- Biomedical Sciences Graduate Program | Alexandra Kadl

Alexandra Kadl

Education

  • MD, Medical University of Vienna

Primary Appointment

  • Assistant Professor, Medicine- Pulmonary and Critical Care Medicine

Contact

Research Interest(s)

Lung injury and repair, sepsis

Research Description

Lung injury and repair, sepsis

Selected Publications

  • Juncadella I, Kadl A, Sharma A, Shim Y, Hochreiter-Hufford A, Borish L, Ravichandran K. Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation. Nature. 2012. PMID: 23235830 | PMCID: PMC3662023
  • Kadl A, Sharma P, Chen W, Agrawal R, Meher A, Rudraiah S, Grubbs N, Sharma R, Leitinger N. Oxidized phospholipid-induced inflammation is mediated by Toll-like receptor 2. Free radical biology & medicine. 2011;51(10): 1903-9. PMID: 21925592 | PMCID: PMC3197756
  • Kadl A, Meher A, Sharma P, Lee M, Doran A, Johnstone S, Elliott M, Gruber F, Han J, Chen W, Kensler T, Ravichandran K, Isakson B, Wamhoff B, Leitinger N. Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2. Circulation research. 2010;107(6): 737-46. PMID: 20651288 | PMCID: PMC2941538
  • Elliott M, Chekeni F, Trampont P, Lazarowski E, Kadl A, Walk S, Park D, Woodson R, Ostankovich M, Sharma P, Lysiak J, Harden T, Leitinger N, Ravichandran K. Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance. Nature. 2009;461(7261): 282-6. PMID: 19741708 | PMCID: PMC2851546
  • Kadl A, Galkina E, Leitinger N. Induction of CCR2-dependent macrophage accumulation by oxidized phospholipids in the air-pouch model of inflammation. Arthritis and rheumatism. 2009;60(5): 1362-71. PMID: 19404946 | PMCID: PMC2745196
  • Leonarduzzi G, Gamba P, Gargiulo S, Sottero B, Kadl A, Biasi F, Chiarpotto E, Leitinger N, Vendemiale G, Serviddio G, Poli G. Oxidation as a crucial reaction for cholesterol to induce tissue degeneration: CD36 overexpression in human promonocytic cells treated with a biologically relevant oxysterol mixture. Aging cell. 2008;7(3): 375-82. PMID: 18331615
  • von Schlieffen E, Oskolkova O, Schabbauer G, Gruber F, Blüml S, Genest M, Kadl A, Marsik C, Knapp S, Chow J, Leitinger N, Binder B, Bochkov V. Multi-hit inhibition of circulating and cell-associated components of the toll-like receptor 4 pathway by oxidized phospholipids. Arteriosclerosis, thrombosis, and vascular biology. 2008;29(3): 356-62. PMID: 19112167
  • Gruber F, Oskolkova O, Leitner A, Mildner M, Mlitz V, Lengauer B, Kadl A, Mrass P, Krönke G, Binder B, Bochkov V, Leitinger N, Tschachler E. Photooxidation generates biologically active phospholipids that induce heme oxygenase-1 in skin cells. The Journal of biological chemistry. 2007;282(23): 16934-41. PMID: 17449870
  • Kadl A, Pontiller J, Exner M, Leitinger N. Single bolus injection of bilirubin improves the clinical outcome in a mouse model of endotoxemia. Shock (Augusta, Ga.). 2007;28(5): 582-8. PMID: 17577133