B. Jill Venton


  • BS, University of Delaware
  • PhD, University of North Carolina
  • Postdoc, University of Michigan

Primary Appointment

  • Professor, Chemistry


Research Interest(s)

Analytical Neurochemistry; Dopamine and Serotonin Neurotransmission in Drosophila; Mechanisms of rapid adenosine signaling in rodents

Research Description

Analytical Neurochemistry

I am interested in the development and characterization of analytical techniques to measure neurochemical changes. Measurements in the brain are challenging because zeptomole quantities of neuroactive molecules must be detected in a chemically-complex sample while disturbing the tissue as little as possible. In addition, fast time resolution measurements are needed to track the fast dynamics of neurotransmitter release and uptake. The development of new analytical tools will enable a better understanding of the central nervous system which will, in turn, facilitate the development of new treatments for neurological disorders. Electrochemical Detection of Adenosine

The goal of this project is to develop an electrochemical detection method for real-time monitoring of adenosine concentrations. Adenosine is a neuromodulator in the brain that has a variety of actions including regulation of cerebral blood flow, modulation of neurotransmission, and protection against neuronal injury during stroke. There is currently no reliable method for electrochemical detection of adenosine in vivo. Direct detection of adenosine using cyclic voltammetry at carbon-fiber microelectrodes is detected. The sensor is used to characterize extracellular adenosine release in the rat brain following electrical stimulation of neuronal activity and during ischemia, a model of stroke. Simultaneous monitoring of adenosine, oxygen and dopamine concentrations will allow studies of how adenosine modulates neurotransmission and cerebral blood flow. We are studying the modulation of adenosine during stroke.

Measurements of Neurotransmitters in Drosophila Our lab also measures neurotransmitters in the Drosophila CNS. We use optogenetics as well as acetylcholine stimulations to elicit dopamine and serotonin release in the brain. We expect to study Parkinson models and test how dopamine differs through the life cycle of the fly.

Selected Publications

  • Cao Q, Puthongkham P, Venton B. Review: New insights into optimizing chemical and 3D surface structures of carbon electrodes for neurotransmitter detection. Analytical methods : advancing methods and applications. 2019;11(3): 247-261. PMID: 30740148 | PMCID: PMC6366673
  • Ganesana M, Trikantzopoulos E, Maniar Y, Lee S, Venton B. Development of a novel micro biosensor for in vivo monitoring of glutamate release in the brain. Biosensors & bioelectronics. 2019;130 103-109. PMID: 30731343
  • Puthongkham P, Yang C, Venton B. Carbon Nanohorn-Modified Carbon Fiber Microelectrodes for Dopamine Detection. Electroanalysis. 2019;30(6): 1073-1081. PMID: 30613128 | PMCID: PMC6317378
  • Shin M, Wang Y, Borgus J, Venton B. Electrochemistry at the Synapse. Annual review of analytical chemistry (Palo Alto, Calif.). 2019. PMID: 30707593
  • Yang C, Hu K, Wang D, Zubi Y, Lee S, Puthongkham P, Mirkin M, Venton B. Cavity Carbon-Nanopipette Electrodes for Dopamine Detection. Analytical chemistry. 2019. PMID: 30810304
  • Ganesana M, Venton B. Early changes in transient adenosine during cerebral ischemia and reperfusion injury. PloS one. 2018;13(5): e0196932. PMID: 29799858
  • Haynes C, Hummon A, Venton B. Virtual Issue Highlighting Selected Women Analytical Chemists. Analytical chemistry. 2018;90(3): 1433. PMID: 29409170
  • Pyakurel P, Shin M, Venton B. Nicotinic acetylcholine receptor (nAChR) mediated dopamine release in larval Drosophila melanogaster. Neurochemistry international. 2018;114 33-41. PMID: 29305920 | PMCID: PMC5835409
  • Shin M, Copeland J, Venton B. Drosophila as a Model System for Neurotransmitter Measurements. ACS chemical neuroscience. 2018. PMID: 29411967
  • Shin M, Venton B. Electrochemical Measurements of Acetylcholine-Stimulated Dopamine Release in Adult Drosophila melanogaster Brains. Analytical chemistry. 2018;90(17): 10318-10325. PMID: 30073836 | PMCID: PMC6135655
  • Wang Y, Venton B. Caffeine Modulates Spontaneous Adenosine and Oxygen Changes during Ischemia and Reperfusion. ACS chemical neuroscience. 2018. PMID: 30252436
  • Wang Y, Venton B. Comparison of spontaneous and mechanically-stimulated adenosine release in mice. Neurochemistry international. 2018;124 46-50. PMID: 30579856 | PMCID: PMC6369016
  • Yang C, Cao Q, Puthongkham P, Lee S, Ganesana M, Lavrik N, Venton B. 3D-Printed Carbon Electrodes for Neurotransmitter Detection. Angewandte Chemie (International ed. in English). 2018;57(43): 14255-14259. PMID: 30207021 | PMCID: PMC6334753
  • Zestos A, Venton B. Communication-Carbon Nanotube Fiber Microelectrodes for High Temporal Measurements of Dopamine. Journal of the Electrochemical Society. 2018;165(12): G3071-G3073. PMID: 30197450 | PMCID: PMC6121781
  • Borman R, Wang Y, Nguyen M, Ganesana M, Lee S, Venton B. Automated Algorithm for Detection of Transient Adenosine Release. ACS chemical neuroscience. 2017;8(2): 386-393. PMID: 28196418 | PMCID: PMC5312768
  • Ganesana M, Lee S, Wang Y, Venton B. Analytical Techniques in Neuroscience: Recent Advances in Imaging, Separation, and Electrochemical Methods. Analytical chemistry. 2017;89(1): 314-341. PMID: 28105819 | PMCID: PMC5260807
  • Lee S, Venton B. Regional Variations of Spontaneous, Transient Adenosine Release in Brain Slices. ACS chemical neuroscience. 2017;9(3): 505-513. PMID: 29135225
  • Nguyen M, Wang Y, Ganesana M, Venton B. Transient Adenosine Release Is Modulated by NMDA and GABAB Receptors. ACS chemical neuroscience. 2017;8(2): 376-385. PMID: 28071892 | PMCID: PMC5558448
  • Yang C, Trikantzopoulos E, Jacobs C, Venton B. Evaluation of carbon nanotube fiber microelectrodes for neurotransmitter detection: Correlation of electrochemical performance and surface properties. Analytica chimica acta. 2017;965 1-8. PMID: 28366206 | PMCID: PMC5380235
  • Yang C, Venton B. High Performance, Low Cost Carbon Nanotube Yarn based 3D Printed Electrodes Compatible with a Conventional Screen Printed Electrode System. IEEE International Symposium on Medical Measurements and Applications : proceedings. IEEE International Symposium on Medical Measurements and Applications. 2017;2017 100-105. PMID: 28890951 | PMCID: PMC5589149
  • Yang C, Wang Y, Jacobs C, Ivanov I, Venton B. O2 Plasma Etching and Antistatic Gun Surface Modifications for CNT Yarn Microelectrode Improve Sensitivity and Antifouling Properties. Analytical chemistry. 2017;89(10): 5605-5611. PMID: 28423892 | PMCID: PMC5575992
  • Denno M, Privman E, Borman R, Wolin D, Venton B. Quantification of Histamine and Carcinine in Drosophila melanogaster Tissues. ACS chemical neuroscience. 2016;7(3): 407-14. PMID: 26765065 | PMCID: PMC4798850
  • Nguyen M, Ross A, Ryals M, Lee S, Venton B. Clearance of rapid adenosine release is regulated by nucleoside transporters and metabolism. Pharmacology research & perspectives. 2016;3(6): e00189. PMID: 27022463 | PMCID: PMC4777247
  • Nguyen M, Venton B. Fast-scan Cyclic Voltammetry for the Characterization of Rapid Adenosine Release. Computational and structural biotechnology journal. 2016;13 47-54. PMID: 26900429 | PMCID: PMC4720017
  • Pyakurel P, Privman Champaloux E, Venton B. Fast-Scan Cyclic Voltammetry (FSCV) Detection of Endogenous Octopamine in Drosophila melanogaster Ventral Nerve Cord. ACS chemical neuroscience. 2016;7(8): 1112-9. PMID: 27326831 | PMCID: PMC4988909
  • Trikantzopoulos E, Yang C, Ganesana M, Wang Y, Venton B. Novel carbon-fiber microelectrode batch fabrication using a 3D-printed mold and polyimide resin. The Analyst. 2016;141(18): 5256-5260. PMID: 27536741 | PMCID: PMC5019535
  • Wang Y, Venton B. Correlation of transient adenosine release and oxygen changes in the caudate-putamen. Journal of neurochemistry. 2016;140(1): 13-23. PMID: 27314215 | PMCID: PMC5164875
  • Yang C, Trikantzopoulos E, Nguyen M, Jacobs C, Wang Y, Mahjouri-Samani M, Ivanov I, Venton B. Laser Treated Carbon Nanotube Yarn Microelectrodes for Rapid and Sensitive Detection of Dopamine in Vivo. ACS sensors. 2016;1(5): 508-515. PMID: 27430021 | PMCID: PMC4944855
  • Privman E, Venton B. Comparison of dopamine kinetics in the larval Drosophila ventral nerve cord and protocerebrum with improved optogenetic stimulation. Journal of neurochemistry. 2015;135(4): 695-704. PMID: 26296526 | PMCID: PMC4636934
  • Rees H, Anderson S, Privman E, Bau H, Venton B. Carbon nanopipette electrodes for dopamine detection in Drosophila. Analytical chemistry. 2015;87(7): 3849-55. PMID: 25711512 | PMCID: PMC4400659
  • Xiao N, Venton B. Characterization of dopamine releasable and reserve pools in Drosophila larvae using ATP/P2X2 -mediated stimulation. Journal of neurochemistry. 2015;134(3): 445-54. PMID: 25951875 | PMCID: PMC4496298
  • Yang C, Denno M, Pyakurel P, Venton B. Recent trends in carbon nanomaterial-based electrochemical sensors for biomolecules: A review. Analytica chimica acta. 2015;887 17-37. PMID: 26320782 | PMCID: PMC4557208
  • Yang C, Jacobs C, Nguyen M, Ganesana M, Zestos A, Ivanov I, Puretzky A, Rouleau C, Geohegan D, Venton B. Carbon Nanotubes Grown on Metal Microelectrodes for the Detection of Dopamine. Analytical chemistry. 2015;88(1): 645-52. PMID: 26639609 | PMCID: PMC4718531
  • Zestos A, Yang C, Jacobs C, Hensley D, Venton B. Carbon nanospikes grown on metal wires as microelectrode sensors for dopamine. The Analyst. 2015;140(21): 7283-92. PMID: 26389138 | PMCID: PMC4618699
  • Jacobs C, Ivanov I, Nguyen M, Zestos A, Venton B. High temporal resolution measurements of dopamine with carbon nanotube yarn microelectrodes. Analytical chemistry. 2014;86(12): 5721-7. PMID: 24832571 | PMCID: PMC4063327
  • Nguyen M, Lee S, Ross A, Ryals M, Choudhry V, Venton B. Characterization of spontaneous, transient adenosine release in the caudate-putamen and prefrontal cortex. PloS one. 2014;9(1): e87165. PMID: 24494035 | PMCID: PMC3907895
  • Ross A, Nguyen M, Privman E, Venton B. Mechanical stimulation evokes rapid increases in extracellular adenosine concentration in the prefrontal cortex. Journal of neurochemistry. 2014;130(1): 50-60. PMID: 24606335 | PMCID: PMC4065624
  • Ross A, Venton B. Adenosine transiently modulates stimulated dopamine release in the caudate-putamen via A1 receptors. Journal of neurochemistry. 2014. PMID: 25219576
  • Ross A, Venton B. Sawhorse waveform voltammetry for selective detection of adenosine, ATP, and hydrogen peroxide. Analytical chemistry. 2014;86(15): 7486-93. PMID: 25005825
  • Xiao N, Privman E, Venton B. Optogenetic control of serotonin and dopamine release in Drosophila larvae. ACS chemical neuroscience. 2014;5(8): 666-73. PMID: 24849718 | PMCID: PMC4140588
  • Zestos A, Jacobs C, Trikantzopoulos E, Ross A, Venton B. Polyethylenimine carbon nanotube fiber electrodes for enhanced detection of neurotransmitters. Analytical chemistry. 2014;86(17): 8568-75. PMID: 25117550 | PMCID: PMC4151793
  • Fang H, Pajski M, Ross A, Venton B. Quantitation of dopamine, serotonin and adenosine content in a tissue punch from a brain slice using capillary electrophoresis with fast-scan cyclic voltammetry detection. Analytical methods : advancing methods and applications. 2013;5(11): 2704-2711. PMID: 23795210 | PMCID: PMC3686531
  • Vickrey T, Xiao N, Venton B. Kinetics of the dopamine transporter in Drosophila larva. ACS chemical neuroscience. 2013;4(5): 832-7. PMID: 23600464 | PMCID: PMC3656763
  • Glanowska K, Venton B, Moenter S. Fast scan cyclic voltammetry as a novel method for detection of real-time gonadotropin-releasing hormone release in mouse brain slices. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012;32(42): 14664-9. PMID: 23077052 | PMCID: PMC3492948
  • Pajski M, Venton B. The mechanism of electrically stimulated adenosine release varies by brain region. Purinergic signalling. 2012. PMID: 23192278 | PMCID: PMC3646118
  • Ross A, Venton B. Nafion-CNT coated carbon-fiber microelectrodes for enhanced detection of adenosine. The Analyst. 2012;137(13): 3045-51. PMID: 22606688 | PMCID: PMC3392196
  • Vickrey T, Venton B. Drosophila Dopamine2-like receptors function as autoreceptors. ACS chemical neuroscience. 2012;2(12): 723-729. PMID: 22308204 | PMCID: PMC3269839
  • Xiao N, Venton B. Rapid, sensitive detection of neurotransmitters at microelectrodes modified with self-assembled SWCNT forests. Analytical chemistry. 2012;84(18): 7816-22. PMID: 22823497 | PMCID: PMC3445787
  • Fang H, Vickrey T, Venton B. Analysis of biogenic amines in a single Drosophila larva brain by capillary electrophoresis with fast-scan cyclic voltammetry detection. Analytical chemistry. 2011;83(6): 2258-64. PMID: 21322586 | PMCID: PMC3058613
  • Jacobs C, Vickrey T, Venton B. Functional groups modulate the sensitivity and electron transfer kinetics of neurochemicals at carbon nanotube modified microelectrodes. The Analyst. 2011;136(17): 3557-65. PMID: 21373669 | PMCID: PMC4169050
  • Pajski M, Venton B. Adenosine Release Evoked by Short Electrical Stimulations in Striatal Brain Slices is Primarily Activity Dependent. ACS chemical neuroscience. 2011;1(12): 775-787. PMID: 21218131 | PMCID: PMC3016054
  • Borue X, Condron B, Venton B. Both synthesis and reuptake are critical for replenishing the releasable serotonin pool in Drosophila. Journal of neurochemistry. 2010;113(1): 188-99. PMID: 20070864 | PMCID: PMC2860618
  • Cechova S, Elsobky A, Venton B. A1 receptors self-regulate adenosine release in the striatum: evidence of autoreceptor characteristics. Neuroscience. 2010;171(4): 1006-15. PMID: 20933584 | PMCID: PMC2991493
  • Jacobs C, Peairs M, Venton B. Review: Carbon nanotube based electrochemical sensors for biomolecules. Analytica chimica acta. 2010;662(2): 105-27. PMID: 20171310
  • Kile B, Guillot T, Venton B, Wetsel W, Augustine G, Wightman R. Synapsins differentially control dopamine and serotonin release. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010;30(29): 9762-70. PMID: 20660258 | PMCID: PMC2923550
  • Xu Y, Venton B. Rapid determination of adenosine deaminase kinetics using fast-scan cyclic voltammetry. Physical chemistry chemical physics : PCCP. 2010;12(34): 10027-32. PMID: 20577678
  • Borue X, Cooper S, Hirsh J, Condron B, Venton B. Quantitative evaluation of serotonin release and clearance in Drosophila. Journal of neuroscience methods. 2009;179(2): 300-8. PMID: 19428541 | PMCID: PMC2691387
  • Cooper S, Venton B. Fast-scan cyclic voltammetry for the detection of tyramine and octopamine. Analytical and bioanalytical chemistry. 2009;394(1): 329-36. PMID: 19189084
  • Vickrey T, Condron B, Venton B. Detection of endogenous dopamine changes in Drosophila melanogaster using fast-scan cyclic voltammetry. Analytical chemistry. 2009;81(22): 9306-13. PMID: 19842636 | PMCID: PMC2876717
  • Cechova S, Venton B. Transient adenosine efflux in the rat caudate-putamen. Journal of neurochemistry. 2008;105(4): 1253-63. PMID: 18194431
  • Huffman M, Venton B. Carbon-fiber microelectrodes for in vivo applications. The Analyst. 2008;134(1): 18-24. PMID: 19082168 | PMCID: PMC2684111
  • Strand A, Venton B. Flame etching enhances the sensitivity of carbon-fiber microelectrodes. Analytical chemistry. 2008;80(10): 3708-15. PMID: 18416534
  • Swamy B, Venton B. Carbon nanotube-modified microelectrodes for simultaneous detection of dopamine and serotonin in vivo. The Analyst. 2007;132(9): 876-84. PMID: 17710262
  • Swamy B, Venton B. Subsecond detection of physiological adenosine concentrations using fast-scan cyclic voltammetry. Analytical chemistry. 2007;79(2): 744-50. PMID: 17222045
  • Venton B, Robinson T, Kennedy R, Maren S. Dynamic amino acid increases in the basolateral amygdala during acquisition and expression of conditioned fear. The European journal of neuroscience. 2006;23(12): 3391-8. PMID: 16820029
  • Venton B, Seipel A, Phillips P, Wetsel W, Gitler D, Greengard P, Augustine G, Wightman R. Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006;26(12): 3206-9. PMID: 16554471
  • Venton B, Wightman R. Pharmacologically induced, subsecond dopamine transients in the caudate-putamen of the anesthetized rat. Synapse (New York, N.Y.). 2006;61(1): 37-9. PMID: 17068772
  • Watson C, Venton B, Kennedy R. In vivo measurements of neurotransmitters by microdialysis sampling. Analytical chemistry. 2006;78(5): 1391-9. PMID: 16570388
  • Venton B, Robinson T, Kennedy R. Transient changes in nucleus accumbens amino acid concentrations correlate with individual responsivity to the predator fox odor 2,5-dihydro-2,4,5-trimethylthiazoline. Journal of neurochemistry. 2005;96(1): 236-46. PMID: 16300631
  • Garris P, Budygin E, Phillips P, Venton B, Robinson D, Bergstrom B, Rebec G, Wightman R. A role for presynaptic mechanisms in the actions of nomifensine and haloperidol. Neuroscience. 2003;118(3): 819-29. PMID: 12710989
  • Robinson D, Venton B, Heien M, Wightman R. Detecting subsecond dopamine release with fast-scan cyclic voltammetry in vivo. Clinical chemistry. 2003;49(10): 1763-73. PMID: 14500617
  • Venton B, Michael D, Wightman R. Correlation of local changes in extracellular oxygen and pH that accompany dopaminergic terminal activity in the rat caudate-putamen. Journal of neurochemistry. 2003;84(2): 373-81. PMID: 12558999
  • Venton B, Zhang H, Garris P, Phillips P, Sulzer D, Wightman R. Real-time decoding of dopamine concentration changes in the caudate-putamen during tonic and phasic firing. Journal of neurochemistry. 2003;87(5): 1284-95. PMID: 14622108
  • Troyer K, Heien M, Venton B, Wightman R. Neurochemistry and electroanalytical probes. Current opinion in chemical biology. 2002;6(5): 696-703. PMID: 12413556
  • Venton B, Troyer K, Wightman R. Response times of carbon fiber microelectrodes to dynamic changes in catecholamine concentration. Analytical chemistry. 2002;74(3): 539-46. PMID: 11838672