Our Faculty > Douglas A. Bayliss

Douglas A. Bayliss

Douglas A. Bayliss

Education

  • BS, University of Guelph
  • MSc, University of Guelph

Primary Appointment

  • Professor, Pharmacology

Contact

Research Interest(s)

Mechanisms of Neuromodulation in Central Neurons

Research Description

Mechanisms of Neuromodulation in Central Neurons

Signaling between cells in the brain relies on electrical and chemical transmission. Ion channels traverse brain cell membranes to serve as conduits for the flow of ionic current, which creates the potential differences across the membrane that are ultimately responsible for triggering release of chemical messengers that act on nearby neurons.

Our laboratory attempts to characterize neuronal signaling in terms of identifying the molecular basis for neuronal ion channels and understanding cellular mechanisms that modulate their activity. We are particularly interested in studying those ion channels that determine intrinsic excitability of brain cells, because they are often subject to regulation by endogenous neurochemicals and since they ultimately mediate effects of many drugs, therapeutic and otherwise.

A number of technical approaches are employed in our laboratory, including chemical neuroanatomy, cellular electrophysiology in brain tissue and transfected cells, molecular biology and in vivo gene transfer. Our hope is that information combined from these different approaches will illuminate mechanisms responsible for physiological and pharmacological modulation of neuronal excitability.

Selected Publications

  • Talley E, Cribbs L, Lee J, Daud A, Perez-Reyes E, Bayliss D. Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1999;19(6): 1895-911. PMID: 10066243
  • Sirois J, Lei Q, Talley E, Lynch C, Bayliss D. The TASK-1 two-pore domain K+ channel is a molecular substrate for neuronal effects of inhalation anesthetics. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2000;20(17): 6347-54. PMID: 10964940
  • Lei Q, Jones M, Talley E, Schrier A, McIntire W, Garrison J, Bayliss D. Activation and inhibition of G protein-coupled inwardly rectifying potassium (Kir3) channels by G protein beta gamma subunits. Proceedings of the National Academy of Sciences of the United States of America. 2000;97(17): 9771-6. PMID: 10944236 | PMCID: PMC16940
  • Talley E, Solorzano G, Lei Q, Kim D, Bayliss D. Cns distribution of members of the two-pore-domain (KCNK) potassium channel family. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001;21(19): 7491-505. PMID: 11567039
  • Washburn C, Sirois J, Talley E, Guyenet P, Bayliss D. Serotonergic raphe neurons express TASK channel transcripts and a TASK-like pH- and halothane-sensitive K+ conductance. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002;22(4): 1256-65. PMID: 11850453
  • Berg A, Talley E, Manger J, Bayliss D. Motoneurons express heteromeric TWIK-related acid-sensitive K+ (TASK) channels containing TASK-1 (KCNK3) and TASK-3 (KCNK9) subunits. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004;24(30): 6693-702. PMID: 15282272
  • Chen X, Sirois J, Lei Q, Talley E, Lynch C, Bayliss D. HCN subunit-specific and cAMP-modulated effects of anesthetics on neuronal pacemaker currents. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005;25(24): 5803-14. PMID: 15958747
  • Berg A, Bayliss D. Striatal cholinergic interneurons express a receptor-insensitive homomeric TASK-3-like background K+ current. Journal of neurophysiology. 2006;97(2): 1546-52. PMID: 17167057
  • Torborg C, Berg A, Jeffries B, Bayliss D, McBain C. TASK-like conductances are present within hippocampal CA1 stratum oriens interneuron subpopulations. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006;26(28): 7362-7. PMID: 16837582
  • Chen X, Talley E, Patel N, Gomis A, McIntire W, Dong B, Viana F, Garrison J, Bayliss D. Inhibition of a background potassium channel by Gq protein alpha-subunits. Proceedings of the National Academy of Sciences of the United States of America. 2006;103(9): 3422-7. PMID: 16492788 | PMCID: PMC1413874
  • Berg A, Sen N, Bayliss D. TrpC3/C7 and Slo2.1 are molecular targets for metabotropic glutamate receptor signaling in rat striatal cholinergic interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007;27(33): 8845-56. PMID: 17699666
  • Chen X, Shu S, Kennedy D, Willcox S, Bayliss D. Subunit-specific effects of isoflurane on neuronal Ih in HCN1 knockout mice. Journal of neurophysiology. 2008;101(1): 129-40. PMID: 18971302 | PMCID: PMC2637007
  • Chekeni F, Elliott M, Sandilos J, Walk S, Kinchen J, Lazarowski E, Armstrong A, Penuela S, Laird D, Salvesen G, Isakson B, Bayliss D, Ravichandran K. Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature. 2010;467(7317): 863-7. PMID: 20944749 | PMCID: PMC3006164
  • Lazarenko R, Willcox S, Shu S, Berg A, Jevtovic-Todorovic V, Talley E, Chen X, Bayliss D. Motoneuronal TASK channels contribute to immobilizing effects of inhalational general anesthetics. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010;30(22): 7691-704. PMID: 20519544 | PMCID: PMC2909781