Bettina Winckler

Education

  • BA, Swarthmore College
  • PhD, Massachusetts Institute of Technology
  • Postdoc, Columbia University
  • Postdoc, Yale University

Primary Appointment

  • Professor, Neuroscience

Contact

Research Interest(s)

Endosomal function and dysfunction in neurons.

Research Description

Many diseases of the nervous system (neurodevelopmental and neurodegenerative) as well as degenerative and regenerative processes after injury can be traced at the cellular level to disruptions of endolysosomal pathways, including autophagy. For example, Alzheimer’s disease, Huntington’s disease, and nerve injury all show profound defects in endosomal trafficking. This is not surprising given the central role of the endolysosomal system in regulating not only “cellular trash removal,” but also the quantity and quality of signaling cascades. The Winckler lab has unique expertise in studying endolysosomal trafficking in neurons and has shown that endosomes in neurons use different molecular machineries from non-polarized cells (Yap et al., 2008; Yap et al. 2010, Lasiecka et al. 2010; Yap et al. 2012; Lasiecka et al., 2014). We are particularly interested in the roles neuronal-specific proteins, (for example the neuronal-enriched endosomal protein NEEP21) play in neuronal endosomes. We are making extensive use of live imaging to understand the function and regulation of neuronal endosomes.

Selected Publications

  • Lasiecka Z, Yap C, Katz J, Winckler B. Maturational conversion of dendritic early endosomes and their roles in l1-mediated axon growth. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014;34(44): 14633-43. PMID: 25355216 | PMCID: PMC4212064
  • Dey D, Eckle V, Vitko I, Sullivan K, Lasiecka Z, Winckler B, Stornetta R, Williamson J, Kapur J, Perez-Reyes E. A potassium leak channel silences hyperactive neurons and ameliorates status epilepticus. Epilepsia. 2013;55(2): 203-13. PMID: 24299204 | PMCID: PMC4161023
  • Yap C, Vakulenko M, Kruczek K, Motamedi B, Digilio L, Liu J, Winckler B. Doublecortin (DCX) mediates endocytosis of neurofascin independently of microtubule binding. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012;32(22): 7439-53. PMID: 22649224 | PMCID: PMC3372911
  • Yap C, Winckler B. Harnessing the power of the endosome to regulate neural development. Neuron. 2012;74(3): 440-51. PMID: 22578496 | PMCID: PMC3351757
  • Lasiecka Z, Winckler B. Mechanisms of polarized membrane trafficking in neurons -- focusing in on endosomes. Molecular and cellular neurosciences. 2011;48(4): 278-87. PMID: 21762782 | PMCID: PMC3205304
  • Winckler B, Choo Yap C. Endocytosis and endosomes at the crossroads of regulating trafficking of axon outgrowth-modifying receptors. Traffic (Copenhagen, Denmark). 2011;12(9): 1099-108. PMID: 21535338 | PMCID: PMC3155643
  • Bettina Winckler: neuronal polarity on her mind. Interviwed by Caitlin Sedwick. The Journal of cell biology. 2010;191(1): 4-5. PMID: 20921132 | PMCID: PMC2953440
  • Dwyer N, Winckler B. TGF-beta receptors PAR-ticipate in axon formation. Cell. 2010;142(1): 21-3. PMID: 20603011
  • Lasiecka Z, Yap C, Caplan S, Winckler B. Neuronal early endosomes require EHD1 for L1/NgCAM trafficking. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010;30(49): 16485-97. PMID: 21147988 | PMCID: PMC3004753
  • Winckler B, Mellman I. Trafficking guidance receptors. Cold Spring Harbor perspectives in biology. 2010;2(7): a001826. PMID: 20504966 | PMCID: PMC2890194
  • Winckler B, Mellman I. Trafficking guidance receptors. Cold Spring Harbor perspectives in biology. 2010;2(7): a001826. PMID: 20504966 | PMCID: PMC2890194
  • Yap C, Lasiecka Z, Caplan S, Winckler B. Alterations of EHD1/EHD4 protein levels interfere with L1/NgCAM endocytosis in neurons and disrupt axonal targeting. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010;30(19): 6646-57. PMID: 20463227 | PMCID: PMC2905050
  • Yap C, Wisco D, Kujala P, Lasiecka Z, Cannon J, Chang M, Hirling H, Klumperman J, Winckler B. The somatodendritic endosomal regulator NEEP21 facilitates axonal targeting of L1/NgCAM. The Journal of cell biology. 2008;180(4): 827-42. PMID: 18299352 | PMCID: PMC2265569