Barbara J. Mann
- PhD, University of Virginia
- Associate Professor, Medicine- Infectious Diseases and International Health
- Phone: 434-924-9666
- Email: email@example.com
Pathogenicity of Francisella tularensis and vaccines
My research interests focus on the initial interactions between the pathogenic bacteria Francisella tularensis and its host. I am specifically interested in adherence and invasion mechanisms, and protective vaccines. F. tularensis has been designated as a category A select agent for studies in Biodefense Research.
Francisella tularensis is a zoonotic infection that can be contracted by several methods including tick bites and inhalation. The low infection dose of 10-50 organisms by an inhalation route led to its development as an agent of biological warfare. The molecular mechanisms of pathogenicity of this gram negative, intracellular bacteria are largely unknown. We are using combined approaches that include bioinformatics, and mutagenesis to identify proteins that mediate adherence to and invasion of host cells. We are also screening for attenuated strains that may be useful as protective vaccines.
- Schaenman J, Driscoll P, Hockensmith J, Mann B, Petri W. An upstream regulatory element containing two nine basepair repeats regulates expression of the Entamoeba histolytica hgl5 lectin gene. Molecular and biochemical parasitology. 1998;94(2): 309-13. PMID: 9747982
- Singh U, Gilchrist C, Schaenman J, Rogers J, Hockensmith J, Mann B, Petri W. Context-dependent roles of the Entamoeba histolytica core promoter element GAAC in transcriptional activation and protein complex assembly. Molecular and biochemical parasitology. 2002;120(1): 107-16. PMID: 11849710
- Richard K, Mann B, Stocker L, Barry E, Qin A, Cole L, Hurley M, Ernst R, Michalek S, Stein D, Deshong P, Vogel S. Novel Catanionic Surfactant Vesicle Vaccines Protect Mice against Francisella tularensis LVS and Confer Significant Partial Protection against F. tularensis Schu S4. Clinical and vaccine immunology : CVI. 2013. PMID: 24351755
- Collins E, Mann B, Wadsworth P. Eg5 restricts anaphase B spindle elongation in mammalian cells. Cytoskeleton (Hoboken, N.J.). 2013. PMID: 24285623
- Rosch J, Iverson A, Humann J, Mann B, Gao G, Vogel P, Mina M, Murrah K, Perez A, Edward Swords W, Tuomanen E, McCullers J. A live-attenuated pneumococcal vaccine elicits CD4+ T-cell dependent class switching and provides serotype independent protection against acute otitis media. EMBO molecular medicine. 2014;6(1): 141-54. PMID: 24408968