David Parichy


  • BA, Reed College
  • PhD, University of California, Davis
  • Postdoc, University of Virginia

Primary Appointment

  • Pratt-Ivy Foundation Distinguished Professor of Morphogenesis, Biology


Research Interest(s)

Developmental Genetics, Evolution and Regeneration of Adult Morphology in Vertebrates

Research Description

Much of our work uses zebrafish and related species, and emphasizes pigmentation, pigment cells, and their neural crest progenitors. Additional efforts focus on mechanisms of melanoma progression, development and regeneration of scales and skin in zebrafish, and appendage regeneration in salamanders.

Past areas of research have included genetic controls of post-embryonic development and metamorphosis; behavioral significance of pigment pattern variation; molecular and endocrine factors in skeletogenesis and kidney function; zebrafish natural history in India; and pigment pattern development and evolution in amphibians. The lab has diverse interests and we are always happy to entertain new ideas. We welcome postdoctoral scholars, graduate students and undergraduates.

Selected Publications

  • Eom D, Parichy D. A macrophage relay for long-distance signaling during postembryonic tissue remodeling. Science (New York, N.Y.). 2017;355(6331): 1317-1320. PMID: 28209639
  • Eom D, Bain E, Patterson L, Grout M, Parichy D. Long-distance communication by specialized cellular projections during pigment pattern development and evolution. eLife. 2015;4. PMID: 26701906 | PMCID: PMC4764569
  • McMenamin S, Bain E, McCann A, Patterson L, Eom D, Waller Z, Hamill J, Kuhlman J, Eisen J, Parichy D. Thyroid hormone-dependent adult pigment cell lineage and pattern in zebrafish. Science (New York, N.Y.). 2014;345(6202): 1358-61. PMID: 25170046 | PMCID: PMC4211621
  • Patterson L, Bain E, Parichy D. Pigment cell interactions and differential xanthophore recruitment underlying zebrafish stripe reiteration and Danio pattern evolution. Nature communications. 2014;5 5299. PMID: 25374113 | PMCID: PMC4224114
  • Patterson L, Parichy D. Interactions with iridophores and the tissue environment required for patterning melanophores and xanthophores during zebrafish adult pigment stripe formation. PLoS genetics. 2013;9(5): e1003561. PMID: 23737760 | PMCID: PMC3667786
  • Budi E, Patterson L, Parichy D. Post-embryonic nerve-associated precursors to adult pigment cells: genetic requirements and dynamics of morphogenesis and differentiation. PLoS genetics. 2011;7(5): e1002044. PMID: 21625562 | PMCID: PMC3098192
  • Parichy D, Elizondo M, Mills M, Gordon T, Engeszer R. Normal table of postembryonic zebrafish development: staging by externally visible anatomy of the living fish. Developmental dynamics : an official publication of the American Association of Anatomists. 2009;238(12): 2975-3015. PMID: 19891001 | PMCID: PMC3030279
  • Budi E, Patterson L, Parichy D. Embryonic requirements for ErbB signaling in neural crest development and adult pigment pattern formation. Development (Cambridge, England). 2008;135(15): 2603-14. PMID: 18508863 | PMCID: PMC2704560
  • Engeszer R, Wang G, Ryan M, Parichy D. Sex-specific perceptual spaces for a vertebrate basal social aggregative behavior. Proceedings of the National Academy of Sciences of the United States of America. 2008;105(3): 929-33. PMID: 18199839 | PMCID: PMC2242707
  • Engeszer R, Patterson L, Rao A, Parichy D. Zebrafish in the wild: a review of natural history and new notes from the field. Zebrafish. 2007;4(1): 21-40. PMID: 18041940
  • Mills M, Nuckels R, Parichy D. Deconstructing evolution of adult phenotypes: genetic analyses of kit reveal homology and evolutionary novelty during adult pigment pattern development of Danio fishes. Development (Cambridge, England). 2007;134(6): 1081-90. PMID: 17287252
  • Engeszer R, Ryan M, Parichy D. Learned social preference in zebrafish. Current biology : CB. 2004;14(10): 881-4. PMID: 15186744
  • Quigley I, Turner J, Nuckels R, Manuel J, Budi E, MacDonald E, Parichy D. Pigment pattern evolution by differential deployment of neural crest and post-embryonic melanophore lineages in Danio fishes. Development (Cambridge, England). 2004;131(24): 6053-69. PMID: 15537688
  • Parichy D, Turner J. Temporal and cellular requirements for Fms signaling during zebrafish adult pigment pattern development. Development (Cambridge, England). 2003;130(5): 817-33. PMID: 12538511