Christopher A. Moskaluk

Education

  • BS, University of Illinois, Champaign-Urbana, IL
  • PhD, Duke University, Durham, NC
  • MD, Duke University, Durham, NC
  • Medical Residency, National Institutes of Health, Bethesda, MD
  • Fellowship, Johns Hopkins University, Baltimore, MD

Primary Appointment

  • Professor and Chair, Pathology

Contact

Research Interest(s)

Molecular pathogenesis and genomic analysis of human cancers

Research Description

Genomic analysis of primary human cancer specimens for global genetic and gene expression alterations. Development of model systems to validate biological roles of candidate genes. Translation of experimental findings to diagnostic clinical tests and/or therapeutic interventions.

Selected Publications

  • Jones D, Moskaluk C, Gillenwater H, Petroni G, Burks S, Philips J, Rehm P, Olazagasti J, Kozower B, Bao Y. Phase I trial of induction histone deacetylase and proteasome inhibition followed by surgery in non-small-cell lung cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2012;7(11): 1683-90. PMID: 23059775 | PMCID: PMC3473142
  • Rasamny J, Allak A, Krook K, Jo V, Policarpio-Nicolas M, Sumner H, Moskaluk C, Frierson H, Jameson M. Cyclin D1 and FADD as biomarkers in head and neck squamous cell carcinoma. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2012;146(6): 923-31. PMID: 22323434
  • Williams P, Owens C, Dziegielewski J, Moskaluk C, Read P, Larner J, Story M, Brock W, Amundson S, Lee J, Theodorescu D. Cyclophilin B expression is associated with in vitro radioresistance and clinical outcome after radiotherapy. Neoplasia (New York, N.Y.). 2012;13(12): 1122-31. PMID: 22241958 | PMCID: PMC3257187
  • Bakhru M, Foley P, Gatesman J, Schmitt T, Moskaluk C, Kahaleh M. Fully covered self-expanding metal stents placed temporarily in the bile duct: safety profile and histologic classification in a porcine model. BMC gastroenterology. 2011;11 76. PMID: 21689439 | PMCID: PMC3142530
  • Brill L, Kanner W, Fehr A, Andrén Y, Moskaluk C, Löning T, Stenman G, Frierson H. Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2011;24(9): 1169-76. PMID: 21572406
  • Moskaluk C, Baras A, Mancuso S, Fan H, Davidson R, Dirks D, Golden W, Frierson H. Development and characterization of xenograft model systems for adenoid cystic carcinoma. Laboratory investigation; a journal of technical methods and pathology. 2011;91(10): 1480-90. PMID: 21709671
  • Pasic L, Eisinger-Mathason T, Velayudhan B, Moskaluk C, Brenin D, Macara I, Lannigan D. Sustained activation of the HER1-ERK1/2-RSK signaling pathway controls myoepithelial cell fate in human mammary tissue. Genes & development. 2011;25(15): 1641-53. PMID: 21828273 | PMCID: PMC3182019
  • Sun D, Lee Y, Malhotra A, Kim H, Matecic M, Evans C, Jensen R, Moskaluk C, Dutta A. miR-99 family of MicroRNAs suppresses the expression of prostate-specific antigen and prostate cancer cell proliferation. Cancer research. 2011;71(4): 1313-24. PMID: 21212412 | PMCID: PMC3523179
  • Mobasheri A, Moskaluk C, Marples D, Shakibaei M. Expression of aquaporin 1 (AQP1) in human synovitis. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2010;192(2): 116-21. PMID: 20149606
  • Shoushtari A, Meeneghan M, Sheng K, Moskaluk C, Thomas C, Reibel J, Levine P, Jameson M, Keene K, Read P. Intensity-modulated radiotherapy outcomes for oropharyngeal squamous cell carcinoma patients stratified by p16 status. Cancer. 2010;116(11): 2645-54. PMID: 20225325
  • Stelow E, Shami V, Moskaluk C, Burns K, Legallo R, Jones D. Esophageal inflammatory myofibroblastic tumor sampled by EUS-FNA. Gastrointestinal endoscopy. 2010;72(1): 209-10. PMID: 20226450
  • Unger K, Romney D, Koc M, Moskaluk C, Friel C, Foley E, Rich T. Preoperative chemoradiation for rectal cancer using capecitabine and celecoxib correlated with posttreatment assessment of thymidylate synthase and thymidine phosphorylase expression. International journal of radiation oncology, biology, physics. 2010;80(5): 1377-82. PMID: 20656421
  • Baisden J, Kahaleh M, Weiss G, Sanfey H, Moskaluk C, Yeaton P, de Lange E, Rich T. Multimodality Treatment With Helical Tomotherapy Intensity Modulated Radiotherapy, Capecitabine, and Photodynamic Therapy is Feasible and Well Tolerated in Patients With Hilar Cholangiocarcinoma. Gastrointestinal cancer research : GCR. 2009;2(5): 219-24. PMID: 19259306 | PMCID: PMC2632558
  • Baras A, Yu Y, Filtz M, Kim B, Moskaluk C. Combined genomic and gene expression microarray profiling identifies ECOP as an upregulated gene in squamous cell carcinomas independent of DNA amplification. Oncogene. 2009;28(32): 2919-24. PMID: 19525979
  • Bellizzi A, Woodford R, Moskaluk C, Jones D, Kozower B, Stelow E. Basaloid squamous cell carcinoma of the esophagus: assessment for high-risk human papillomavirus and related molecular markers. The American journal of surgical pathology. 2009;33(11): 1608-14. PMID: 19738459
  • Edgerton M, Morrison C, LiVolsi V, Moskaluk C, Qualman S, Washington M, Grizzle W. A standards based ontological approach to information handling for use by organizations providing human tissue for research. Cancer informatics. 2009;6 127-37. PMID: 19259407 | PMCID: PMC2623300
  • Hagan K, Bienvenue J, Moskaluk C, Landers J. Microchip-based solid-phase purification of RNA from biological samples. Analytical chemistry. 2008;80(22): 8453-60. PMID: 18855414
  • Kuester D, El-Rifai W, Peng D, Ruemmele P, Kroeckel I, Peters B, Moskaluk C, Stolte M, Mönkemüller K, Meyer F, Schulz H, Hartmann A, Roessner A, Schneider-Stock R. Silencing of MGMT expression by promoter hypermethylation in the metaplasia-dysplasia-carcinoma sequence of Barrett's esophagus. Cancer letters. 2008;275(1): 117-26. PMID: 19027227
  • Smith P, Liu Y, Siefert S, Moskaluk C, Petroni G, Jones D. Breast cancer metastasis suppressor 1 (BRMS1) suppresses metastasis and correlates with improved patient survival in non-small cell lung cancer. Cancer letters. 2008;276(2): 196-203. PMID: 19111386
  • Hong S, Cho H, Moskaluk C, Yu E. Measurement of the invasion depth of extrahepatic bile duct carcinoma: An alternative method overcoming the current T classification problems of the AJCC staging system. The American journal of surgical pathology. 2007;31(2): 199-206. PMID: 17255764
  • Peng D, Sheta E, Powell S, Moskaluk C, Washington K, Goldknopf I, El-Rifai W. Alterations in Barrett's-related adenocarcinomas: a proteomic approach. International journal of cancer. Journal international du cancer. 2007;122(6): 1303-10. PMID: 18000824
  • Razvi M, Peng D, Dar A, Powell S, Frierson H, Moskaluk C, Washington K, El-Rifai W. Transcriptional oncogenomic hot spots in Barrett's adenocarcinomas: serial analysis of gene expression. Genes, chromosomes & cancer. 2007;46(10): 914-28. PMID: 17636545
  • Shami V, Sundaram V, Stelow E, Conaway M, Moskaluk C, White G, Adams R, Yeaton P, Kahaleh M. The level of carcinoembryonic antigen and the presence of mucin as predictors of cystic pancreatic mucinous neoplasia. Pancreas. 2007;34(4): 466-9. PMID: 17446847
  • Yu Y, Baras A, Shirasuna K, Frierson H, Moskaluk C. Concurrent loss of heterozygosity and copy number analysis in adenoid cystic carcinoma by SNP genotyping arrays. Laboratory investigation; a journal of technical methods and pathology. 2007;87(5): 430-9. PMID: 17372589
  • Hong S, Presley A, Stelow E, Frierson H, Moskaluk C. Reconsideration of the histologic definitions used in the pathologic staging of extrahepatic bile duct carcinoma. The American journal of surgical pathology. 2006;30(6): 744-9. PMID: 16723853
  • Lee O, Hong S, Razvi M, Peng D, Powell S, Smoklin M, Moskaluk C, El-Rifai W. Expression of calcium-binding proteins S100A2 and S100A4 in Barrett's adenocarcinomas. Neoplasia (New York, N.Y.). 2006;8(10): 843-50. PMID: 17032501 | PMCID: PMC1715926
  • Mobasheri A, Gent T, Nash A, Womack M, Moskaluk C, Barrett-Jolley R. Evidence for functional ATP-sensitive (K(ATP)) potassium channels in human and equine articular chondrocytes. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2006;15(1): 1-8. PMID: 16891130
  • Pramoonjago P, Baras A, Moskaluk C. Knockdown of Sox4 expression by RNAi induces apoptosis in ACC3 cells. Oncogene. 2006;25(41): 5626-39. PMID: 16636670
  • Stelow E, Moskaluk C, Mills S. The mismatch repair protein status of colorectal small cell neuroendocrine carcinomas. The American journal of surgical pathology. 2006;30(11): 1401-4. PMID: 17063080