Chance John Luckey


  • MD/PhD, University of Virginia
  • BA, University of Georgia

Primary Appointment

  • Associate Professor of Pathology, Pathology


Research Interest(s)

Immune Memory

Research Description


We work on cytokine control of memory lymphocytes, with a particular interest in the molecular regulators of vaccination and pathological antibodies in different disease states. Experimentally, we use i) mouse model systems of both vaccination and RBC alloimmunization as well as ii) study cytokine control of lymphocyte development in healthy humans and at-risk patients.

Selected Publications

  • Farh K, Marson A, Zhu J, Kleinewietfeld M, Housley W, Beik S, Shoresh N, Whitton H, Ryan R, Shishkin A, Hatan M, Carrasco-Alfonso M, Mayer D, Luckey C, Patsopoulos N, De Jager P, Kuchroo V, Epstein C, Daly M, Hafler D, Bernstein B. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature. 2014;518(7539): 337-43. PMID: 25363779 | PMCID: PMC4336207
  • Lu Y, Loh Y, Li H, Cesana M, Ficarro S, Parikh J, Salomonis N, Toh C, Andreadis S, Luckey C, Collins J, Daley G, Marto J. Alternative splicing of MBD2 supports self-renewal in human pluripotent stem cells. Cell stem cell. 2014;15(1): 92-101. PMID: 24813856 | PMCID: PMC4082735
  • Quillen K, Luckey C. Blood and bombs: blood use after the Boston Marathon bombing of April 15, 2013. Transfusion. 2014;54(4): 1202-3. PMID: 24724792
  • Babic A, Jang S, Nicolov E, Voicu H, Luckey C. Culture of mouse amniotic fluid-derived cells on irradiated STO feeders results in the generation of primitive endoderm cell lines capable of self-renewal in vitro. Cells, tissues, organs. 2013;198(2): 111-26. PMID: 24060676 | PMCID: PMC3914766
  • Luckey C, Silberstein L. A mouse model of hemolytic disease of the newborn. Blood. 2013;122(8): 1334-5. PMID: 23970354
  • Zhou F, Lu Y, Ficarro S, Adelmant G, Jiang W, Luckey C, Marto J. Genome-scale proteome quantification by DEEP SEQ mass spectrometry. Nature communications. 2013;4 2171. PMID: 23863870 | PMCID: PMC3770533
  • Koleva R, Ficarro S, Radomska H, Carrasco-Alfonso M, Alberta J, Webber J, Luckey C, Marcucci G, Tenen D, Marto J. C/EBPα and DEK coordinately regulate myeloid differentiation. Blood. 2012;119(21): 4878-88. PMID: 22474248 | PMCID: PMC3367892
  • Luckey C, Weaver C. Stem-cell-like qualities of immune memory; CD4+ T cells join the party. Cell stem cell. 2012;10(2): 107-8. PMID: 22305557 | PMCID: PMC3277283
  • Ficarro S, Zhang Y, Carrasco-Alfonso M, Garg B, Adelmant G, Webber J, Luckey C, Marto J. Online nanoflow multidimensional fractionation for high efficiency phosphopeptide analysis. Molecular & cellular proteomics : MCP. 2011;10(11): O111.011064. PMID: 21788404 | PMCID: PMC3226414
  • Luckey C, Lu Y, Marto J. Understanding the first steps in embryonic stem cell exit from the pluripotent state. Transfusion. 2011;51 118S-124S. PMID: 22074622 | PMCID: PMC3293186
  • Ficarro S, Zhang Y, Lu Y, Moghimi A, Askenazi M, Hyatt E, Smith E, Boyer L, Schlaeger T, Luckey C, Marto J. Improved electrospray ionization efficiency compensates for diminished chromatographic resolution and enables proteomics analysis of tyrosine signaling in embryonic stem cells. Analytical chemistry. 2009;81(9): 3440-7. PMID: 19331382
  • Zhang Y, Askenazi M, Jiang J, Luckey C, Griffin J, Marto J. A robust error model for iTRAQ quantification reveals divergent signaling between oncogenic FLT3 mutants in acute myeloid leukemia. Molecular & cellular proteomics : MCP. 2009;9(5): 780-90. PMID: 20019052 | PMCID: PMC2871413
  • Luckey C, Bhattacharya D, Goldrath A, Weissman I, Benoist C, Mathis D. Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 2006;103(9): 3304-9. PMID: 16492737 | PMCID: PMC1413911
  • Goldrath A, Luckey C, Park R, Benoist C, Mathis D. The molecular program induced in T cells undergoing homeostatic proliferation. Proceedings of the National Academy of Sciences of the United States of America. 2004;101(48): 16885-90. PMID: 15548615 | PMCID: PMC534746
  • Zarling A, Luckey C, Marto J, White F, Brame C, Evans A, Lehner P, Cresswell P, Shabanowitz J, Hunt D, Engelhard V. Tapasin is a facilitator, not an editor, of class I MHC peptide binding. Journal of immunology (Baltimore, Md. : 1950). 2003;171(10): 5287-95. PMID: 14607930
  • Lippolis J, White F, Marto J, Luckey C, Bullock T, Shabanowitz J, Hunt D, Engelhard V. Analysis of MHC class II antigen processing by quantitation of peptides that constitute nested sets. Journal of immunology (Baltimore, Md. : 1950). 2002;169(9): 5089-97. PMID: 12391225
  • Luckey C, Marto J, Partridge M, Hall E, White F, Lippolis J, Shabanowitz J, Hunt D, Engelhard V. Differences in the expression of human class I MHC alleles and their associated peptides in the presence of proteasome inhibitors. Journal of immunology (Baltimore, Md. : 1950). 2001;167(3): 1212-21. PMID: 11466336
  • Nepom G, Lippolis J, White F, Masewicz S, Marto J, Herman A, Luckey C, Falk B, Shabanowitz J, Hunt D, Engelhard V, Nepom B. Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65). Proceedings of the National Academy of Sciences of the United States of America. 2001;98(4): 1763-8. PMID: 11172025 | PMCID: PMC29331
  • Colella T, Bullock T, Russell L, Mullins D, Overwijk W, Luckey C, Pierce R, Restifo N, Engelhard V. Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy. The Journal of experimental medicine. 2000;191(7): 1221-32. PMID: 10748239 | PMCID: PMC2193167
  • Luckey C, King G, Marto J, Venketeswaran S, Maier B, Crotzer V, Colella T, Shabanowitz J, Hunt D, Engelhard V. Proteasomes can either generate or destroy MHC class I epitopes: evidence for nonproteasomal epitope generation in the cytosol. Journal of immunology (Baltimore, Md. : 1950). 1998;161(1): 112-21. PMID: 9647214
  • Mosse C, Meadows L, Luckey C, Kittlesen D, Huczko E, Slingluff C, Shabanowitz J, Hunt D, Engelhard V. The class I antigen-processing pathway for the membrane protein tyrosinase involves translation in the endoplasmic reticulum and processing in the cytosol. The Journal of experimental medicine. 1998;187(1): 37-48. PMID: 9419209 | PMCID: PMC2199193
  • Man S, Newberg M, Crotzer V, Luckey C, Williams N, Chen Y, Huczko E, Ridge J, Engelhard V. Definition of a human T cell epitope from influenza A non-structural protein 1 using HLA-A2.1 transgenic mice. International immunology. 1995;7(4): 597-605. PMID: 7547687
  • Zhang J, Luckey C, Lazarow P. Three peroxisome protein packaging pathways suggested by selective permeabilization of yeast mutants defective in peroxisome biogenesis. Molecular biology of the cell. 1993;4(12): 1351-9. PMID: 7909460 | PMCID: PMC275770