Christine I. Thisse

Primary Appointment

  • Professor, Cell Biology


Research Interest(s)

Molecular and Cellular Mechanisms of Vertebrate Morphogenesis. Cell Determination and Patterning of the Zebrafish Embryo. Application to Regenerative Medicine and Stem Cell Biology.

Research Description

Dr Christine Thisse is currently studying early development of the vertebrate embryo, using the zebrafish as a model system. Her focus is on the search of factors that instruct the cells to particular fates. She also studies how cells communicate with each other, how they migrate and divide to result at the end into well-shaped organs and organism. Her research is key to emerging field of regenerative medicine and stem cell biology, and has a high impact on our understanding of processes that lead to cancer.

Selected Publications

  • Xu P, Houssin N, Ferri-Lagneau K, Thisse B, Thisse C. Construction of a vertebrate embryo from two opposing morphogen gradients. Science (New York, N.Y.). 2014;344(6179): 87-9. PMID: 24700857
  • Lu F, Thisse C, Thisse B. Identification and mechanism of regulation of the zebrafish dorsal determinant. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(38): 15876-80. PMID: 21911385 | PMCID: PMC3179059
  • Dal-Pra S, Thisse C, Thisse B. FoxA transcription factors are essential for the development of dorsal axial structures. Developmental biology. 2010;350(2): 484-95. PMID: 21172337
  • Fauny J, Thisse B, Thisse C. The entire zebrafish blastula-gastrula margin acts as an organizer dependent on the ratio of Nodal to BMP activity. Development (Cambridge, England). 2009;136(22): 3811-9. PMID: 19855023
  • Bertrand S, Thisse B, Tavares R, Sachs L, Chaumot A, Bardet P, Escrivà H, Duffraisse M, Marchand O, Safi R, Thisse C, Laudet V. Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expression. PLoS genetics. 2007;3(11): e188. PMID: 17997606 | PMCID: PMC2065881
  • Huang H, Lu F, Jia S, Meng S, Cao Y, Wang Y, Ma W, Yin K, Wen Z, Peng J, Thisse C, Thisse B, Meng A. Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation. Development (Cambridge, England). 2007;134(5): 979-88. PMID: 17293535
  • Dal-Pra S, Fürthauer M, Van-Celst J, Thisse B, Thisse C. Noggin1 and Follistatin-like2 function redundantly to Chordin to antagonize BMP activity. Developmental biology. 2006;298(2): 514-26. PMID: 16890217
  • Poulain M, Fürthauer M, Thisse B, Thisse C, Lepage T. Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling. Development (Cambridge, England). 2006;133(11): 2189-200. PMID: 16672336
  • Gamse J, Kuan Y, Macurak M, Brösamle C, Thisse B, Thisse C, Halpern M. Directional asymmetry of the zebrafish epithalamus guides dorsoventral innervation of the midbrain target. Development (Cambridge, England). 2005;132(21): 4869-81. PMID: 16207761
  • Seiliez I, Thisse B, Thisse C. FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulation. Developmental biology. 2005;290(1): 152-63. PMID: 16364286
  • Thisse B, Thisse C. Functions and regulations of fibroblast growth factor signaling during embryonic development. Developmental biology. 2005;287(2): 390-402. PMID: 16216232
  • Fürthauer M, Van Celst J, Thisse C, Thisse B. Fgf signalling controls the dorsoventral patterning of the zebrafish embryo. Development (Cambridge, England). 2004;131(12): 2853-64. PMID: 15151985
  • Galloway J, Wingert R, Thisse C, Thisse B, Zon L. Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos. Developmental cell. 2004;8(1): 109-16. PMID: 15621534
  • Agathon A, Thisse C, Thisse B. The molecular nature of the zebrafish tail organizer. Nature. 2003;424(6947): 448-52. PMID: 12879074
  • Gamse J, Thisse C, Thisse B, Halpern M. The parapineal mediates left-right asymmetry in the zebrafish diencephalon. Development (Cambridge, England). 2003;130(6): 1059-68. PMID: 12571098
  • Ciruna B, Weidinger G, Knaut H, Thisse B, Thisse C, Raz E, Schier A. Production of maternal-zygotic mutant zebrafish by germ-line replacement. Proceedings of the National Academy of Sciences of the United States of America. 2002;99(23): 14919-24. PMID: 12397179 | PMCID: PMC137520
  • David N, Sapède D, Saint-Etienne L, Thisse C, Thisse B, Dambly-Chaudière C, Rosa F, Ghysen A. Molecular basis of cell migration in the fish lateral line: role of the chemokine receptor CXCR4 and of its ligand, SDF1. Proceedings of the National Academy of Sciences of the United States of America. 2002;99(25): 16297-302. PMID: 12444253 | PMCID: PMC138605
  • Fürthauer M, Lin W, Ang S, Thisse B, Thisse C. Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling. Nature cell biology. 2002;4(2): 170-4. PMID: 11802165
  • Herbomel P, Thisse B, Thisse C. Zebrafish early macrophages colonize cephalic mesenchyme and developing brain, retina, and epidermis through a M-CSF receptor-dependent invasive process. Developmental biology. 2002;238(2): 274-88. PMID: 11784010
  • Thisse C, Zon L. Organogenesis--heart and blood formation from the zebrafish point of view. Science (New York, N.Y.). 2002;295(5554): 457-62. PMID: 11799232
  • Weidinger G, Wolke U, Köprunner M, Thisse C, Thisse B, Raz E. Regulation of zebrafish primordial germ cell migration by attraction towards an intermediate target. Development (Cambridge, England). 2002;129(1): 25-36. PMID: 11782398
  • Agathon A, Thisse B, Thisse C. Morpholino knock-down of antivin1 and antivin2 upregulates nodal signaling. Genesis (New York, N.Y. : 2000). 2001;30(3): 178-82. PMID: 11477702
  • Fürthauer M, Reifers F, Brand M, Thisse B, Thisse C. sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish. Development (Cambridge, England). 2001;128(12): 2175-86. PMID: 11493538
  • Gamse J, Shen Y, Thisse C, Thisse B, Raymond P, Halpern M, Liang J. Otx5 regulates genes that show circadian expression in the zebrafish pineal complex. Nature genetics. 2001;30(1): 117-21. PMID: 11753388
  • Kikuchi Y, Agathon A, Alexander J, Thisse C, Waldron S, Yelon D, Thisse B, Stainier D. casanova encodes a novel Sox-related protein necessary and sufficient for early endoderm formation in zebrafish. Genes & development. 2001;15(12): 1493-505. PMID: 11410530 | PMCID: PMC312713
  • Delaunay F, Thisse C, Marchand O, Laudet V, Thisse B. An inherited functional circadian clock in zebrafish embryos. Science (New York, N.Y.). 2000;289(5477): 297-300. PMID: 10894777
  • Neyt C, Jagla K, Thisse C, Thisse B, Haines L, Currie P. Evolutionary origins of vertebrate appendicular muscle. Nature. 2000;408(6808): 82-6. PMID: 11081511
  • Schmid B, Fürthauer M, Connors S, Trout J, Thisse B, Thisse C, Mullins M. Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation. Development (Cambridge, England). 2000;127(5): 957-67. PMID: 10662635
  • Thisse B, Wright C, Thisse C. Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryo. Nature. 2000;403(6768): 425-8. PMID: 10667793
  • Fürthauer M, Thisse B, Thisse C. Three different noggin genes antagonize the activity of bone morphogenetic proteins in the zebrafish embryo. Developmental biology. 1999;214(1): 181-96. PMID: 10491267
  • Herbomel P, Thisse B, Thisse C. Ontogeny and behaviour of early macrophages in the zebrafish embryo. Development (Cambridge, England). 1999;126(17): 3735-45. PMID: 10433904
  • Miller-Bertoglio V, Carmany-Rampey A, Fürthauer M, Gonzalez E, Thisse C, Thisse B, Halpern M, Solnica-Krezel L. Maternal and zygotic activity of the zebrafish ogon locus antagonizes BMP signaling. Developmental biology. 1999;214(1): 72-86. PMID: 10491258
  • Thisse C, Thisse B. Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction. Development (Cambridge, England). 1998;126(2): 229-40. PMID: 9847237
  • Fürthauer M, Thisse C, Thisse B. A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrula. Development (Cambridge, England). 1997;124(21): 4253-64. PMID: 9334274
  • Thisse B, Thisse C, Weston J. Novel FGF receptor (Z-FGFR4) is dynamically expressed in mesoderm and neurectoderm during early zebrafish embryogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 1995;203(3): 377-91. PMID: 8589434
  • Thisse C, Thisse B, Postlethwait J. Expression of snail2, a second member of the zebrafish snail family, in cephalic mesendoderm and presumptive neural crest of wild-type and spadetail mutant embryos. Developmental biology. 1995;172(1): 86-99. PMID: 7589816
  • Thisse C, Thisse B, Halpern M, Postlethwait J. Goosecoid expression in neurectoderm and mesendoderm is disrupted in zebrafish cyclops gastrulas. Developmental biology. 1994;164(2): 420-9. PMID: 8045345
  • Thisse C, Thisse B, Schilling T, Postlethwait J. Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos. Development (Cambridge, England). 1993;119(4): 1203-15. PMID: 8306883
  • Thisse C, Thisse B. Dorsoventral development of the Drosophila embryo is controlled by a cascade of transcriptional regulators. Development (Cambridge, England). Supplement. 1992; 173-81. PMID: 1299363
  • Thisse C, Perrin-Schmitt F, Stoetzel C, Thisse B. Sequence-specific transactivation of the Drosophila twist gene by the dorsal gene product. Cell. 1991;65(7): 1191-201. PMID: 1648449
  • Wolf C, Thisse C, Stoetzel C, Thisse B, Gerlinger P, Perrin-Schmitt F. The M-twist gene of Mus is expressed in subsets of mesodermal cells and is closely related to the Xenopus X-twi and the Drosophila twist genes. Developmental biology. 1991;143(2): 363-73. PMID: 1840517
  • Lu F. I., Sun Y. H., Wei C. Y., Thisse C., Thisse B.. Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/beta-catenin pathway Nat Commun. 5 5368. PMCID: 25371059