1000 biology reports. 2010;1 7. PMID: 20948618 | PMCID: PMC2920672
  • Galkin V, Orlova A, Schröder G, Egelman E. Structural polymorphism in F-actin. Nature structural & molecular biology. 2010;17(11): 1318-23. PMID: 20935633 | PMCID: PMC2988880
  • Grintsevich E, Galkin V, Orlova A, Ytterberg A, Mikati M, Kudryashov D, Loo J, Egelman E, Reisler E. Mapping of drebrin binding site on F-actin. Journal of molecular biology. 2010;398(4): 542-54. PMID: 20347847 | PMCID: PMC2866048
  • Yu X, Egelman E. Helical filaments of human Dmc1 protein on single-stranded DNA: a cautionary tale. Journal of molecular biology. 2010;401(3): 544-51. PMID: 20600108 | PMCID: PMC2917623
  • Problems in fitting high resolution structures into electron microscopic reconstructions. HFSP journal. 2009;2(6): 324-31. PMID: 19436497 | PMCID: PMC2645587
  • Galkin V, Orlova A, Rivera C, Mullins R, Egelman E. Structural polymorphism of the ParM filament and dynamic instability. Structure (London, England : 1993). 2009;17(9): 1253-64. PMID: 19748346 | PMCID: PMC2745721
  • Lucarelli D, Wang Y, Galkin V, Yu X, Wigley D, Egelman E. The RecB nuclease domain binds to RecA-DNA filaments: implications for filament loading. Journal of molecular biology. 2009;391(2): 269-74. PMID: 19540850 | PMCID: PMC2749006
  • Makhov A, Sen A, Yu X, Simon M, Griffith J, Egelman E. The bipolar filaments formed by herpes simplex virus type 1 SSB/recombination protein (ICP8) suggest a mechanism for DNA annealing. Journal of molecular biology. 2009;386(2): 273-9. PMID: 19138689 | PMCID: PMC2757162
  • Frost A, Perera R, Roux A, Spasov K, Destaing O, Egelman E, De Camilli P, Unger V. Structural basis of membrane invagination by F-BAR domains. Cell. 2008;132(5): 807-17. PMID: 18329367 | PMCID: PMC2384079
  • Galkin V, Orlova A, Brieher W, Kueh H, Mitchison T, Egelman E. Coronin-1A stabilizes F-actin by bridging adjacent actin protomers and stapling opposite strands of the actin filament. Journal of molecular biology. 2008;376(3): 607-13. PMID: 18177666 | PMCID: PMC2267021
  • Galkin V, Orlova A, Cherepanova O, Lebart M, Egelman E. High-resolution cryo-EM structure of the F-actin-fimbrin/plastin ABD2 complex. Proceedings of the National Academy of Sciences of the United States of America. 2008;105(5): 1494-8. PMID: 18234857 | PMCID: PMC2234172
  • Huang R, Wang Y, Roth R, Yu X, Purvis A, Heuser J, Egelman E, Sadler J. Assembly of Weibel-Palade body-like tubules from N-terminal domains of von Willebrand factor. Proceedings of the National Academy of Sciences of the United States of America. 2008;105(2): 482-7. PMID: 18182488 | PMCID: PMC2206562
  • Zhang X, Galkin V, Yu X, Egelman E, Heyer W. Loop 2 in Saccharomyces cerevisiae Rad51 protein regulates filament formation and ATPase activity. Nucleic acids research. 2008;37(1): 158-71. PMID: 19033358 | PMCID: PMC2615628
  • Single-particle reconstruction from EM images of helical filaments. Current opinion in structural biology. 2007;17(5): 556-61. PMID: 17851070 | PMCID: PMC2443787
  • Bugreev D, Yu X, Egelman E, Mazin A. Novel pro- and anti-recombination activities of the Bloom's syndrome helicase. Genes & development. 2007;21(23): 3085-94. PMID: 18003860 | PMCID: PMC2081975
  • Shvetsov A, Galkin V, Orlova A, Phillips M, Bergeron S, Rubenstein P, Egelman E, Reisler E. Actin hydrophobic loop 262-274 and filament nucleation and elongation. Journal of molecular biology. 2007;375(3): 793-801. PMID: 18037437 | PMCID: NIHMS38812