Daniel Gioeli


  • PhD, University of North Carolina

Primary Appointment

  • Associate Professor, Microbiology, Immunology, and Cancer Biology


Research Interest(s)

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Research Description

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Selected Publications

  • Axelrod M, Gordon V, Mendez R, Leimgruber S, Conaway M, Sharlow E, Jameson M, Gioeli D, Weber M. p70S6 kinase is a critical node that integrates HER-family and PI3 kinase signaling networks. Cellular signalling. 2014. PMID: 24662264 | PMCID: PMC4091927
  • Axelrod M, Gordon V, Conaway M, Tarcsafalvi A, Neitzke D, Gioeli D, Weber M. Combinatorial drug screening identifies compensatory pathway interactions and adaptive resistance mechanisms. Oncotarget. 2013;4(4): 622-35. PMID: 23599172 | PMCID: PMC3720609
  • Roller D, Axelrod M, Capaldo B, Jensen K, Mackey A, Weber M, Gioeli D. Synthetic lethal screening with small molecule inhibitors provides a pathway to rational combination therapies for melanoma. Molecular cancer therapeutics. 2012. PMID: 22962324 | PMCID: NIHMS405900
  • Whitworth H, Bhadel S, Ivey M, Conaway M, Spencer A, Hernan R, Holemon H, Gioeli D. Identification of kinases regulating prostate cancer cell growth using an RNAi phenotypic screen. PloS one. 2012;7(6): e38950. PMID: 22761715 | PMCID: PMC3384611
  • Gioeli D, Wunderlich W, Sebolt-Leopold J, Bekiranov S, Wulfkuhle J, Petricoin E, Conaway M, Weber M. Compensatory pathways induced by MEK inhibition are effective drug targets for combination therapy against castration-resistant prostate cancer. Molecular cancer therapeutics. 2011;10(9): 1581-90. PMID: 21712477 | PMCID: PMC3315368
  • Gordon V, Bhadel S, Wunderlich W, Zhang J, Ficarro S, Mollah S, Shabanowitz J, Hunt D, Xenarios I, Hahn W, Conaway M, Carey M, Gioeli D. CDK9 regulates AR promoter selectivity and cell growth through serine 81 phosphorylation. Molecular endocrinology (Baltimore, Md.). 2010;24(12): 2267-80. PMID: 20980437 | PMCID: PMC2999477
  • Kelley J, Talley A, Spencer A, Gioeli D, Paschal B. Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors. BMC cell biology. 2010;11 63. PMID: 20701745 | PMCID: PMC2929220
  • Ni L, Yang C, Gioeli D, Frierson H, Toft D, Paschal B. FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells. Molecular and cellular biology. 2010;30(5): 1243-53. PMID: 20048054 | PMCID: PMC2820886
  • Tilghman R, Cowan C, Mih J, Koryakina Y, Gioeli D, Slack-Davis J, Blackman B, Tschumperlin D, Parsons J. Matrix rigidity regulates cancer cell growth and cellular phenotype. PloS one. 2010;5(9): e12905. PMID: 20886123 | PMCID: PMC2944843
  • DaSilva J, Gioeli D, Weber M, Parsons S. The neuroendocrine-derived peptide parathyroid hormone-related protein promotes prostate cancer cell growth by stabilizing the androgen receptor. Cancer research. 2009;69(18): 7402-11. PMID: 19706771 | PMCID: PMC2803023
  • Wu Z, Gioeli D, Conaway M, Weber M, Theodorescu D. Restoration of PTEN expression alters the sensitivity of prostate cancer cells to EGFR inhibitors. The Prostate. 2008;68(9): 935-44. PMID: 18386291 | PMCID: PMC2748221
  • Bigler D, Gioeli D, Conaway M, Weber M, Theodorescu D. Rap2 regulates androgen sensitivity in human prostate cancer cells. The Prostate. 2007;67(14): 1590-9. PMID: 17918750
  • Kesler C, Gioeli D, Conaway M, Weber M, Paschal B. Subcellular localization modulates activation function 1 domain phosphorylation in the androgen receptor. Molecular endocrinology (Baltimore, Md.). 2007;21(9): 2071-84. PMID: 17579212
  • Wu Z, Conaway M, Gioeli D, Weber M, Theodorescu D. Conditional expression of PTEN alters the androgen responsiveness of prostate cancer cells. The Prostate. 2006;66(10): 1114-23. PMID: 16637073
  • Gioeli D, Black B, Gordon V, Spencer A, Kesler C, Eblen S, Paschal B, Weber M. Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization. Molecular endocrinology (Baltimore, Md.). 2005;20(3): 503-15. PMID: 16282370
  • Bakin R, Gioeli D, Bissonette E, Weber M. Attenuation of Ras signaling restores androgen sensitivity to hormone-refractory C4-2 prostate cancer cells. Cancer research. 2003;63(8): 1975-80. PMID: 12702591
  • Gioeli D, Ficarro S, Kwiek J, Aaronson D, Hancock M, Catling A, White F, Christian R, Settlage R, Shabanowitz J, Hunt D, Weber M. Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites. The Journal of biological chemistry. 2002;277(32): 29304-14. PMID: 12015328