Bryce M. Paschal


  • Postdoc, The Scripps Research Institute, La Jolla, CA
  • BA, University of North Carolina, Chapel Hill, NC
  • PhD, University of Massachusetts Medical School, MA

Primary Appointment

  • Professor, Biochemistry and Molecular Genetics


Research Interest(s)

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Research Description

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Selected Publications

  • Datta S, Snow C, Paschal B. A pathway linking oxidative stress and the Ran GTPase system in progeria. Molecular biology of the cell. 2014;25(8): 1202-15. PMID: 24523287 | PMCID: PMC3982987
  • Bjerke G, Yang C, Frierson H, Paschal B, Wotton D. Activation of Akt signaling in prostate induces a TGFβ-mediated restraint on cancer progression and metastasis. Oncogene. 2013. PMID: 23995785 | PMCID: PMC3939071
  • Ni L, Llewellyn R, Kesler C, Kelley J, Spencer A, Snow C, Shank L, Paschal B. Androgen induces a switch from cytoplasmic retention to nuclear import of the androgen receptor. Molecular and cellular biology. 2013;33(24): 4766-78. PMID: 24100013 | PMCID: PMC3889559
  • Paciorkowski A, Weisenberg J, Kelley J, Spencer A, Tuttle E, Ghoneim D, Thio L, Christian S, Dobyns W, Paschal B. Autosomal recessive mutations in nuclear transport factor KPNA7 are associated with infantile spasms and cerebellar malformation. European journal of human genetics : EJHG. 2013;22(5): 587-93. PMID: 24045845 | PMCID: PMC3992559
  • Snow C, Dar A, Dutta A, Kehlenbach R, Paschal B. Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport. The Journal of cell biology. 2013;201(4): 541-57. PMID: 23649804 | PMCID: PMC3653351
  • Sun D, Layer R, Mueller A, Cichewicz M, Negishi M, Paschal B, Dutta A. Regulation of several androgen-induced genes through the repression of the miR-99a/let-7c/miR-125b-2 miRNA cluster in prostate cancer cells. Oncogene. 2013. PMID: 23503464 | PMCID: PMC3915043
  • Kelley J, Datta S, Snow C, Chatterjee M, Ni L, Spencer A, Yang C, Cubeñas-Potts C, Matunis M, Paschal B. The defective nuclear lamina in Hutchinson-gilford progeria syndrome disrupts the nucleocytoplasmic Ran gradient and inhibits nuclear localization of Ubc9. Molecular and cellular biology. 2011;31(16): 3378-95. PMID: 21670151 | PMCID: PMC3147792
  • Kelley J, Talley A, Spencer A, Gioeli D, Paschal B. Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors. BMC cell biology. 2010;11 63. PMID: 20701745 | PMCID: PMC2929220
  • Ni L, Yang C, Gioeli D, Frierson H, Toft D, Paschal B. FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells. Molecular and cellular biology. 2010;30(5): 1243-53. PMID: 20048054 | PMCID: PMC2820886
  • Galgano M, Conaway M, Spencer A, Paschal B, Frierson H. PRK1 distribution in normal tissues and carcinomas: overexpression and activation in ovarian serous carcinoma. Human pathology. 2009;40(10): 1434-40. PMID: 19427017 | PMCID: PMC2744839
  • Kelley J, Paschal B. Hyperosmotic stress signaling to the nucleus disrupts the Ran gradient and the production of RanGTP. Molecular biology of the cell. 2007;18(11): 4365-76. PMID: 17761537 | PMCID: PMC2043571
  • Yang C, Xin H, Kelley J, Spencer A, Brautigan D, Paschal B. Ligand binding to the androgen receptor induces conformational changes that regulate phosphatase interactions. Molecular and cellular biology. 2007;27(9): 3390-404. PMID: 17325038 | PMCID: PMC1899975