David L. Brautigan


  • BA, Kalamazoo College, Kalamazoo, MI
  • MS, Northwestern University, Evanston, IL
  • PhD, Northwestern University, Evanston, IL
  • Postdoc, University of Washington School of Medicine, Seattle, WA

Primary Appointment

  • Professor, Microbiology, Immunology, and Cancer Biology


Research Interest(s)

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Research Description

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Selected Publications

  • Yan C, Liu D, Li L, Wempe M, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski C, Nitz M, Knabe E, Brautigan D, Paschal B, Schwartz M, Jones D, Ross D, Meroueh S, Theodorescu D. Discovery and characterization of small molecules that target the GTPase Ral. Nature. 2014. PMID: 25219851 | PMCID: PMC4351747
  • Dziegielewska B, Brautigan D, Larner J, Dziegielewski J. T-type Ca2+ Channel Inhibition Induces p53 Dependent Cell Growth Arrest and Apoptosis through Activation of p38-MAPK in Colon Cancer Cells. Molecular cancer research : MCR. 2013. PMID: 24362252
  • Wang L, Brautigan D. α-SNAP inhibits AMPK signaling to reduce mitochondrial biogenesis and dephosphorylates Thr172 in AMPKα in vitro. Nature communications. 2013;4 1559. PMID: 23463002 | PMCID: PMC3595137
  • Protein Ser/ Thr phosphatases - the ugly ducklings of cell signalling. The FEBS journal. 2012. PMID: 22519956
  • Hosing A, Valerie N, Dziegielewski J, Brautigan D, Larner J. PP6 regulatory subunit R1 is bidentate anchor for targeting protein phosphatase-6 to DNA-dependent protein kinase. The Journal of biological chemistry. 2012;287(12): 9230-9. PMID: 22298787 | PMCID: PMC3308816
  • Edelson J, Brautigan D. The Discodermia calyx Toxin Calyculin A Enhances Cyclin D1 Phosphorylation and Degradation, and Arrests Cell Cycle Progression in Human Breast Cancer Cells. Toxins. 2011;3(1): 105-19. PMID: 22069692 | PMCID: PMC3210456
  • Hall E, Gurel V, Dahlberg A, McMichael J, Brautigan D. Inhibition of human breast cancer Matrigel invasion by Streptolysin O activation of the EGF receptor ErbB1. Cellular signalling. 2011;23(12): 1972-7. PMID: 21787862 | PMCID: NIHMS312507
  • Martin-Montalvo A, Gonzalez-Mariscal I, Padilla S, Ballesteros M, Brautigan D, Navas P, Santos-Ocaña C. Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p. The Biochemical journal. 2011. PMID: 21812761
  • Molhoek K, Erdag G, Rasamny J, Murphy C, Deacon D, Patterson J, Slingluff C, Brautigan D. VEGFR-2 expression in human melanoma: revised assessment. International journal of cancer. Journal international du cancer. 2011;129(12): 2807-15. PMID: 21544800 | PMCID: PMC3205910
  • Molhoek K, Shada A, Smolkin M, Chowbina S, Papin J, Brautigan D, Slingluff C. Comprehensive analysis of receptor tyrosine kinase activation in human melanomas reveals autocrine signaling through IGF-1R. Melanoma research. 2011;21(4): 274-84. PMID: 21654344 | PMCID: PMC3131461
  • Hall E, Balsbaugh J, Rose K, Shabanowitz J, Hunt D, Brautigan D. Comprehensive analysis of phosphorylation sites in Tensin1 reveals regulation by p38MAPK. Molecular & cellular proteomics : MCP. 2010;9(12): 2853-63. PMID: 20798394 | PMCID: PMC3101865
  • Hans S, Camara F, Altiti A, Martín-Montalvo A, Brautigan D, Heimark D, Larner J, Grindrod S, Brown M, Mootoo D. Synthesis of C-glycoside analogues of beta-galactosamine-(1-->4)-3-O-methyl-D-chiro-inositol and assay as activator of protein phosphatases PDHP and PP2Calpha. Bioorganic & medicinal chemistry. 2010;18(3): 1103-10. PMID: 20079654 | PMCID: PMC3408221
  • Larner J, Brautigan D, Thorner M. D-chiro-inositol glycans in insulin signaling and insulin resistance. Molecular medicine (Cambridge, Mass.). 2010;16(11): 543-52. PMID: 20811656 | PMCID: PMC2972396
  • Ohama T, Brautigan D. Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A. The Journal of biological chemistry. 2010;285(12): 8711-8. PMID: 20100830 | PMCID: PMC2838294
  • Wang H, Owens C, Chandra N, Conaway M, Brautigan D, Theodorescu D. Phosphorylation of RalB is important for bladder cancer cell growth and metastasis. Cancer research. 2010;70(21): 8760-9. PMID: 20940393 | PMCID: PMC3025490
  • Broglie P, Matsumoto K, Akira S, Brautigan D, Ninomiya-Tsuji J. Transforming growth factor beta-activated kinase 1 (TAK1) kinase adaptor, TAK1-binding protein 2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in tumor necrosis factor signaling pathway. The Journal of biological chemistry. 2009;285(4): 2333-9. PMID: 19955178 | PMCID: PMC2807291
  • Guergnon J, Derewenda U, Edelson J, Brautigan D. Mapping of protein phosphatase-6 association with its SAPS domain regulatory subunit using a model of helical repeats. BMC biochemistry. 2009;10 24. PMID: 19835610 | PMCID: PMC2765987
  • Hall E, Daugherty A, Choi C, Horwitz A, Brautigan D. Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion. The Journal of biological chemistry. 2009;284(50): 34713-22. PMID: 19826001 | PMCID: PMC2787334
  • Mi J, Bolesta E, Brautigan D, Larner J. PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53. Molecular cancer therapeutics. 2009;8(1): 135-40. PMID: 19139122
  • Mi J, Dziegielewski J, Bolesta E, Brautigan D, Larner J. Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6. PloS one. 2009;4(2): e4395. PMID: 19198648 | PMCID: PMC2634843
  • Fuller B, Lampson M, Foley E, Rosasco-Nitcher S, Le K, Tobelmann P, Brautigan D, Stukenberg P, Kapoor T. Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient. Nature. 2008;453(7198): 1132-6. PMID: 18463638 | PMCID: PMC2724008
  • Molhoek K, Griesemann H, Shu J, Gershenwald J, Brautigan D, Slingluff C. Human melanoma cytolysis by combined inhibition of mammalian target of rapamycin and vascular endothelial growth factor/vascular endothelial growth factor receptor-2. Cancer research. 2008;68(11): 4392-7. PMID: 18519701 | PMCID: PMC2727753
  • Molhoek K, McSkimming C, Olson W, Brautigan D, Slingluff C. Apoptosis of CD4(+)CD25(high) T cells in response to Sirolimus requires activation of T cell receptor and is modulated by IL-2. Cancer immunology, immunotherapy : CII. 2008;58(6): 867-76. PMID: 18841360 | PMCID: PMC2688807
  • Ohama T, Okada M, Murata T, Brautigan D, Hori M, Ozaki H. Sphingosine-1-phosphate enhances IL-1{beta}-induced COX-2 expression in mouse intestinal subepithelial myofibroblasts. American journal of physiology. Gastrointestinal and liver physiology. 2008;295(4): G766-75. PMID: 18703638
  • Prickett T, Ninomiya-Tsuji J, Broglie P, Muratore-Schroeder T, Shabanowitz J, Hunt D, Brautigan D. TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappaB. The Journal of biological chemistry. 2008;283(28): 19245-54. PMID: 18456659 | PMCID: PMC2443674
  • Stefansson B, Ohama T, Daugherty A, Brautigan D. Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. Biochemistry. 2008;47(5): 1442-51. PMID: 18186651
  • Wang W, Brautigan D. Phosphatase inhibitor 2 promotes acetylation of tubulin in the primary cilium of human retinal epithelial cells. BMC cell biology. 2008;9 62. PMID: 19036150 | PMCID: PMC2630314
  • Wang W, Cronmiller C, Brautigan D. Maternal phosphatase inhibitor-2 is required for proper chromosome segregation and mitotic synchrony during Drosophila embryogenesis. Genetics. 2008;179(4): 1823-33. PMID: 18689877 | PMCID: PMC2516061
  • Wang W, Stukenberg P, Brautigan D. Phosphatase inhibitor-2 balances protein phosphatase 1 and aurora B kinase for chromosome segregation and cytokinesis in human retinal epithelial cells. Molecular biology of the cell. 2008;19(11): 4852-62. PMID: 18716057 | PMCID: PMC2575180
  • Yoo S, Jimenez R, Sanders J, Boylan J, Brautigan D, Gruppuso P. The alpha4-containing form of protein phosphatase 2A in liver and hepatic cells. Journal of cellular biochemistry. 2008;105(1): 290-300. PMID: 18543252 | PMCID: PMC2597445