Andrew Dudley

Education

  • PhD, University of Melbourne
  • Postdoc, Boston Children's Hospital, Harvard Medical School

Primary Appointment

  • Associate Professor, Microbiology, Immunology, and Cancer Biology

Contact

Research Interest(s)

Tumor microenvironment and mechanisms of tumor neovascularization

Research Description

The Dudley laboratory is focused on the tumor microenvironment and mechanisms of tumor neovascularization. We use transgenic tumor models, in vivo lineage tracing strategies, and freshly isolated tumor-specific endothelial cells to explore differentiation and specialization of the tumor vasculature. We are also focused on how other cell types in the tumor microenvironment including adipocytes, fibroblasts, and inflammatory cells contribute to the growth and formation of new tumor blood vessels. Our goals are to i) understand how different types of cells in the tumor microenvironment coalesce to form new tumor vasculature ii) determine how abnormalities in the tumor vasculature contribute to tumor progression, responses to therapy, and metastasis iii) develop new tumor microenvironment-targeted therapies that are based on a systematic understanding of tumor vascular biology.

Selected Publications

  • Adapala R, Thoppil R, Ghosh K, Cappelli H, Dudley A, Paruchuri S, Keshamouni V, Klagsbrun M, Meszaros J, Chilian W, Ingber D, Thodeti C. Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy. Oncogene. 2015;35(3): 314-22. PMID: 25867067
  • Dudley A, Bautch V. Feeding cancer's sweet tooth: specialized tumour vasculature shuttles glucose in pancreatic ductal adenocarcinoma. The Journal of pathology. 2015;236(2): 133-5. PMID: 25727340 | PMCID: PMC4428916
  • Thoppil R, Adapala R, Cappelli H, Kondeti V, Dudley A, Gary Meszaros J, Paruchuri S, Thodeti C. TRPV4 channel activation selectively inhibits tumor endothelial cell proliferation. Scientific reports. 2015;5 14257. PMID: 26388427 | PMCID: PMC4585691
  • Xiao L, Kim D, Davis C, McCann J, Dunleavey J, Vanderlinden A, Xu N, Pattenden S, Frye S, Xu X, Onaitis M, Monaghan-Benson E, Burridge K, Dudley A. Tumor Endothelial Cells with Distinct Patterns of TGFβ-Driven Endothelial-to-Mesenchymal Transition. Cancer research. 2015;75(7): 1244-54. PMID: 25634211 | PMCID: PMC4383705
  • Xiao L, McCann J, Dudley A. Isolation and Culture Expansion of Tumor-specific Endothelial Cells. Journal of visualized experiments : JoVE. 2015; e53072. PMID: 26554446 | PMCID: PMC4692661
  • Dunleavey J, Dudley A. Vascular Mimicry: Concepts and Implications for Anti-Angiogenic Therapy. Current angiogenesis. 2014;1(2): 133-138. PMID: 24729954 | PMCID: PMC3982611
  • Dunleavey J, Xiao L, Thompson J, Kim M, Shields J, Shelton S, Irvin D, Brings V, Ollila D, Brekken R, Dayton P, Melero-Martin J, Dudley A. Vascular channels formed by subpopulations of PECAM1+ melanoma cells. Nature communications. 2014;5 5200. PMID: 25335460 | PMCID: PMC4261234
  • Kushner E, Ferro L, Liu J, Durrant J, Rogers S, Dudley A, Bautch V. Excess centrosomes disrupt endothelial cell migration via centrosome scattering. The Journal of cell biology. 2014;206(2): 257-72. PMID: 25049273 | PMCID: PMC4107782
  • Song G, Darr D, Santos C, Ross M, Valdivia A, Jordan J, Midkiff B, Cohen S, Nikolaishvili-Feinberg N, Miller C, Tarrant T, Rogers A, Dudley A, Perou C, Zamboni W. Effects of tumor microenvironment heterogeneity on nanoparticle disposition and efficacy in breast cancer tumor models. Clinical cancer research : an official journal of the American Association for Cancer Research. 2014;20(23): 6083-95. PMID: 25231403 | PMCID: PMC4565518
  • Harrell J, Pfefferle A, Zalles N, Prat A, Fan C, Khramtsov A, Olopade O, Troester M, Dudley A, Perou C. Endothelial-like properties of claudin-low breast cancer cells promote tumor vascular permeability and metastasis. Clinical & experimental metastasis. 2013;31(1): 33-45. PMID: 23975155 | PMCID: PMC3892109
  • Xiao L, Harrell J, Perou C, Dudley A. Identification of a stable molecular signature in mammary tumor endothelial cells that persists in vitro. Angiogenesis. 2013;17(3): 511-8. PMID: 24257808 | PMCID: PMC4029871
  • Tumor endothelial cells. Cold Spring Harbor perspectives in medicine. 2012;2(3): a006536. PMID: 22393533 | PMCID: PMC3282494