David S. Cafiso


  • AB, University of California, Berkeley, CA
  • PhD, University of California, Berkeley, CA
  • Postdoc, University of California, Berkeley, CA
  • Postdoc, Stanford University, Stanford, CA

Primary Appointment

  • Professor, Chemistry


Research Interest(s)

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Research Description

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Selected Publications

  • Identifying and Quantitating Conformational Exchange in Membrane Proteins Using Site-Directed Spin Labeling. Accounts of chemical research. 2014. PMID: 25152957
  • Liang B, Dawidowski D, Ellena J, Tamm L, Cafiso D. The SNARE motif of synaptobrevin exhibits an aqueous-interfacial partitioning that is modulated by membrane curvature. Biochemistry. 2014;53(9): 1485-94. PMID: 24552121 | PMCID: PMC3985803
  • Lu B, Kiessling V, Tamm L, Cafiso D. The juxtamembrane linker of full-length synaptotagmin 1 controls oligomerization and calcium-dependent membrane binding. The Journal of biological chemistry. 2014;289(32): 22161-71. PMID: 24973220 | PMCID: PMC4139229
  • Dawidowski D, Cafiso D. Allosteric control of syntaxin 1a by Munc18-1: characterization of the open and closed conformations of syntaxin. Biophysical journal. 2013;104(7): 1585-94. PMID: 23561535 | PMCID: PMC3617443
  • Freed D, Lukasik S, Sikora A, Mokdad A, Cafiso D. Monomeric TonB and the Ton box are required for the formation of a high-affinity transporter-TonB complex. Biochemistry. 2013;52(15): 2638-48. PMID: 23517233 | PMCID: PMC3630801
  • Regan M, Horanyi P, Pryor E, Sarver J, Cafiso D, Bushweller J. Structural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibited. Proceedings of the National Academy of Sciences of the United States of America. 2013;110(33): 13374-9. PMID: 23898196 | PMCID: PMC3746864
  • Flores Jiménez R, Cafiso D. The N-terminal domain of a TonB-dependent transporter undergoes a reversible stepwise denaturation. Biochemistry. 2012;51(17): 3642-50. PMID: 22497281 | PMCID: PMC3362919
  • Mokdad A, Herrick D, Kahn A, Andrews E, Kim M, Cafiso D. Ligand-Induced Structural Changes in the Escherichia coli Ferric Citrate Transporter Reveal Modes for Regulating Protein-Protein Interactions. Journal of molecular biology. 2012;423(5): 818-30. PMID: 22982293 | PMCID: PMC3472153
  • Ellena J, Lackowicz P, Mongomery H, Cafiso D. Membrane thickness varies around the circumference of the transmembrane protein BtuB. Biophysical journal. 2011;100(5): 1280-7. PMID: 21354401 | PMCID: PMC3043205
  • Freed D, Khan A, Horanyi P, Cafiso D. Molecular origin of electron paramagnetic resonance line shapes on β-barrel membrane proteins: the local solvation environment modulates spin-label configuration. Biochemistry. 2011;50(41): 8792-803. PMID: 21894979 | PMCID: PMC3199607
  • Jiménez R, Freed D, Cafiso D. Lipid and membrane mimetic environments modulate spin label side chain configuration in the outer membrane protein A. The journal of physical chemistry. B. 2011;115(49): 14822-30. PMID: 22034842 | PMCID: PMC3237940
  • Kuo W, Herrick D, Cafiso D. Phosphatidylinositol 4,5-bisphosphate alters synaptotagmin 1 membrane docking and drives opposing bilayers closer together. Biochemistry. 2011;50(13): 2633-41. PMID: 21344950 | PMCID: PMC3071796
  • Lai A, Tamm L, Ellena J, Cafiso D. Synaptotagmin 1 modulates lipid acyl chain order in lipid bilayers by demixing phosphatidylserine. The Journal of biological chemistry. 2011;286(28): 25291-300. PMID: 21610074 | PMCID: PMC3137100
  • Wan C, Kiessling V, Cafiso D, Tamm L. Partitioning of synaptotagmin I C2 domains between liquid-ordered and liquid-disordered inner leaflet lipid phases. Biochemistry. 2011;50(13): 2478-85. PMID: 21322640 | PMCID: PMC3094915
  • Freed D, Horanyi P, Wiener M, Cafiso D. Conformational exchange in a membrane transport protein is altered in protein crystals. Biophysical journal. 2010;99(5): 1604-10. PMID: 20816073 | PMCID: PMC2931748
  • Ellena J, Liang B, Wiktor M, Stein A, Cafiso D, Jahn R, Tamm L. Dynamic structure of lipid-bound synaptobrevin suggests a nucleation-propagation mechanism for trans-SNARE complex formation. Proceedings of the National Academy of Sciences of the United States of America. 2009;106(48): 20306-11. PMID: 19918058 | PMCID: PMC2787132
  • Herrick D, Kuo W, Huang H, Schwieters C, Ellena J, Cafiso D. Solution and membrane-bound conformations of the tandem C2A and C2B domains of synaptotagmin 1: Evidence for bilayer bridging. Journal of molecular biology. 2009;390(5): 913-23. PMID: 19501597 | PMCID: PMC2763419
  • Kuo W, Herrick D, Ellena J, Cafiso D. The calcium-dependent and calcium-independent membrane binding of synaptotagmin 1: two modes of C2B binding. Journal of molecular biology. 2009;387(2): 284-94. PMID: 19302798 | PMCID: PMC2669496
  • Huang H, Cafiso D. Conformation and membrane position of the region linking the two C2 domains in synaptotagmin 1 by site-directed spin labeling. Biochemistry. 2008;47(47): 12380-8. PMID: 18956883 | PMCID: PMC2661311
  • Zhou Y, Cierpicki T, Jimenez R, Lukasik S, Ellena J, Cafiso D, Kadokura H, Beckwith J, Bushweller J. NMR solution structure of the integral membrane enzyme DsbB: functional insights into DsbB-catalyzed disulfide bond formation. Molecular cell. 2008;31(6): 896-908. PMID: 18922471 | PMCID: PMC2622435
  • Derewenda U, Tarricone C, Choi W, Cooper D, Lukasik S, Perrina F, Tripathy A, Kim M, Cafiso D, Musacchio A, Derewenda Z. The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly. Structure (London, England : 1993). 2007;15(11): 1467-81. PMID: 17997972
  • Kim M, Xu Q, Murray D, Cafiso D. Solutes alter the conformation of the ligand binding loops in outer membrane transporters. Biochemistry. 2007;47(2): 670-9. PMID: 18092811
  • Liao H, Ellena J, Liu L, Szabo G, Cafiso D, Castle D. Secretory carrier membrane protein SCAMP2 and phosphatidylinositol 4,5-bisphosphate interactions in the regulation of dense core vesicle exocytosis. Biochemistry. 2007;46(38): 10909-20. PMID: 17713930
  • Herrick D, Sterbling S, Rasch K, Hinderliter A, Cafiso D. Position of synaptotagmin I at the membrane interface: cooperative interactions of tandem C2 domains. Biochemistry. 2006;45(32): 9668-74. PMID: 16893168