Douglas A. Bayliss

Education

  • PhD, University of North Carolina
  • MSc, University of Guelph
  • BS, University of Guelph

Primary Appointment

  • Professor, Pharmacology

Contact

Research Interest(s)

Mechanisms of neuromodulation in central neurons

Research Description

Signaling between cells in the brain relies on electrical and chemical transmission. Ion channels traverse brain cell membranes to serve as conduits for the flow of ionic current, which creates the potential differences across the membrane that are ultimately responsible for triggering release of chemical messengers that act on nearby neurons.

Our laboratory attempts to characterize neuronal signaling in terms of identifying the molecular basis for neuronal ion channels and understanding cellular mechanisms that modulate their activity. We are particularly interested in studying those ion channels that determine intrinsic excitability of brain cells, because they are often subject to regulation by endogenous neurochemicals and since they ultimately mediate effects of many drugs, therapeutic and otherwise.

A number of technical approaches are employed in our laboratory, including chemical neuroanatomy, cellular electrophysiology in brain tissue and transfected cells, molecular biology and in vivo gene transfer. Our hope is that information combined from these different approaches will illuminate mechanisms responsible for physiological and pharmacological modulation of neuronal excitability.

Selected Publications

  • Wang S, Benamer N, Zanella S, Kumar N, Shi Y, B√©vengut M, Penton D, Guyenet P, Lesage F, Gestreau C, Barhanin J, Bayliss D. TASK-2 channels contribute to pH sensitivity of retrotrapezoid nucleus chemoreceptor neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013;33(41): 16033-44. PMID: 24107938 | PMCID: PMC3792448
  • Wang S, Shi Y, Shu S, Guyenet P, Bayliss D. Phox2b-expressing retrotrapezoid neurons are intrinsically responsive to H+ and CO2. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013;33(18): 7756-61. PMID: 23637167 | PMCID: PMC3707793
  • Zhou C, Douglas J, Kumar N, Shu S, Bayliss D, Chen X. Forebrain HCN1 channels contribute to hypnotic actions of ketamine. Anesthesiology. 2013;118(4): 785-95. PMID: 23377220 | PMCID: PMC3605219
  • Guagliardo N, Yao J, Hu C, Schertz E, Tyson D, Carey R, Bayliss D, Barrett P. TASK-3 channel deletion in mice recapitulates low-renin essential hypertension. Hypertension. 2012;59(5): 999-1005. PMID: 22493079 | PMCID: PMC3357084
  • Sandilos J, Bayliss D. Physiological mechanisms for the modulation of pannexin 1 channel activity. The Journal of physiology. 2012;590 6257-66. PMID: 23070703 | PMCID: PMC3533187
  • Sandilos J, Chiu Y, Chekeni F, Armstrong A, Walk S, Ravichandran K, Bayliss D. Pannexin 1, an ATP release channel, is activated by caspase cleavage of its pore-associated C terminal autoinhibitory region. The Journal of biological chemistry. 2012. PMID: 22311983 | PMCID: PMC3322839
  • Chekeni F, Elliott M, Sandilos J, Walk S, Kinchen J, Lazarowski E, Armstrong A, Penuela S, Laird D, Salvesen G, Isakson B, Bayliss D, Ravichandran K. Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature. 2010;467(7317): 863-7. PMID: 20944749 | PMCID: PMC3006164
  • Lazarenko R, Fortuna M, Shi Y, Mulkey D, Takakura A, Moreira T, Guyenet P, Bayliss D. Anesthetic activation of central respiratory chemoreceptor neurons involves inhibition of a THIK-1-like background K(+) current. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010;30(27): 9324-34. PMID: 20610767 | PMCID: PMC2910363
  • Lazarenko R, Willcox S, Shu S, Berg A, Jevtovic-Todorovic V, Talley E, Chen X, Bayliss D. Motoneuronal TASK channels contribute to immobilizing effects of inhalational general anesthetics. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010;30(22): 7691-704. PMID: 20519544 | PMCID: PMC2909781
  • Chen X, Shu S, Bayliss D. HCN1 channel subunits are a molecular substrate for hypnotic actions of ketamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009;29(3): 600-9. PMID: 19158287 | PMCID: PMC2744993
  • Bayliss D, Barrett P. Emerging roles for two-pore-domain potassium channels and their potential therapeutic impact. Trends in pharmacological sciences. 2008;29(11): 566-75. PMID: 18823665 | PMCID: PMC2777628
  • Davies L, Hu C, Guagliardo N, Sen N, Chen X, Talley E, Carey R, Bayliss D, Barrett P. TASK channel deletion in mice causes primary hyperaldosteronism. Proceedings of the National Academy of Sciences of the United States of America. 2008;105(6): 2203-8. PMID: 18250325 | PMCID: PMC2538899
  • Berg A, Sen N, Bayliss D. TrpC3/C7 and Slo2.1 are molecular targets for metabotropic glutamate receptor signaling in rat striatal cholinergic interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007;27(33): 8845-56. PMID: 17699666
  • Mulkey D, Talley E, Stornetta R, Siegel A, West G, Chen X, Sen N, Mistry A, Guyenet P, Bayliss D. TASK channels determine pH sensitivity in select respiratory neurons but do not contribute to central respiratory chemosensitivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007;27(51): 14049-58. PMID: 18094244
  • Chen X, Talley E, Patel N, Gomis A, McIntire W, Dong B, Viana F, Garrison J, Bayliss D. Inhibition of a background potassium channel by Gq protein alpha-subunits. Proceedings of the National Academy of Sciences of the United States of America. 2006;103(9): 3422-7. PMID: 16492788 | PMCID: PMC1413874
  • Murbarti√°n J, Lei Q, Sando J, Bayliss D. Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels. The Journal of biological chemistry. 2005;280(34): 30175-84. PMID: 16006563
  • Berg A, Talley E, Manger J, Bayliss D. Motoneurons express heteromeric TWIK-related acid-sensitive K+ (TASK) channels containing TASK-1 (KCNK3) and TASK-3 (KCNK9) subunits. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004;24(30): 6693-702. PMID: 15282272
  • Mulkey D, Stornetta R, Weston M, Simmons J, Parker A, Bayliss D, Guyenet P. Respiratory control by ventral surface chemoreceptor neurons in rats. Nature neuroscience. 2004;7(12): 1360-9. PMID: 15558061
  • Talley E, Sirois J, Lei Q, Bayliss D. Two-pore-Domain (KCNK) potassium channels: dynamic roles in neuronal function. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2003;9(1): 46-56. PMID: 12580339
  • Talley E, Solorzano G, Lei Q, Kim D, Bayliss D. Cns distribution of members of the two-pore-domain (KCNK) potassium channel family. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001;21(19): 7491-505. PMID: 11567039
  • Sirois J, Lei Q, Talley E, Lynch C, Bayliss D. The TASK-1 two-pore domain K+ channel is a molecular substrate for neuronal effects of inhalation anesthetics. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2000;20(17): 6347-54. PMID: 10964940
  • Talley E, Lei Q, Sirois J, Bayliss D. TASK-1, a two-pore domain K+ channel, is modulated by multiple neurotransmitters in motoneurons. Neuron. 2000;25(2): 399-410. PMID: 10719894
  • Talley E, Cribbs L, Lee J, Daud A, Perez-Reyes E, Bayliss D. Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1999;19(6): 1895-911. PMID: 10066243