Alban Gaultier

Education

  • PhD, University of Pierre and Marie Curie

Primary Appointment

  • Assistant Professor, Neuroscience

Contact

Research Interest(s)

My research is focused on understanding the mechanisms involved in the initiation and progression of the neurodegenerative disease Multiple Sclerosis.

Research Description

The Gaultier lab focuses on understanding the mechanisms of disease initiation and progression to ultimately develop novel therapeutics to treat the debilitating symptoms of Multiple Sclerosis.

Selected Publications

  • Orita S, Henry K, Mantuano E, Yamauchi K, De Corato A, Ishikawa T, Feltri M, Wrabetz L, Gaultier A, Pollack M, Ellisman M, Takahashi K, Gonias S, Campana W. Schwann cell LRP1 regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013;33(13): 5590-602. PMID: 23536074 | PMCID: PMC3837698
  • Staudt N, Jo M, Hu J, Bristow J, Pizzo D, Gaultier A, VandenBerg S, Gonias S. Myeloid cell receptor LRP1/CD91 regulates monocyte recruitment and angiogenesis in tumors. Cancer research. 2013;73(13): 3902-12. PMID: 23633492 | PMCID: PMC3702673
  • Fernandez-Castaneda A, Arandjelovic S, Stiles T, Schlobach R, Mowen K, Gonias S, Gaultier A. Identification of the low density lipoprotein (LDL) receptor-related protein-1 interactome in central nervous system myelin suggests a role in the clearance of necrotic cell debris. The Journal of biological chemistry. 2012;288(7): 4538-48. PMID: 23264627 | PMCID: PMC3576060
  • Stiles T, Dickendesher T, Gaultier A, Fernandez-Castaneda A, Mantuano E, Giger R, Gonias S. LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin. Journal of cell science. 2012;126 209-20. PMID: 23132925 | PMCID: PMC3603516
  • Cousin H, Abbruzzese G, Kerdavid E, Gaultier A, Alfandari D. Translocation of the cytoplasmic domain of ADAM13 to the nucleus is essential for Calpain8-a expression and cranial neural crest cell migration. Developmental cell. 2011;20(2): 256-63. PMID: 21316592 | PMCID: PMC3074609
  • Gonias S, Gaultier A, Jo M. Regulation of the urokinase receptor (uPAR) by LDL receptor-related protein-1 (LRP1). Current pharmaceutical design. 2011;17(19): 1962-9. PMID: 21711236
  • Shi Y, Yamauchi T, Gaultier A, Takimoto S, Campana W, Gonias S. Regulation of cytokine expression by Schwann cells in response to α2-macroglobulin binding to LRP1. Journal of neuroscience research. 2011;89(4): 544-51. PMID: 21290408 | PMCID: PMC3560970
  • Gaultier A, Simon G, Niessen S, Dix M, Takimoto S, Cravatt B, Gonias S. LDL receptor-related protein 1 regulates the abundance of diverse cell-signaling proteins in the plasma membrane proteome. Journal of proteome research. 2010;9(12): 6689-95. PMID: 20919742 | PMCID: PMC2997161
  • Gorovoy M, Gaultier A, Campana W, Firestein G, Gonias S. Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages. Journal of leukocyte biology. 2010;88(4): 769-78. PMID: 20610799 | PMCID: PMC2974427
  • Gaultier A, Hollister M, Reynolds I, Hsieh E, Gonias S. LRP1 regulates remodeling of the extracellular matrix by fibroblasts. Matrix biology : journal of the International Society for Matrix Biology. 2009;29(1): 22-30. PMID: 19699300 | PMCID: PMC2818094
  • Gaultier A, Wu X, Le Moan N, Takimoto S, Mukandala G, Akassoglou K, Campana W, Gonias S. Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis. Journal of cell science. 2009;122 1155-62. PMID: 19299462 | PMCID: PMC2714439
  • Inoue G, Gaultier A, Li X, Mantuano E, Richardson G, Takahashi K, Campana W. Erythropoietin promotes Schwann cell migration and assembly of the provisional extracellular matrix by recruiting beta1 integrin to the cell surface. Glia. 2009;58(4): 399-409. PMID: 19705458 | PMCID: PMC2807473
  • Gaultier A, Arandjelovic S, Niessen S, Overton C, Linton M, Fazio S, Campana W, Cravatt B, Gonias S. Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor. Blood. 2008;111(11): 5316-25. PMID: 18369152 | PMCID: PMC2396725
  • Mantuano E, Inoue G, Li X, Takahashi K, Gaultier A, Gonias S, Campana W. The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of schwann cells by binding to low-density lipoprotein receptor-related protein. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008;28(45): 11571-82. PMID: 18987193 | PMCID: PMC3837707
  • Gaultier A, Arandjelovic S, Li X, Janes J, Dragojlovic N, Zhou G, Dolkas J, Myers R, Gonias S, Campana W. A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents. The Journal of clinical investigation. 2007;118(1): 161-72. PMID: 18060043 | PMCID: PMC2104478
  • Montel V, Gaultier A, Lester R, Campana W, Gonias S. The low-density lipoprotein receptor-related protein regulates cancer cell survival and metastasis development. Cancer research. 2007;67(20): 9817-24. PMID: 17942912
  • Campana W, Li X, Dragojlovic N, Janes J, Gaultier A, Gonias S. The low-density lipoprotein receptor-related protein is a pro-survival receptor in Schwann cells: possible implications in peripheral nerve injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006;26(43): 11197-207. PMID: 17065459
  • Gaultier A, Salicioni A, Arandjelovic S, Gonias S. Regulation of the composition of the extracellular matrix by low density lipoprotein receptor-related protein-1: activities based on regulation of mRNA expression. The Journal of biological chemistry. 2006;281(11): 7332-40. PMID: 16407289
  • Jo M, Thomas K, Takimoto S, Gaultier A, Hsieh E, Lester R, Gonias S. Urokinase receptor primes cells to proliferate in response to epidermal growth factor. Oncogene. 2006;26(18): 2585-94. PMID: 17043637
  • Alfandari D, Cousin H, Gaultier A, Hoffstrom B, DeSimone D. Integrin alpha5beta1 supports the migration of Xenopus cranial neural crest on fibronectin. Developmental biology. 2003;260(2): 449-64. PMID: 12921745
  • Moreau N, Alfandari D, Gaultier A, Cousin H, Darribère T. Cloning and expression patterns of dystroglycan during the early development of Xenopus laevis. Development genes and evolution. 2003;213(7): 355-9. PMID: 12739143
  • Salicioni A, Gaultier A, Brownlee C, Cheezum M, Gonias S. Low density lipoprotein receptor-related protein-1 promotes beta1 integrin maturation and transport to the cell surface. The Journal of biological chemistry. 2003;279(11): 10005-12. PMID: 14699139
  • Gaultier A, Cousin H, Darribère T, Alfandari D. ADAM13 disintegrin and cysteine-rich domains bind to the second heparin-binding domain of fibronectin. The Journal of biological chemistry. 2002;277(26): 23336-44. PMID: 11967265
  • Smith K, Gaultier A, Cousin H, Alfandari D, White J, DeSimone D. The cysteine-rich domain regulates ADAM protease function in vivo. The Journal of cell biology. 2002;159(5): 893-902. PMID: 12460986 | PMCID: PMC2173380
  • Alfandari D, Cousin H, Gaultier A, Smith K, White J, Darribère T, DeSimone D. Xenopus ADAM 13 is a metalloprotease required for cranial neural crest-cell migration. Current biology : CB. 2001;11(12): 918-30. PMID: 11448768
  • Cousin H, Gaultier A, Bleux C, Darribère T, Alfandari D. PACSIN2 is a regulator of the metalloprotease/disintegrin ADAM13. Developmental biology. 2000;227(1): 197-210. PMID: 11076687
  • Darribère T, Skalski M, Cousin H, Gaultier A, Montmory C, Alfandari D. Integrins: regulators of embryogenesis. Biology of the cell / under the auspices of the European Cell Biology Organization. 2000;92(1): 5-25. PMID: 10761694