Alev Erisir

Education

  • MD, Istanbul University
  • PhD, SUNY at Stony Brook
  • Postdoc, New York University
  • Postdoc, New York Medical College

Primary Appointment

  • Associate Professor, Psychology

Contact

Research Interest(s)

Developmental plasticity; Glutamate and acetylcholine receptors in visual cortex development

Research Description

We are interested in the development and plasticity of visual system. Our present research is concentrated on an early neonatal period in life, before the visual cortex attains its mature structure and function, that is, before lifelong connections among neurons are formed, and adult-type molecular signatures of different circuitries are established. During this period, the brain maintains a remarkable malleability to changes in the environment, such as lack of light, or lack of balanced stimulation through both eyes. By studying the molecules that are in function during this period, we aim to understand plasticity, that is what allows the brain to change, adapt, learn or resist to change in response to alterations in our environment. In particular, we are interested in the changing patterns of glutamate and GABA receptor localization in cells that receive monosynaptic input from developing thalamocortical cells, during, before and after the critical period for ocular dominance formation. We use the techniques, including tract-tracing and immunocytochemisty, to examine temporal sequence of neurotransmitter receptor localization at light and electron microscope resolutions.

Selected Publications

  • Corson J, Erisir A. Monosynaptic convergence of chorda tympani and glossopharyngeal afferents onto ascending relay neurons in the nucleus of the solitary tract: a high-resolution confocal and correlative electron microscopy approach. The Journal of comparative neurology. 2013;521(13): 2907-26. PMID: 23640852 | PMCID: PMC3953562
  • Holloway B, Stornetta R, Bochorishvili G, Erisir A, Viar K, Guyenet P. Monosynaptic glutamatergic activation of locus coeruleus and other lower brainstem noradrenergic neurons by the C1 cells in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013;33(48): 18792-805. PMID: 24285886 | PMCID: PMC3841449
  • Rose K, Lunardi N, Boscolo A, Dong X, Erisir A, Jevtovic-Todorovic V, Todorovic S. Immunohistological demonstration of CaV3.2 T-type voltage-gated calcium channel expression in soma of dorsal root ganglion neurons and peripheral axons of rat and mouse. Neuroscience. 2013;250 263-74. PMID: 23867767 | PMCID: PMC3796369
  • Sun C, Sun J, Erisir A, Kapur J. Loss of cholecystokinin-containing terminals in temporal lobe epilepsy. Neurobiology of disease. 2013;62 44-55. PMID: 24051276 | PMCID: PMC3877730
  • Wang S, Corson J, Hill D, Erisir A. Postnatal development of chorda tympani axons in the rat nucleus of the solitary tract. The Journal of comparative neurology. 2012;520(14): 3217-35. PMID: 22430892 | PMCID: PMC3418376
  • Corson J, Aldridge A, Wilmoth K, Erisir A. A survey of oral cavity afferents to the rat nucleus tractus solitarii. The Journal of comparative neurology. 2011;520(3): 495-527. PMID: 21800298 | PMCID: PMC3371193
  • Li J, Erisir A, Cline H. In vivo time-lapse imaging and serial section electron microscopy reveal developmental synaptic rearrangements. Neuron. 2011;69(2): 273-86. PMID: 21262466 | PMCID: PMC3052740
  • Coleman J, Nahmani M, Gavornik J, Haslinger R, Heynen A, Erisir A, Bear M. Rapid structural remodeling of thalamocortical synapses parallels experience-dependent functional plasticity in mouse primary visual cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010;30(29): 9670-82. PMID: 20660250 | PMCID: PMC3065324
  • Corson J, Nahmani M, Lubarsky K, Badr N, Wright C, Erisir A. Sensory activity differentially modulates N-methyl-D-aspartate receptor subunits 2A and 2B in cortical layers. Neuroscience. 2009;163(3): 920-32. PMID: 19596055 | PMCID: PMC2746878
  • Lunardi N, Ori C, Erisir A, Jevtovic-Todorovic V. General anesthesia causes long-lasting disturbances in the ultrastructural properties of developing synapses in young rats. Neurotoxicity research. 2009;17(2): 179-88. PMID: 19626389 | PMCID: PMC3629551
  • Corlew R, Wang Y, Ghermazien H, Erisir A, Philpot B. Developmental switch in the contribution of presynaptic and postsynaptic NMDA receptors to long-term depression. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007;27(37): 9835-45. PMID: 17855598 | PMCID: PMC2905826
  • May O, Erisir A, Hill D. Ultrastructure of primary afferent terminals and synapses in the rat nucleus of the solitary tract: comparison among the greater superficial petrosal, chorda tympani, and glossopharyngeal nerves. The Journal of comparative neurology. 2007;502(6): 1066-78. PMID: 17444498 | PMCID: PMC2798003