Dennis J. Templeton

Education

  • PhD, University of California San Diego, CA
  • MD, University of California San Diego, CA

Primary Appointment

  • Professor and Chair, Pathology

Contact

Research Interest(s)

Cell Death in Cancer Progression; Stress-Mediated Signal Transduction; Cancer Chemoprevention; Stress Inhibitors in Inflammatory Diseases

Research Description

  • Protein kinase cascades that control cell signaling and cell cycle transition

  • Mechanism of action of inflammatory cytokines in human disease processes

  • Mechanism of cancer chemoprevention agents that control signal transduction and cell death

  • Proteomic strategies to identify cancer control gene products using novel affinity labels and mass spectrometry
  • Selected Publications

    • Victor K, Rady J, Cross J, Templeton D. Proteomic profile of reversible protein oxidation using PROP, purification of reversibly oxidized proteins. PloS one. 2012;7(2): e32527. PMID: 22389707 | PMCID: PMC3289665
    • Lyons C, Victor K, Moshnikov S, Bachmann L, Baras A, Dettmann K, Cross J, Templeton D. PICquant: a quantitative platform to measure differential peptide abundance using dual-isotopic labeling with 12C6- and 13C6-phenyl isocyanate. Analytical chemistry. 2011;83(3): 856-65. PMID: 21192683 | PMCID: PMC3079250
    • Gutierrez G, Tsuji T, Cross J, Davis R, Templeton D, Jiang W, Ronai Z. JNK-mediated phosphorylation of Cdc25C regulates cell cycle entry and G(2)/M DNA damage checkpoint. The Journal of biological chemistry. 2010;285(19): 14217-28. PMID: 20220133 | PMCID: PMC2863176
    • Templeton D, Aye M, Rady J, Xu F, Cross J. Purification of reversibly oxidized proteins (PROP) reveals a redox switch controlling p38 MAP kinase activity. PloS one. 2010;5(11): e15012. PMID: 21085594 | PMCID: PMC2981573
    • Cross J, Rady J, Foss F, Lyons C, Macdonald T, Templeton D. Nutrient isothiocyanates covalently modify and inhibit the inflammatory cytokine macrophage migration inhibitory factor (MIF). The Biochemical journal. 2009;423(3): 315-21. PMID: 19723024 | PMCID: PMC2858637
    • Victor K, Murgai M, Lyons C, Templeton T, Moshnikov S, Templeton D. MAZIE: a mass and charge inference engine to enhance database searching of tandem mass spectra. Journal of the American Society for Mass Spectrometry. 2009;21(1): 80-7. PMID: 19850495 | PMCID: PMC2818324
    • Zhao Y, Lyons C, Xiao A, Templeton D, Sang Q, Brew K, Hussaini I. Urokinase directly activates matrix metalloproteinases-9: a potential role in glioblastoma invasion. Biochemical and biophysical research communications. 2008;369(4): 1215-20. PMID: 18355442 | PMCID: PMC2562868
    • Cross J, Foss F, Rady J, Macdonald T, Templeton D. The isothiocyanate class of bioactive nutrients covalently inhibit the MEKK1 protein kinase. BMC cancer. 2007;7 183. PMID: 17894894 | PMCID: PMC2071920
    • Cross J, Templeton D. Regulation of signal transduction through protein cysteine oxidation. Antioxidants & redox signaling. 2006;8(9): 1819-27. PMID: 16987034