Amy H. Bouton


  • ScB, Brown University, Providence, RI
  • PhD, University of Virginia
  • Postdoc, University of Virginia

Primary Appointment

  • Professor, Microbiology, Immunology, and Cancer Biology


Research Interest(s) advil and viagra

Research Description

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Selected Publications

  • Gutknecht M, Bouton A. Functional significance of mononuclear phagocyte populations generated through adult hematopoiesis. Journal of leukocyte biology. 2014. PMID: 25225678 | PMCID: PMC4226790
  • Owen K, Meyer C, Bouton A, Casanova J. Activation of focal adhesion kinase by Salmonella suppresses autophagy via an Akt/mTOR signaling pathway and promotes bacterial survival in macrophages. PLoS pathogens. 2014;10(6): e1004159. PMID: 24901456 | PMCID: PMC4047085
  • Zhao Y, Kumbrink J, Lin B, Bouton A, Yang S, Toselli P, Kirsch K. Expression of a phosphorylated substrate domain of p130Cas promotes PyMT-induced c-Src-dependent murine breast cancer progression. Carcinogenesis. 2013;34(12): 2880-90. PMID: 23825155 | PMCID: PMC3845889
  • Ray B, Thomas K, Huang C, Gutknecht M, Botchwey E, Bouton A. Regulation of osteoclast structure and function by FAK family kinases. Journal of leukocyte biology. 2012. PMID: 22941736 | PMCID: PMC3476245
  • Owen K, Abshire M, Tilghman R, Casanova J, Bouton A. FAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing. PloS one. 2011;6(8): e23123. PMID: 21887232 | PMCID: PMC3160839
  • Stokes J, Adair S, Slack-Davis J, Walters D, Tilghman R, Hershey E, Lowrey B, Thomas K, Bouton A, Hwang R, Stelow E, Parsons J, Bauer T. Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment. Molecular cancer therapeutics. 2011;10(11): 2135-45. PMID: 21903606 | PMCID: PMC3213273
  • Abshire M, Thomas K, Owen K, Bouton A. Macrophage motility requires distinct α5β1/FAK and α4β1/paxillin signaling events. Journal of leukocyte biology. 2010;89(2): 251-7. PMID: 21084629 | PMCID: PMC3024900
  • Schuh N, Guerrero M, Schrecengost R, Bouton A. BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling. The Journal of biological chemistry. 2009;285(4): 2309-17. PMID: 19940159 | PMCID: PMC2807288
  • Ta H, Thomas K, Schrecengost R, Bouton A. A novel association between p130Cas and resistance to the chemotherapeutic drug adriamycin in human breast cancer cells. Cancer research. 2008;68(21): 8796-804. PMID: 18974122 | PMCID: PMC2597570
  • Owen K, Pixley F, Thomas K, Vicente-Manzanares M, Ray B, Horwitz A, Parsons J, Beggs H, Stanley E, Bouton A. Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase. The Journal of cell biology. 2007;179(6): 1275-87. PMID: 18070912 | PMCID: PMC2140030
  • Cowell L, Graham J, Bouton A, Clarke C, O'Neill G. Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway. Oncogene. 2006;25(58): 7597-607. PMID: 16799644
  • Riggins R, Thomas K, Ta H, Wen J, Davis R, Schuh N, Donelan S, Owen K, Gibson M, Shupnik M, Silva C, Parsons S, Clarke R, Bouton A. Physical and functional interactions between Cas and c-Src induce tamoxifen resistance of breast cancer cells through pathways involving epidermal growth factor receptor and signal transducer and activator of transcription 5b. Cancer research. 2006;66(14): 7007-15. PMID: 16849545