Benjamin W. Purow

Education

  • MD, Johns Hopkins University-Baltimore, MD
  • BA, Harvard University-Cambridge, MA

Primary Appointment

  • Professor, Neurology

Contact

Research Interest(s)

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Research Description

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Selected Publications

  • Floyd D, Zhang Y, Dey B, Kefas B, Breit H, Marks K, Dutta A, Herold-Mende C, Synowitz M, Glass R, Abounader R, Purow B. Novel anti-apoptotic microRNAs 582-5p and 363 promote human glioblastoma stem cell survival via direct inhibition of caspase 3, caspase 9, and Bim. PloS one. 2014;9(5): e96239. PMID: 24805821 | PMCID: PMC4013090
  • Dominguez C, Floyd D, Xiao A, Mullins G, Kefas B, Xin W, Yacur M, Abounader R, Lee J, Wilson G, Harris T, Purow B. Diacylglycerol kinase α is a critical signaling node and novel therapeutic target in glioblastoma and other cancers. Cancer discovery. 2013;3(7): 782-97. PMID: 23558954 | PMCID: PMC3710531
  • Notch inhibition as a promising new approach to cancer therapy. Advances in experimental medicine and biology. 2012;727 305-19. PMID: 22399357 | PMCID: PMC3361718
  • Floyd D, Kefas B, Seleverstov O, Mykhaylyk O, Dominguez C, Comeau L, Plank C, Purow B. Alpha-secretase inhibition reduces human glioblastoma stem cell growth in vitro and in vivo by inhibiting Notch. Neuro-oncology. 2012;14(10): 1215-26. PMID: 22962413 | PMCID: PMC3452340
  • Sherman J, Redpath G, Redick J, Purow B, Laws E, Jane J, Shaffrey M, Hussaini I. A novel fixative for immunofluorescence staining of CD133-positive glioblastoma stem cells. Journal of neuroscience methods. 2011;198(1): 99-102. PMID: 21402102 | PMCID: PMC3126626
  • Kefas B, Comeau L, Erdle N, Montgomery E, Amos S, Purow B. Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells. Neuro-oncology. 2010;12(11): 1102-12. PMID: 20667897 | PMCID: PMC3098027
  • Purow B, Schiff D. Glioblastoma genetics: in rapid flux. Discovery medicine. 2010;9(45): 125-31. PMID: 20193638 | PMCID: PMC3365574
  • Notch inhibitors as a new tool in the war on cancer: a pathway to watch. Current pharmaceutical biotechnology. 2009;10(2): 154-60. PMID: 19199947 | PMCID: PMC3365567
  • Kefas B, Comeau L, Floyd D, Seleverstov O, Godlewski J, Schmittgen T, Jiang J, diPierro C, Li Y, Chiocca E, Lee J, Fine H, Abounader R, Lawler S, Purow B. The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009;29(48): 15161-8. PMID: 19955368 | PMCID: PMC2823067
  • Li Y, Guessous F, Zhang Y, Dipierro C, Kefas B, Johnson E, Marcinkiewicz L, Jiang J, Yang Y, Schmittgen T, Lopes B, Schiff D, Purow B, Abounader R. MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer research. 2009;69(19): 7569-76. PMID: 19773441 | PMCID: PMC2756313
  • Purow B, Schiff D. Advances in the genetics of glioblastoma: are we reaching critical mass? Nature reviews. Neurology. 2009;5(8): 419-26. PMID: 19597514 | PMCID: PMC3387541