Charles R. Farber

Education

  • BS, Western Kentucky University
  • MS, Michigan State University
  • PhD, University of California, Davis
  • Postdoc, University of California, Los Angeles

Primary Appointment

  • Assistant Professor, Public Health Sciences

Contact

Research Interest(s)

Genetics of complex disease, with an emphasis on osteoporosis; Genetics of gene expression; Systems biology of complex disease; Mouse models of complex disease

Research Description

Genetics of complex disease Common diseases, such as osteoporosis, impart significant societal health burdens.  These diseases are, in part, regulated by genetic determinants and understanding their genetic basis is critical to the development of effective therapeutics.  In recent years, technological advances, such as sequencing the genomes of multiple species and the ability to perform bioassays in a massively parallel fashion, have made it possible to begin to understand disease in a systems context.  Systems-biology attempts to determine the direct and interactive roles of all cellular and physiological components (transcripts, proteins, metabolites, etc.) in diseased and normal states using data from high-throughput genomic studies.  

Our lab is using systems approaches to investigate the molecular basis of bone strength.  The goal of this work is to combine genetics and global gene expression profiling in the mouse to identify genes and pathways which influence bone strength related traits using techniques such as causality modeling between expression and physiological traits and generating disease focused gene co-expression networks.  An additional component of this work is testing hypotheses generated by systems-analyses using in vitro cell based assays and transgenic mouse models.

Selected Publications

  • Farber C, Reich A, Barnes A, Becerra P, Rauch F, Cabral W, Bae A, Quinlan A, Glorieux F, Clemens T, Marini J. A Novel IFITM5 Mutation in Severe Atypical Osteogenesis Imperfecta Type VI Impairs Osteoblast Production of Pigment Epithelium-Derived Factor. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2014. PMID: 24519609
  • Mesner L, Ray B, Hsu Y, Manichaikul A, Lum E, Bryda E, Rich S, Rosen C, Criqui M, Allison M, Budoff M, Clemens T, Farber C. Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density. The Journal of clinical investigation. 2014. PMID: 24789909
  • Systems-level analysis of genome-wide association data. G3 (Bethesda, Md.). 2013;3(1): 119-29. PMID: 23316444
  • Calabrese G, Bennett B, Orozco L, Kang H, Eskin E, Dombret C, De Backer O, Lusis A, Farber C. Systems genetic analysis of osteoblast-lineage cells. PLoS genetics. 2013;8(12): e1003150. PMID: 23300464 | PMCID: PMC3531492
  • Orozco L, Bennett B, Farber C, Ghazalpour A, Pan C, Che N, Wen P, Qi H, Mutukulu A, Siemers N, Neuhaus I, Yordanova R, Gargalovic P, Pellegrini M, Kirchgessner T, Lusis A. Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages. Cell. 2012;151(3): 658-70. PMID: 23101632 | PMCID: PMC3513387
  • Farber C, Bennett B, Orozco L, Zou W, Lira A, Kostem E, Kang H, Furlotte N, Berberyan A, Ghazalpour A, Suwanwela J, Drake T, Eskin E, Wang Q, Teitelbaum S, Lusis A. Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis. PLoS genetics. 2011;7(4): e1002038. PMID: 21490954 | PMCID: PMC3072371
  • Identification of a gene module associated with BMD through the integration of network analysis and genome-wide association data. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2010;25(11): 2359-67. PMID: 20499364
  • Bennett B, Farber C, Orozco L, Kang H, Ghazalpour A, Siemers N, Neubauer M, Neuhaus I, Yordanova R, Guan B, Truong A, Yang W, He A, Kayne P, Gargalovic P, Kirchgessner T, Pan C, Castellani L, Kostem E, Furlotte N, Drake T, Eskin E, Lusis A. A high-resolution association mapping panel for the dissection of complex traits in mice. Genome research. 2010;20(2): 281-90. PMID: 20054062
  • Hsu Y, Zillikens M, Wilson S, Farber C, Demissie S, Soranzo N, Bianchi E, Grundberg E, Liang L, Richards J, Estrada K, Zhou Y, van Nas A, Moffatt M, Zhai G, Hofman A, van Meurs J, Pols H, Price R, Nilsson O, Pastinen T, Cupples L, Lusis A, Schadt E, Ferrari S, Uitterlinden A, Rivadeneira F, Spector T, Karasik D, Kiel D. An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. PLoS genetics. 2010;6(6): e1000977. PMID: 20548944 | PMCID: PMC2883588