David F Kashatus

Education

  • AB, Princeton University
  • PhD, University of North Carolina

Primary Appointment

  • Assistant Professor, Microbiology, Immunology, and Cancer Biology

Contact

Research Interest(s)

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Research Description

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Selected Publications

  • Kashatus J, Nascimento A, Myers L, Sher A, Byrne F, Hoehn K, Counter C, Kashatus D. Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth. Molecular cell. 2015;57(3): 537-551. PMID: 25658205 | PMCID: PMC4393013
  • Xie Q, Wu Q, Horbinski C, Flavahan W, Yang K, Zhou W, Dombrowski S, Huang Z, Fang X, Shi Y, Ferguson A, Kashatus D, Bao S, Rich J. Mitochondrial control by DRP1 in brain tumor initiating cells. Nature neuroscience. 2015;18(4): 501-10. PMID: 25730670 | PMCID: PMC4376639
  • An in vitro system to evaluate the scaffold function of the RalA effector protein RalBP1. Methods in molecular biology (Clifton, N.J.). 2014;1120 207-16. PMID: 24470028
  • Ral GTPases in tumorigenesis: emerging from the shadows. Experimental cell research. 2013;319(15): 2337-42. PMID: 23830877
  • Kashatus D, Counter C. Breaking up is hard to do: RalA, mitochondrial fission and cancer. Small GTPases. 2012;2(6): 329-333. PMID: 22545232 | PMCID: PMC3337163
  • Lampson B, Kendall S, Ancrile B, Morrison M, Shealy M, Barrientos K, Crowe M, Kashatus D, White R, Gurley S, Cardona D, Counter C. Targeting eNOS in pancreatic cancer. Cancer research. 2012;72(17): 4472-82. PMID: 22738914 | PMCID: PMC3749841
  • Kashatus D, Lim K, Brady D, Pershing N, Cox A, Counter C. RALA and RALBP1 regulate mitochondrial fission at mitosis. Nature cell biology. 2011;13(9): 1108-15. PMID: 21822277 | PMCID: PMC3167028
  • Vignola M, Kashatus D, Taylor G, Counter C, Valdivia R. cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis. The Journal of biological chemistry. 2010;285(28): 21625-35. PMID: 20452986 | PMCID: PMC2898388
  • Zipfel P, Brady D, Kashatus D, Ancrile B, Tyler D, Counter C. Ral activation promotes melanomagenesis. Oncogene. 2010;29(34): 4859-64. PMID: 20562921 | PMCID: PMC2928877
  • Lim K, Brady D, Kashatus D, Ancrile B, Der C, Cox A, Counter C. Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. Molecular and cellular biology. 2009;30(2): 508-23. PMID: 19901077 | PMCID: PMC2798468
  • Lim K, Ancrile B, Kashatus D, Counter C. Tumour maintenance is mediated by eNOS. Nature. 2008;452(7187): 646-9. PMID: 18344980 | PMCID: PMC2688829
  • O'Neil B, Bůzková P, Farrah H, Kashatus D, Sanoff H, Goldberg R, Baldwin A, Funkhouser W. Expression of nuclear factor-kappaB family proteins in hepatocellular carcinomas. Oncology. 2007;72(1): 97-104. PMID: 18025803
  • Kashatus D, Cogswell P, Baldwin A. Expression of the Bcl-3 proto-oncogene suppresses p53 activation. Genes & development. 2005;20(2): 225-35. PMID: 16384933 | PMCID: PMC1356113
  • Hanson J, Hawke N, Kashatus D, Baldwin A. The nuclear factor kappaB subunits RelA/p65 and c-Rel potentiate but are not required for Ras-induced cellular transformation. Cancer research. 2004;64(20): 7248-55. PMID: 15492243
  • Cogswell P, Kashatus D, Keifer J, Guttridge D, Reuther J, Bristow C, Roy S, Nicholson D, Baldwin A. NF-kappa B and I kappa B alpha are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-kappa B. The Journal of biological chemistry. 2002;278(5): 2963-8. PMID: 12433922
  • Reuther-Madrid J, Kashatus D, Chen S, Li X, Westwick J, Davis R, Earp H, Wang C, Baldwin Jr A. The p65/RelA subunit of NF-kappaB suppresses the sustained, antiapoptotic activity of Jun kinase induced by tumor necrosis factor. Molecular and cellular biology. 2002;22(23): 8175-83. PMID: 12417721 | PMCID: PMC134075