Daniel A. Engel


  • PhD, Yale University

Primary Appointment

  • Professor, Microbiology, Immunology, and Cancer Biology


Research Interest(s)

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Research Description

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Selected Publications

  • DziubaƄska P, Derewenda U, Ellena J, Engel D, Derewenda Z. The structure of the C-terminal domain of the Zaire ebolavirus nucleoprotein. Acta crystallographica. Section D, Biological crystallography. 2014;70 2420-9. PMID: 25195755 | PMCID: PMC4157450
  • The influenza virus NS1 protein as a therapeutic target. Antiviral research. 2013;99(3): 409-416. PMID: 23796981
  • Suomalainen M, Luisoni S, Boucke K, Bianchi S, Engel D, Greber U. A direct and versatile assay measuring membrane penetration of adenovirus in single cells. Journal of virology. 2013. PMID: 24027314 | PMCID: PMC3807902
  • Gupta A, Jha S, Engel D, Ornelles D, Dutta A. Tip60 degradation by adenovirus relieves transcriptional repression of viral transcriptional activator EIA. Oncogene. 2012. PMID: 23178490 | PMCID: PMC3955737
  • Frieman M, Basu D, Matthews K, Taylor J, Jones G, Pickles R, Baric R, Engel D. Yeast based small molecule screen for inhibitors of SARS-CoV. PloS one. 2011;6(12): e28479. PMID: 22164298 | PMCID: PMC3229576
  • Jablonski J, Basu D, Engel D, Geysen H. Design, synthesis, and evaluation of novel small molecule inhibitors of the influenza virus protein NS1. Bioorganic & medicinal chemistry. 2011;20(1): 487-97. PMID: 22099257 | PMCID: NIHMS333169
  • Walkiewicz M, Basu D, Jablonski J, Geysen H, Engel D. Novel inhibitor of influenza non-structural protein 1 blocks multi-cycle replication in an RNase L-dependent manner. The Journal of general virology. 2010;92 60-70. PMID: 20881091 | PMCID: PMC3052532
  • Walkiewicz M, Morral N, Engel D. Accurate single-day titration of adenovirus vectors based on equivalence of protein VII nuclear dots and infectious particles. Journal of virological methods. 2009;159(2): 251-8. PMID: 19406166 | PMCID: PMC2774845
  • Basu D, Walkiewicz M, Frieman M, Baric R, Auble D, Engel D. Novel influenza virus NS1 antagonists block replication and restore innate immune function. Journal of virology. 2008;83(4): 1881-91. PMID: 19052087 | PMCID: PMC2643796
  • Johnson J, Osheim Y, Xue Y, Emanuel M, Lewis P, Bankovich A, Beyer A, Engel D. Adenovirus protein VII condenses DNA, represses transcription, and associates with transcriptional activator E1A. Journal of virology. 2004;78(12): 6459-68. PMID: 15163739 | PMCID: PMC416553